| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
The key for the development of novel molecules inducing halogen bonding is the introduction electron-deficient fluorinated functional group into the structures. Therefore I first studied the development of new reagents for fluoro-functionalized reagents. After investigation, we developed novel trifluoromethylthiolation reagent, pentafluorophenylation reagent, and pentafluorosulfanylphenyl reagent. In addition, I succeeded the design and synthesis of fluoro-functionalized phthalocyanines and subphthalocyanines. Furthermore, corresponding fluoro-functionalized subphthalocyanine shows the remarkable ability for catalytic trifluoromethylation under LED red light. Finally, I investigated the halogen-binding possibility of various compounds thoroughly and I found the novel catalyst for Mukaiyama-aldol reaction based on the halogen bonding.
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