| Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2013: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
|
|---|
| Outline of Final Research Achievements |
An effective exchange method is described whereby liposomal drug carriers of
hydrophobic fullerene are used to incorporate the guests into lipid membranes. The exchange method transfers the fullerenefrom a cyclodextrin cavity to a liposome in water. I attempted [60]Fullerene (C60) derivatives were incorporated into liposomes using a fullerene exchange method, but failed. However, in the experiments, we found that (i) C60 derivatives have much higher photodynamic activity thatn C60 under photoirradiation at long wavelengths (>610 nm) and (ii) beta-1,3-glucan-complexed an anionic C60 derivative has higher photoactivity toward RAW cells than other C60 derivatives. Recently, I succeeded the preparation of lipid-membrane-incorporated C60 derivatives.
|
