Preparation method of nanostructural materials made by biodegradable polymer

• Project/Area Number: 25288093
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Polymer/Textile materials
• Research Institution: Hokkaido University
• Principal Investigator: SATOH Toshifumi 北海道大学, 工学(系)研究科(研究院), 教授 (80291235)
• Co-Investigator(Kenkyū-buntansha): KAKUCHI Toyoji 北海道大学, 大学院工学研究院, 教授 (80113538) ; CHEN Yugen 北海道大学, 大学院工学研究院, 特任助教 (00731837) ; ISONO Takuya 北海道大学, 大学院工学研究院, 特任助教 (70740075)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
• Keywords: 生分解性高分子 / ナノ構造材料 / 精密合成 / ミクロ相分離

Outline of Final Research Achievements

Biodegradable porous film was fabricated using a rod-coil block copolymer consisting of poly(n-hexylisocyanate) (PHIC) and biodegradable polymers as a compatibilizing agent. At first, we prepared polymer alloy films composed of PHIC, biodegradable polymer, and compatibilizing agent. After annealed the film, the film was soaked into hexane to selectively remove PHIC from the film. The prepared film was observed by atomic force microscope (AFM) and confirmed to form pores. The average pore size was about 500 nm and cross sectional analysis showed that the pore persisted from the top surface to the substrate.　In addition, biodegradable film having microphase-separated structures with sub-20 nm periodicity was fabricated using block copolymers (BCPs) consisting of maltoheptaose and poly(ε-caprolactone) (PCL).

