Experimental verification for regulation of production of inflammatory cytokine by surface texturing on load bearing in artificial joint

• Project/Area Number: 25289024
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Design engineering/Machine functional elements/Tribology
• Research Institution: Kumamoto University
• Principal Investigator: Nakanishi Yoshitaka 熊本大学, 先端科学研究部(工), 教授 (90304740)
• Co-Investigator(Kenkyū-buntansha): 三浦 裕正 愛媛大学, 医学(系)研究科(研究院), 教授 (10239189) ; 村瀬 晃平 名古屋大学, 工学(系)研究科(研究院), 准教授 (80298934)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
• Keywords: 人工関節 / 炎症性サイトカイン / 表面テクスチャリング / 摩耗粉毒性 / 摩耗粉分析 / 超精密加工 / トライボロジー / 精密部品加工 / 生体工学 / 生体材料 / 摩耗粉解析 / 細胞毒性 / 貪食作用 / 摩耗 / ポリエチレン / 機械工学 / 設計工学 / 生体反応 / 耐食性金属

Outline of Final Research Achievements

In a polymer-on-hard artificial joint, the bearing parts are typically composed of an ultra-high molecular weight polyethylene and an alloy with good corrosion resistance, or polyethylene and a ceramic. Wear debris generated from the polyethylene part is considered a major factor in long-term osteolysis and loosening of artificial joints, because the presence of this debris stimulates macrophage activity, thereby promoting the production of cytokines. To control the specific wear rate and morphological features of wear debris of the polyethylene, micro slurry-jet erosion was used as a precision machining method for the bearing surface of a Co-Cr-Mo alloy. Pin-on-disc wear tests resulted in a decrease in the polyethylene wear and changes in the morphological features. Primary human peripheral blood mononuclear phagocytes were incubated with the debris, and the wear debris generated on the textured surface reduced the secretion of the IL-6 proinflammatory cytokines.

Research Products

• [Int'l Joint Research] James Cook University(オーストラリア)
• [Int'l Joint Research] University of Twente(オランダ)
• [Int'l Joint Research] Shanghai Advanced Research Institute(中国)
• [Int'l Joint Research] University of Twente(オランダ)
• [Journal Article] Method for measuring Young’s modulus of cells using a cell compression microdevice (2017)
  • Author(s): Tairo Yokokura, Yuta Nakashima, Yukihiro Yonemoto, Yuki Hikichi, Yoshitaka Nakanishi
  • Journal Title: International journal of Engineering Science Volume: 114 Pages: 41-48
  • DOI: 10.1016/j.ijengsci.2017.02.002
  • Peer Reviewed
• [Journal Article] In vivo kinematic analysis of the glenohumeral joint during dynamic full axial rotation and scapular plane full abduction in healthy shoulders (2016)
  • Author(s): Naoya Kozono, Takamitsu Okada, Naohide Takeuchi, Satoshi Hamai, Hidehiko Higaki, Satoru Ikebe, Takeshi Shimoto, Go Miake, Yoshitaka Nakanishi, Yukihide Iwamoto
  • Journal Title: Knee Surgery, Sports Traumatology, Arthroscopy Volume: - Issue: 7 Pages: 1-9
  • DOI: 10.1007/s00167-016-4263-2
  • Peer Reviewed
• [Journal Article] The biological response of macrophages to PMMA particles with different morphology and size (2016)
