Improved phodynamic activity by control of position of fullerene derivatives in liposomes
| Project/Area Number |
25288037
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional solid state chemistry
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| Research Institution | Hiroshima University (2014-2016)
Nara Institute of Science and Technology (2013) |
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Principal Investigator |
Ikeda Atsushi 広島大学, 工学(系)研究科(研究院), 教授 (90274505)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | フラーレン / リポソーム / ホスト-ゲスト錯体 / 光線力学治療 / シクロデキストリン / 光線力学活性 / 多糖 / マクロファージ / 光増感剤 / がん細胞 |
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| Outline of Final Research Achievements |
An effective exchange method is described whereby liposomal drug carriers of
hydrophobic fullerene are used to incorporate the guests into lipid membranes. The exchange method transfers the fullerenefrom a cyclodextrin cavity to a liposome in water. I attempted [60]Fullerene (C60) derivatives were incorporated into liposomes using a fullerene exchange method, but failed. However, in the experiments, we found that (i) C60 derivatives have much higher photodynamic activity thatn C60 under photoirradiation at long wavelengths (>610 nm) and (ii) beta-1,3-glucan-complexed an anionic C60 derivative has higher photoactivity toward RAW cells than other C60 derivatives. Recently, I succeeded the preparation of lipid-membrane-incorporated C60 derivatives.
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Report
(4 results)
Research Products
(63 results)
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[Journal Article] Maltotriose-conjugation to a fluorinated chlorin derivative generating a PDT photosensitizer with improved water-solubility.2016
Author(s)
Atsushi Narumi, Takahiro Tsuji, Kosuke Shinohara, Hiromi Yamazaki, Moriya Kikuchi, Seigou Kawaguchi, Timoya Mae, Atsushi Ikeda, Yuichi Sakai, Hiromi Kataoka, Masahiro Inoue, Akihiro Nomoto, Jun-ichi Kikuchi, Shigenobu Yano.
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Journal Title
Org. Biomol. Chem
Volume: 14(14)
Issue: 14
Pages: 3608-13
DOI
Related Report
Peer Reviewed
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[Journal Article] Porphyrin-uptake in liposomes and living cells using an exchange method with cyclodextrin2015
Author(s)
A. Ikeda, S. Hino, T. Mae, Y. Tsuchiya, K. Sugikawa, M. Tsukamoto, K. Yasuhara, H. Shigeto, H. Funabashi, A. Kuroda, M. Akiyama
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Journal Title
RSV Adv.
Volume: 5
Issue: 127
Pages: 105279-105287
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Liposome collapse resulting from an allosteric interaction between 2,6-dimethyl-β-cyclodextrins and lipids2015
Author(s)
Atsushi Ikeda, Noboru Iwata, Shodai Hino, Tomoya Mae, Yuki Tsuchiya, Kouta Sugikawa, Takehiro Hirao, Takeharu Haino, Kazuaki Ohara, Kentaro Yamaguchi
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Journal Title
RSC Advance
Volume: 5
Issue: 95
Pages: 77746-77754
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cyclodextrin Complexed [60]Fullerene Derivatives with High Levels of Photodynamic Activity by Long Wavelength Excitation.2013
Author(s)
Ikeda A, Iizuka T, Maekubo N, Aono R, Kikuchi J, Akiyama M, Konishi T, Ogawa T, Ishida-Kitagawa N, Tatebe H, Shiozaki K
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Journal Title
ACS Medicinal Chemistry Letters
Volume: 4
Issue: 8
Pages: 752-756
DOI
Related Report
Peer Reviewed
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