Research Products

• [Int'l Joint Research] 植物高分子研究所(フランス)
• [Int'l Joint Research] 国立台湾大学(台湾)
• [Int'l Joint Research] ポハン工科大学校(韓国)
• [Journal Article] Synthesis, morphology, and electrical memory application of oligosaccharide-based block copolymers with π-conjugated pyrene moieties and their supramolecules (2016)
  • Author(s): Han-Sheng Sun, Yougen Chen, Wen-Ya Lee, Yu-Cheng Chiu, Takuya Isono, Toshifumi Satoh, Toyoji Kakuchi and Wen-Chang Chen
  • Journal Title: Polymer Chemistry Volume: 7 Issue: 6 Pages: 1249-1263
  • DOI: 10.1039/c5py01697e
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sub-20 nm Microphase-Separated Structures in Hybrid Block Copolymers Consisting of Polycaprolactone and Maltoheptaose (2015)
  • Author(s): Takuya Isono, Issei Otsuka, Sami Halila, Redouane Borsali, Toyoji Kakuchi, Toshifumi Satoh
  • Journal Title: Journal of Photopolymer Science and Technology Volume: 28 Issue: 5 Pages: 635-642
  • DOI: 10.2494/photopolymer.28.635
  • NAID: 130005104276
  • ISSN: 0914-9244, 1349-6336
  • Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Complex Thin Film Morphologies of Poly(n-hexyl isocyanate)(5k,10k)－Poly(ε-caprolactone)1－3(10k,17k) Miktoarm Star Polymers (2015)
  • Author(s): Rarm Phinjaroenphan, Young Yong Kim, Brian J. Ree, Takuya Isono, Jinseok Lee, Supagorn Rugmai, Heesoo Kim, Santi Maensiri, Toyoji Kakuchi, Toshifumi Satoh, Moonhor Ree
  • Journal Title: Macromolecules Volume: 48 Issue: 16 Pages: 5816-5833
  • DOI: 10.1021/acs.macromol.5b00875
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Rod-Coil Type Miktoarm Star Copolymers Consisting of Polyfluorene and Polylactide: Precise Synthesis and Structure-Morphology Relationship (2015)
  • Author(s): Kengo Saito, Takuya Isono, Han-Sheng Sun, Toyoji Kakuchi, Wen-Chang Chen and Toshifumi Satoh
  • Journal Title: Polymer Chemistry Volume: 6 Issue: 39 Pages: 6959-6972
  • DOI: 10.1039/c5py01031d
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Sub-10 nm Scale Nanostructures in Self-Organized Linear Di- and Triblock Copolymers and Miktoarm Star Copolymers Consisting of Maltoheptaose and Polystyrene (2015)
  • Author(s): tsuka, I., Zhang, Y., Isono, T., Rochas, C., Kakuchi, T., Satoh, T., Borsali, R.
  • Journal Title: Macromolecules Volume: 48 Issue: 5 Pages: 1509-1517
  • DOI: 10.1021/ma502295y
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Grazing incidence small-angle X-ray scattering studies of the thin film morphologies of miktoarm crystalline star polymers (2014)
  • Author(s): Phinjaroenphan, R., Kim, Y. Y., Jung, S., Isono, T., Satoh, Y., Maensiri, S., Rugmai, S., Kakuchi, T., Satoh, T., Ree, M.
  • Journal Title: Sci. Adv. Mater. Volume: 6 Issue: 11 Pages: 2526-2531
  • DOI: 10.1166/sam.2014.2232
  • Peer Reviewed
• [Journal Article] Hierarchical Structures in Thin Films of Miktoarm Star Polymers: Poly(n-hexyl isocyanate)(12K)-Poly(ε-caprolactone)1-3(5K) (2014)
  • Author(s): Kim, Y. Y., Jung, S., Kim, C., Ree, B. J., Kawato, D., Nishikawa, N., Suemasa, D., Isono, T., Kakuchi, T., Satoh, T., Ree, M.
  • Journal Title: Macromolecules Volume: 47 Issue: 21 Pages: 7510-7524
  • DOI: 10.1021/ma501695b
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Precise synthesis of rod-coil type miktoarm star copolymer containing poly(n-hexyl isocyanate) and aliphatic polyester (2014)
  • Author(s): Satoh, T., Nishikawa, N., Kawato, D., Suemasa, D., Jung, S., Kim, Y-y., Ree, M., Kakuchi, T.
  • Journal Title: Polym. Chem. Volume: 5 Issue: 2 Pages: 588-599
  • DOI: 10.1039/c3py00985h
  • NAID: 120005530829
  • Peer Reviewed
• [Journal Article] Sub-10 nm Nano-organization in AB_2- and AB_3-Type Miktoarm Star Copolymers Consisting of Maltoheptaose and polycaprolactone (2013)
  • Author(s): 磯野拓也
  • Journal Title: Macromolecules Volume: 46 Issue: 4 Pages: 1461-1469
  • DOI: 10.1021/ma3026578
  • Peer Reviewed
• [Journal Article] Synthesis, Self-Assembly, and Thermal Charamelization of Maltoheptaose-Conjugated Polycaprolactones Leading to Spherical, Cylindrical, and Lamellar Morphologies (2013)
  • Author(s): 磯野 拓也、大塚 一世、末政 大地、Cyrill Rochas、佐藤 敏文、Redouane Borsali、覚知 豊次
  • Journal Title: Macromolecules Volume: 46 Issue: 22 Pages: 8932-8940
  • DOI: 10.1021/ma4019526
  • Peer Reviewed
• [Presentation] 糖鎖含有ブロック共重合体と糖類からなるブレンド薄膜の作製とナノ構造評価 (2016)
  • Author(s): 梅坪優人,磯野拓也、田島健次、佐藤敏文
  • Organizer: 2015年度高分子学会北海道支部研究発表会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2016-01-21
• [Presentation] オリゴ糖とポリカプロラクトンからなる星型ブロックコポリマーの精密合成 (2016)
  • Author(s): 川上菜穂、吉田康平、磯野拓也、田島健次、佐藤敏文
  • Organizer: 2015年度高分子学会北海道支部研究発表会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2016-01-21
