| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
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| Outline of Final Research Achievements |
We aim at achieving an artificial synapse that mimics the neuronal transmission mechanism, where semiconductor microwells are sealed with artificial cell membranes including membrane proteins. Versatile handling techniques for artificial cell membranes were established based on self-spreading of lipids and single giant vesicle manipulation. We found that the confinement of hydrogel in the microwells creates an environment similar to the living cell. We developed a new method utilizing the electrostatic interaction between the artificial cell membrane and the substrate when sealing the microwells with artificial cell membranes. We proposed a sophisticated device structure toward low noise and highly sensitive biosensors, and confirmed the operating principle of the device using model channel proteins. Our nanobiodevice will be a promising platform for analyzing and utilizing neurons.
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