| Co-Investigator(Kenkyū-buntansha) |
横山 昌幸 東京慈恵会医科大学, 医学部, 教授 (20220577)
白石 貢一 東京慈恵会医科大学, 医学部, 講師 (40426284)
藤井 秀司 大阪工業大学, 工学部, 准教授 (70434785)
岩崎 泰彦 関西大学, 工学部, 教授 (90280990)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
We have developed a method to dissolve hydrophobic fullerene (C60) which shows photothermal conversion effect in water. Thermo-responsive diblock copolymers which were prepared via a controlled radical polymerization method were used to dissolve C60 in water by complex formation of the diblock copolymer with C60. The C60 complex was consisted of C60-containing core and thermo-responsive shells. The size of the C60 complex increased due to inter-complexes aggregation with increasing temperature. In the future when the C60 complex is injected into the body, the complex may accumulate at tumor site by warming around the affected part. If light is irradiated to the affected part, the temperature of C60 increased to damage tumor site.
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