| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
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| Outline of Final Research Achievements |
The effects of hydration, especially hydrophobic hydration, on the phase behaviors of temperature-responsive polymers as a model system for the mechanism of protein foldings have been investigated from both experimental and theoretical points of view. We showed that the ν(C-D) bands of the polymers possessing deuterated alkyl groups at specific site exhibit red shifts on the phase separation and that the changes in hydrogen bonding to the ester and the alkyl groups are important to the shifts. We revealed the effects of copolymer and solvent compositions on five thermodynamic parameters such as ΔV and ΔS by analyzing temperature-pressure phase diagrams of various polymers. Tip-enhanced Raman spectrometers exhibiting special resolution beyond diffraction limit have also be prepared from atomic force microscopes and Raman spectrometers to investigate hydration of polymer chains in nano spaces.
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