Development of dual functional glycoconjugated photosensitive supra molecules for advanced photodynamic therapy and photodynamic diagnosis.
Project/Area Number |
25288028
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Inorganic chemistry
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Research Institution | Nara Institute of Science and Technology |
Principal Investigator |
YANO Shigenobu 奈良先端科学技術大学院大学, 物質創成科学研究科, 客員教授 (60011186)
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Co-Investigator(Kenkyū-buntansha) |
KATAOKA Hiromi 名古屋市立大学, 医学(系)研究科(研究院), 准教授 (40381785)
NARUMI Atsushi 山形大学, 理工学研究科, 准教授 (60443975)
NOMOTO Akihiro 大阪府立大学, 工学(系)研究科(研究院), 准教授 (60405347)
NAKAI Misaki 関西大学, 工学部, 准教授 (40527115)
AKASHI Haruo 岡山理科大学, 自然科学研究所, 教授 (30221708)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
|
Keywords | 光医療 / 光線力学療法 / 癌 / クロリン / フラーレン / 糖鎖 / 材料 |
Outline of Final Research Achievements |
Photodynamic therapy (PDT) has attracted much attention as a less invasive method for treating cancer. We have carried out in isolation and characterization of the third generation glycoconjugated chlorins and fullerenes for the advanced photodynamic therapy and photodynamic diagnosis (PDD) as described follows, 1) antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin, 2) a novel photodynamic therapy targeting cancer cells and tumor-associated macrophages, 3) efficient singlet oxygen generation from sugar pendant C60 derivatives for photodynamic therapy, 4) maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility etc.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility.2016
Author(s)
Atsushi Narumi, Takahiro Tsuji, Kosuke Shinohara, Hiromi Yamazaki, Moriya Kikuchi, Seigou Kawaguchi, Timoya Mae, Atsushi Ikeda, Yuichi Sakai, Hiromi Kataoka, Masahiro Inoue, Akihiro Nomoto, Jun-ichi Kikuchi, Shigenobu Yano.
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Journal Title
Org. Biomol. Chem
Volume: 14(14)
Issue: 14
Pages: 3608-13
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel photodynamic therapy targeting cancer cells and tumor-associated macrophages.2015
Author(s)
Hayashi N, Kataoka H, Yano S, Tanaka M, Moriwaki K, Akashi H, Suzuki S, Mori Y, Kubota E, Tanida S, Takahashi S, Joh T.
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Journal Title
Mol Cancer Ther.
Volume: 2
Issue: 4
Pages: 452-60
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin.2014
Author(s)
Tanaka M, Kataoka H, Yano S, Ohi H, Moriwaki K, Akashi H, Taguchi T, Hayashi N, Hamano S, Mori Y, Kubota E, Tanida S, Joh T.
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Journal Title
Mol Cancer Ther.
Volume: 4
Issue: 2
Pages: 767-75
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Glycoconjugated Rhenium(I) and 99m-Technetium(I) Carbonyl Complexes from Pyridyltriazole Ligands Obtained by “Click Chemistry”2014
Author(s)
Justyna A. Czaplewska, Frank Theil, Esra Altuntas, Tobias Niksch, Martin Freesmeyer, Bobby Happ, David Pretzel, Hendrik Schäfer, Makoto Obata, Shigenobu Yano, Ulrich S. Schubert, Michael Gottschaldt
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Journal Title
Eur. J. Inorg. Chem.
Volume: なし
Issue: 36
Pages: 6290-6297
DOI
Related Report
Peer Reviewed
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[Journal Article] Synthesis of miktoarm star copolymer Ru(II) complexes by click-to-chelate approach2013
Author(s)
Xiao, N., Chen, Y., Shen, X., Zhang, C., Yano, S. Gottschaldt, M., Schubert, U. S., Kakuchi, T., Satoh, T
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Journal Title
Polym. J
Volume: 45 (2)
Issue: 2
Pages: 216-225
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Syntheses, Structures, and Photochemical Properties of (µ3-O)Tris{bis(µ-carboxylato)} trimanganese Complexes with Naphthylacetate Ligands in Relevance to Artificial Solar Energy Harvesting System2013
Author(s)
M. Nakai, T. Funabiki., C. Ohtsuki, M. Harada, A. Ichimura, R. Tanaka, T. Nishioka, I. Kinoshita, M. Mikuriya, J. Guo, H. Benten, H. Ohkita, S. Ito, M. Obata, Y. Nakabayashi, S. Yano, Syntheses
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Journal Title
Inorg. Chim. Acta
Volume: 406
Pages: 130-137
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-cancer effects of newly developed chemotherapeutic agent, glycoconjugated palladium (II) complex, against cisplatin-resistant gastric cancer cells.2013
Author(s)
Tanaka M, Kataoka H, Yano S, Ohi H, Kawamoto K, Shibahara T, Mizoshita T, Mori Y, Tanida S, Kamiya T, Joh T.
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Journal Title
BMC Cancer
Volume: May 14;13:237
Issue: 1
Pages: 41-47
DOI
Related Report
Peer Reviewed
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