  • Author(s): R.Yoshioka, Y.Nakashima, Y.Fujiwara, Y.Komohara, M.Takeya, Y.Nakanishi
  • Journal Title: Biosurface and Biotriology Volume: 2 Issue: 3 Pages: 114-120
  • DOI: 10.1016/j.bsbt.2016.09.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Creation of cell micropatterns using a newly developed gel micromachining technique (2016)
  • Author(s): Yuta Nakashima, Yusuke Yamamoto, Yuki Hikichi, Yoshitaka Nakanishi
  • Journal Title: Biofabrication Volume: 8 Issue: 3 Pages: 1-10
  • DOI: 10.1088/1758-5090/8/3/035006
  • Peer Reviewed
• [Journal Article] Effect of micro slurry-jet erosion on the tribological behaviour of polymer material of artificial joint (2016)
  • Author(s): Y. Nakanishi, Y. Nakashima, Y. Fujiwara, Y. Komohara, M. Takeya, H. Miura, H. Higaki
  • Journal Title: Proceedings of the 17th Nordic Symposium on Tribology (NordTrib 2016) Volume: -
  • Acknowledgement Compliant
• [Journal Article] Effect of particle size on biological response by human monocyte-derived macrophages (2016)
  • Author(s): Hiroto CHIKAURA，Yuta NAKASHIMA，Yukio FUJIWARA，Yoshihiro KOMOHARA，Motohiro TAKEYA，Yoshitaka NAKANISHI
  • Journal Title: Biosurface and Biotribology Volume: 2(1) Issue: 1 Pages: 18-25
  • DOI: 10.1016/j.bsbt.2016.02.003
  • NAID: 120007145888
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Co-Cr-Mo合金への表面テクスチャリングが超高分子量ポリエチレンの摩耗粉に与える影響 (2015)
  • Author(s): 西真生，中島雄太，三浦裕正，日垣秀彦，水田博志，岩本幸英，中西義孝
  • Journal Title: 臨床バイオメカニクス Volume: 36 Pages: 189-195
  • NAID: 40020634348
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 人工股関節全置換術前後における深屈曲位からの立ち上がり動作時の動態解析 (2015)
  • Author(s): 池部怜, 王亦峰, 日垣秀彦, 石川篤, 白石善孝, 下戸腱 ,中西義孝, 原大介, 濱井敏, 中島康晴, 岩本幸英
  • Journal Title: 臨床バイオメカニクス Volume: 36 Pages: 253-258
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Textured bearing surface in artificial joints to reduce macrophage activation (2015)
  • Author(s): Nakanishi.Y，Nishi.N，Chikaura.H，Nakashima.Y，Miura.H，Higaki.H，Mizuta.H，Iwamoto.Y，Fujiwara.Y，Komohara.Y，Takeya.M
  • Journal Title: Surface Topography: Metrology and Properties Volume: 3(4) Pages: 1-10
  • NAID: 120007145889
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Shaft seal for separation of water and air with low frictional torque (2015)
  • Author(s): Y.Nakanishi，T.Honda，Y.Nakashima，H.Higaki
  • Journal Title: Tribology International Volume: 94 Pages: 437-445
  • DOI: 10.1016/j.triboint.2015.10.007
  • Peer Reviewed
• [Journal Article] Textured surface of Co-Cr-Mo alloy affects wear characteristics of ultra-high molecular weight polyethylene in total joint replacement (2015)
  • Author(s): Naoki NISHI, Hiroto CHIKAURA, Haruyuki MASAOKA, Riku YOSHIOKA, Yuta NAKASHIMA, Yukio FUJIWARA,Yoshihiro KOMOHARA, Motohiro TAKEYA, Hiroshi MIZUTA, Yoshitaka NAKANISHI
  • Journal Title: Proceedings of Japan-the Netherlands Symposium on Soft-Tribology Volume: 1 Pages: 85-88
  • Acknowledgement Compliant
