Application of thermo-sensitive complex containing photothermal conversion molecule, fullerene to cancer therapy
| Project/Area Number |
25288101
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Polymer/Textile materials
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| Research Institution | University of Hyogo |
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Principal Investigator |
Yusa Shin-ichi 兵庫県立大学, 工学(系)研究科(研究院), 准教授 (00301432)
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| Co-Investigator(Kenkyū-buntansha) |
横山 昌幸 東京慈恵会医科大学, 医学部, 教授 (20220577)
白石 貢一 東京慈恵会医科大学, 医学部, 講師 (40426284)
藤井 秀司 大阪工業大学, 工学部, 准教授 (70434785)
岩崎 泰彦 関西大学, 工学部, 教授 (90280990)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGO Shigeru 京都大学, 化学研究所, 教授 (30222368)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | 高分子 / 自己組織化 / ナノチューブ・フラーレン / 癌 / 高分子構造・物性 / 近赤外線 / ドラッグデリバリーシステム / 生体適合性高分子 / 高分子合成 / 近赤外光 |
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| Outline of Final Research Achievements |
We have developed a method to dissolve hydrophobic fullerene (C60) which shows photothermal conversion effect in water. Thermo-responsive diblock copolymers which were prepared via a controlled radical polymerization method were used to dissolve C60 in water by complex formation of the diblock copolymer with C60. The C60 complex was consisted of C60-containing core and thermo-responsive shells. The size of the C60 complex increased due to inter-complexes aggregation with increasing temperature. In the future when the C60 complex is injected into the body, the complex may accumulate at tumor site by warming around the affected part. If light is irradiated to the affected part, the temperature of C60 increased to damage tumor site.
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Report
(5 results)
Research Products
(321 results)
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[Journal Article] Heparin-binding copolymer reverses effects of unfractionated heparin, enoxaparin, and fondaparinux in rats and mice2016
Author(s)
Bartlomiej Kalaska, Kamil Kaminski, Joanna Miklosz, Shin-ichi Yusa, Emilia Sokolowska, Agnieszka Blazejczyk, Joanna Wietrzyk, Irena Kasacka, Krzysztof Szczubialka, Dariusz Pawlak, Maria Nowakowska, Andrzej Mogielnicki
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Journal Title
Translational Research
Volume: 177
Pages: 98-112.e10
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Polyphosphoester-based Paclitaxel Complexes: Biological Evaluation2016
Author(s)
K. Hirota, T. Hristova, V. Mitova, T. Koda, M. Fushimi, M. Kuniya, K. Makino, H. Terada, R. Cherkezova, S. Yusa, N. Koseva, K. Troev
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Journal Title
Anticancer Research
Volume: 4
Pages: 1613-1620
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Stable polymersomes based on ionic-zwitterionic block copolymers modified with superparamagnetic iron oxide nanoparticles for biomedical applications2015
Author(s)
G. Kania, U. Kwolek, K. Nakai, S. Yusa, J. Bednar, T. Wojcik, S. Chlopicki, T. Skorka, M. Szuwarzynski, K. Szczubialka, M. Kepczynski, M. Nowakowska
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Journal Title
Journal of Materials Chemistry B
Volume: 3
Issue: 27
Pages: 5523-5531
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Polyion complex aggregates2016
Author(s)
Shin-ichi Yusa
Organizer
Spetial Seminor organized by Jun Li,
Place of Presentation
National University of Singapore (Singapore)
Related Report
Int'l Joint Research / Invited
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[Presentation] Glycosaminoglycans as biomaterials, drugs, and pathogens2015
Author(s)
K. Kamiński, B. Kałaska, A. Mikulska, J. Filipowska, A. Osyczka,S. Yusa, M. Kajta, A. Mogielnicki, M. Nowakowska, and K. Szczubiałka
Organizer
27th European Conference on Biomaterials
Place of Presentation
Krakow (Poland)
Year and Date
2015-08-30
Related Report
Int'l Joint Research
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[Presentation] 溶性機能高分子の合成2015
Author(s)
遊佐真一
Organizer
第84回高分子若手研究会[関西]
Place of Presentation
神戸セミナーハウス（兵庫県神戸市）
Year and Date
2015-07-25
Related Report
Invited
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[Presentation] Surface Modification of Poly(dimethylsiloxane) by Biocompatible Photo-Cross-Linkable Amphiphilic Diblock Copolymer2014
Author(s)
K. Kuroda, S. Yusa, K. Ishihara, K. Morigaki, Y. Iwasaki, S. Fujii, T. Hirai, A. Takahara, H. Miyoshi, M. Maeki, M. Miyazaki
Organizer
5th Word Congress on Adhesion and Related Phenomena
Place of Presentation
Nara (Japan)
Year and Date
2014-09-07
Related Report
Int'l Joint Research
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[Presentation] Polyion Complex Micelles with Phosphobetaine Shells2014
Author(s)
S. Yusa, K. Nakai, M. Nishiuchi, M. Inoue, K. Ishihara, Y. Sanada, K. Sakurai
Organizer
1st International Society for Biomedical Polymers and Polymeric Biomaterials (ISBPPB)
Place of Presentation
Dulles (USA)
Year and Date
2014-07-09
Related Report
Int'l Joint Research / Invited
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[Presentation] Stimuli-responsive liquid marbles2013
Author(s)
S. Yusa, K. Nakai, S. Fujii, Y. Nakamura, Y. Iwasaki
Organizer
5th Asian Conference on Colloid and Interface Science (ACCIS 2013)
Place of Presentation
University of North Bengal (India)
Related Report
Invited
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