Reactivity and Selectivity of Hypochlorite Adducts of Metal Complexes
| Project/Area Number |
25288032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nara Women's University (2014-2016)
Okazaki Research Facilities, National Institutes of Natural Sciences (2013) |
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Principal Investigator |
Fujii Hiroshi 奈良女子大学, 自然科学系, 教授 (80228957)
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| Co-Investigator(Renkei-kenkyūsha) |
HADA Masahiko 首都大学東京, 理工学研究科, 教授 (20228480)
OGURA Takashi 兵庫県立大学, 生命理学研究科, 教授 (70183770)
ADACHI Shinichi 大学共同利用機関法人高エネルギー加速器機構, 物質構造科学研究所, 教授 (60260220)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | heme / salen / hypochlorite / chloroperoxidase / myeloperoxidase / chloride / oxidation / chlorination / 酵素反応 / 反応中間体 / 次亜塩素酸 / 不斉 / 反応性 / ヘム / 酸化反応 / 電子構造 |
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| Outline of Final Research Achievements |
In this project, we studied how hypochlorious acid is produced from the reaction of a high-valent oxoiron complex with chloride. This study points out that the key factor to produce hypochlorious acid is the reactivity of the high-valent oxoiron intermediate that is controlled by unique coordination structures of the active sites in the enzymes. In addition, we studied how the reactivity of the hypochlorite adduct complex is controlled. The most important factor to control the reactivity of the complex is electron donor ability form the cis- and trans-ligands. Interestingly, the electron donor effect of these two ligands show different trend to the reactivity.
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Report
(5 results)
Research Products
(53 results)