• [Presentation] Synthesis of Architecturally Complex Block Copolymers Consisting of Oligosaccharides and Polyester via Organocatalytic Ring-Opening Polymerization (2015)
  • Author(s): Takuya Isono, Toshifumi Satoh
  • Organizer: Pacifichem 2015
  • Place of Presentation: ホノルル（米国）
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Sub-10 nm Scale Nano-Organization in AnBm-Type Miktoarm Star Copolymers Consisting of Polycaprolactone and Maltoheptaose (2015)
  • Author(s): Toshifumi Satoh
  • Organizer: Japan-Korea Joint Seminar 2015
  • Place of Presentation: 北九州国際会議場（北九州市）
  • Year and Date: 2015-10-28
  • Int'l Joint Research / Invited
• [Presentation] Sub-20 nm microphase-separated structures in hybrid block copolymers consisting of polycaprolactone and maltoheptaose (2015)
  • Author(s): Takuya Isono, Issei Otsuka, Sami Halila, Redouane Borsali, Toyoji Kakuchi, Toshifumi Satoh
  • Organizer: The 32nd International Conference of Photopolymer Science and Technology
  • Place of Presentation: 幕張メッセ（千葉市）
  • Year and Date: 2015-06-24
  • Int'l Joint Research / Invited
• [Presentation] Sub-10 nm Scale Nano-Organization in AnBm-Type Miktoarm Star Oligosaccharides based-Copolymers (2015)
  • Author(s): Toshifumi Satoh
  • Organizer: Japan-France Joint Seminar on Functional Block Copolymer 2015
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2015-05-31
  • Int'l Joint Research / Invited
• [Presentation] ポリフルオレンとポリ乳酸からなるブロック共重合体の合成とミクロ相分離構造 (2015)
  • Author(s): 齋藤憲吾・孫翰笙・磯野拓也・田島健次・陳文章・佐藤敏文
  • Organizer: 化学系学協会北海道支部2015年冬季研究発表会
  • Place of Presentation: 北海道大学、札幌
  • Year and Date: 2015-01-27 – 2015-01-28
• [Presentation] 光分解性ブロック共重合体を用いた生分解性ナノ構造体の創製 (2015)
  • Author(s): 齋藤 憲吾、孫 翰笙、磯野 拓也、田島 健次、陳 文章、佐藤 敏文
  • Organizer: 2014年度高分子学会北海道支部研究発表会
  • Place of Presentation: 北海道大学、札幌
  • Year and Date: 2015-01-26
• [Presentation] Synthesis and Self-Assembly of Hybrid Block Copolymers Consisting of Maltoheptaose and Polycaprolactone (2014)
  • Author(s): T. Isono, I. Otsuka, S. Halila, R. Borsali, T. Kakuchi, and T. Satoh
  • Organizer: 4th Franch Brazilian Meeting on Polymers
  • Place of Presentation: Florianopolis, Brazil
  • Year and Date: 2014-11-24 – 2014-11-28
  • Invited
• [Presentation] Synthesis and Morphological Characterization of Hybrid Block Copolymers Consisting of Maltoheptaose and Polycaprolactone (2014)
  • Author(s): Takuya Isono, Toyoji Kakuchi, Toshifumi Satoh
  • Organizer: Taiwan-Japan Bilateral Polymer Symposium 2014
  • Place of Presentation: National Cheng Kung University, Tainan, Taiwan
  • Year and Date: 2014-11-19 – 2014-11-22
  • Invited
• [Presentation] ポリフルオレンを基盤としたrod-coil型ブロック共重合体の合成と特性評価 (2014)
  • Author(s): 齋藤憲吾・磯野拓也・田島健次・佐藤敏文
  • Organizer: 第4回CSJ化学フェスタ2014
  • Place of Presentation: タワーホール船堀､東京
  • Year and Date: 2014-10-14 – 2014-10-16
• [Presentation] Synthesis and Nanoorganization of Miktoarm Star Polymers Consisting of Maltoheptaose and Polycaprolactone (2014)
  • Author(s): Takuya Isono, Issei Otsuka, Redouane Borsali, Toyoji Kakuchi, Toshifumi Satoh
  • Organizer: Korea-Japan Joint Polymer Symposium 2014
  • Place of Presentation: KAIST, Daejeon, Korea
  • Year and Date: 2014-09-29 – 2014-09-30
  • Invited
• [Presentation] 主鎖中央にアゾベンゼンを有するポリ乳酸の合成と光応答性 (2014)
  • Author(s): 笹森哲弥・磯野拓也・田島健次・佐藤敏文
  • Organizer: 2014年度北海道高分子若手研究会
  • Place of Presentation: 定山渓ビューホテル､札幌
  • Year and Date: 2014-08-29 – 2014-08-30
• [Presentation] Synthesis and Nanoparticle Formation of Triblock Copolymers Consisting of Oligosaccharide and Polystyrene (2014)
  • Author(s): Yao ZHANG, Takuya ISONO, Kenji TAJIMA, Toyoji KAKUCHI, Toshifumi SATOH
  • Organizer: 2014年度北海道高分子若手研究会
  • Place of Presentation: 定山渓ビューホテル､札幌
  • Year and Date: 2014-08-29 – 2014-08-30
• [Presentation] ポリn-ヘキシルイソシアナートと脂肪族ポリエステルからなる新規 rod-coil 型ミクトアームスターポリマーの精密合成 (2013)
  • Author(s): 西川直毅，末政大地，齋藤憲吾，覚知豊次，佐藤敏文
  • Organizer: 第62回高分子学会年次大会
  • Place of Presentation: 京都国際会館（京都市）
• [Presentation] Synthesis and Morphological Characterization of Miktoarm Star Polymers Consisting of Maltoheptaose and Polycaprolactone (2013)
  • Author(s): 磯野拓也、大塚一世、近藤洋平、佐藤敏文、Redouane Borsali、覚知豊次
  • Organizer: 第62回高分子学会年次大会
  • Place of Presentation: 京都国際会館（京都市）
• [Presentation] ポリイソシアネートとポリカプロラクトンからなる光分解性ブロック共重合体の精密合成
  • Author(s): 齋藤憲吾・末政大地・西川直毅・酒井直哉・田島健次・覚知豊次・佐藤敏文
  • Organizer: 日本化学会北海道支部2013年夏季研究発表会
  • Place of Presentation: 北見工業大学（北見市）
• [Presentation] Synthesis and Morphological Characterization of Miktoarm star Polymers Consisting of Maltoheptaose and Polycaprolactone
  • Author(s): Toshifumi Satoh
  • Organizer: 2013 SNU-HU Chemistry symposium on "The Present Chemistry at SNU and HU"
  • Place of Presentation: Seoul National University（ソウル市・韓国）
  • Invited