• [Journal Article] The size of wear debris in total joint replacement affects cytokine release from macrophages (2015)
  • Author(s): Hiroto CHIKAURA, Naoki NISHI, Riku YOSHIKA, Haruyuki MASAOKA, Yuta NAKASHIMA, Yukio FUJIWARA, Yoshihiro KOMOHARA, Motohiro TAKEYA, Hiroshi MIZUTA, Yoshitaka NAKANISHI
  • Journal Title: Proceedings of Japan-the Netherlands Symposium on Soft-Tribology Volume: 1 Pages: 55-58
  • Acknowledgement Compliant
• [Journal Article] Micro Slurry-Jet Erosion as for Precision Processing to Bearing Surfaces (2015)
  • Author(s): Haruyuki MASAOKA, Riku YOSHIOKA, Naoki NISHI, Hiroto CHIKAURA, Toru MATUBARA, Yuta NAKASHIMA, Yoshitaka NAKANISHI
  • Journal Title: Proceedings of Japan-the Netherlands Symposium on Soft-Tribology Volume: 1 Pages: 63-66
  • Acknowledgement Compliant
• [Journal Article] Automatic droplet transportation on a plastic microfluidic device having wettability gradient surface (2015)
  • Author(s): Yuta Nakashima, Yoshitaka Nakanishi, Takashi Yasuda
  • Journal Title: Review of Scientific Instruments Volume: 86(1) Issue: 1
  • DOI: 10.1063/1.4905530
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Development of a cell culture surface conversion technique using alginate thin film for evaluating effect upon cellular differentiation (2014)
  • Author(s): Y. Nakashima, K. Tsusu, K. Minami, Y. Nakanishi
  • Journal Title: Review of Scientific Instruments Volume: 85(6) Issue: 6
  • DOI: 10.1063/1.4884076
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 人工膝関節全置換術前後におけるスクワット動作時の動態解析 (2014)
  • Author(s): 池部怜、日垣秀彦、石川篤、下戸健、中西義孝、西松和穂、白石善孝、石丸雅巳、三浦裕正
  • Journal Title: 臨床バイオメカニクス Volume: 35 Pages: 155-162
  • Peer Reviewed
• [Journal Article] Biomimetic Sealing System with Hydrated Materials for Ocean Current or Tidal Power Generation (2014)
  • Author(s): Yoshitaka NAKANISHI, Yuichi OKA, Jason Sanderson, Takuro HONDA, Keiji KASAMURA, Yuta NAKASHIMA, Hidehiko HIGAKI
  • Journal Title: Renewable Energy Research and Applications Volume: - Pages: 755-759
  • DOI: 10.1109/icrera.2014.7016486
  • Peer Reviewed
• [Journal Article] Development of A New Type Of Seal System For Use In Ocean Current Or Tidal Power Generation (2014)
  • Author(s): H.Cikaura, Y.Oka, Y.Nakashima, Y.Nakanishi
  • Journal Title: Power Electronics and Motion Control Conference and Exposition (PEMC) Volume: - Pages: 828-832
  • DOI: 10.1109/epepemc.2014.6980600
  • Peer Reviewed
• [Journal Article] Friction Control Of Biomimetic Bearings By Electric Field (2014)
  • Author(s): Y. Nakanishi, J. Sanderson, Y.Nakashima
  • Journal Title: Power Electronics and Motion Control Conference and Exposition (PEMC) Volume: - Pages: 751-761
  • DOI: 10.1109/epepemc.2014.6980588
  • Peer Reviewed
• [Journal Article] Monitoring of Cellular Behavior to Receive Mechanical Stimulation Controlled by Microdevice (2014)
  • Author(s): Y. Nakashima, Y. Nakanishi, Y. Yang, R. Monji, K. Minami and K. Sato
  • Journal Title: Power Electronics and Motion Control Conference and Exposition (PEMC) Volume: - Pages: 642-647
  • DOI: 10.1109/epepemc.2014.6980568
  • Peer Reviewed
• [Journal Article] Fabrication of a Microwell Array Having Convertible Cell Culture Surface and Observation of Cellular Behavior (2014)
  • Author(s): Y. Hikichi, Y. Nakashima, Y. Nakanishi, K. Tsusu and K. Minami
  • Journal Title: Power Electronics and Motion Control Conference and Exposition (PEMC) Volume: - Pages: 883-888
  • DOI: 10.1109/epepemc.2014.6980610
  • Peer Reviewed
• [Journal Article] Effect of Postoperative Passive Motion on Rotator Cuff Reconstruction With Acellular Dermal Matrix Grafts in a Rat Model (2014)
  • Author(s): Keiji Uezono, Junji Ide, Takuya Tokunaga, Hitoshi Arimura, Hidetoshi Sakamoto, Yoshitaka Nakanishi and Hiroshi Mizuta
  • Journal Title: The American Journal of Sports Medicine Volume: 42(8) Issue: 8 Pages: 1930-1938
  • DOI: 10.1177/0363546514532338
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 生体関節潤滑システムを模倣した防水システムによる河川流発電 (2014)
  • Author(s): 中西義孝, 嶋津賢了，岡祐一，峰誠司，松本保朗
  • Journal Title: バイオメカニズム22 Volume: 22 Pages: 259-267
  • NAID: 130005395171
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 人工関節の表面研磨法が摩耗粉とサイトカイン産生に与える影響 (2013)
  • Author(s): 中西義孝，日垣秀彦，三浦裕正，水田博志，岩本幸英
  • Journal Title: 臨床バイオメカニクス Volume: 34 Pages: 11-18
  • Peer Reviewed
• [Journal Article] 6自由度動態解析手法を用いた躓き動作時における健常膝骨の機能評価 (2013)
  • Author(s): 白石善孝、石丸雅巳、三浦裕正、日垣秀彦、石川篤、池部怜、西松和穂、中西義孝、田代泰隆、岩本幸秀
  • Journal Title: 臨床バイオメカニクス Volume: 34 Pages: 225-232
  • Peer Reviewed
• [Journal Article] 髄内釘の開発における力学試験とFEM解析の比較 (2013)
  • Author(s): 松本保朗、村山伸樹、日垣秀彦、岩本幸英、水田博志、中西義孝
  • Journal Title: 臨床バイオメカニクス Volume: 34 Pages: 93-99
  • Peer Reviewed
• [Journal Article] Finite Element Analysis of Titanium-Reinforced Polyetheretherketone Fracture Plating in Long Bones (2013)
  • Author(s): Jason SANDERSON, Nobuki MURAYAMA, Yoshitaka NAKANISHI
  • Journal Title: Journal of Biomechanical Science and Engineering Volume: 8(4) Pages: 225-232
  • NAID: 130003384006
  • Peer Reviewed
• [Journal Article] 整形インプラントの開発と非破壊的性能評価 (2013)
  • Author(s): 中西義孝
  • Journal Title: 非破壊検査 Volume: 62(10) Pages: 493-498
  • NAID: 10031202781
• [Presentation] 超精密微細加工による材料表面特性の調整 (2017)
  • Author(s): 中西義孝、森山俊樹、馬場貴司、中島雄太
  • Organizer: 日本機械学会九州支部
  • Place of Presentation: 佐賀大学理工学部（佐賀）
• [Presentation] Bio-inspired surface作成法に関する研究 (2017)
  • Author(s): 中西義孝、森山俊樹、馬場貴司、中島雄太
  • Organizer: 日本生体医工学会九州支部学術講演会
  • Place of Presentation: 九州大学（伊都キャンパス）
• [Presentation] Micro Wet Blasting による材料表面特性の改善 (2017)
  • Author(s): 馬場貴司、本田拓朗、中島雄太、日垣秀彦、中西義孝
  • Organizer: 第29回バイオエンジニアリング講演会
  • Place of Presentation: ウインク愛知（名古屋）
• [Presentation] Effect of precision machining for bearing surface in artificial joint on regulation of macrophage activation (2016)
  • Author(s): Y.Nakanishi, Y.Nakashima, S.Sakuraba, R.Yoshioka, Y.Fujiwara, Y.Komohara, M.Takeya, H.Miura, H.Higaki
  • Organizer: The 16th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore
  • Year and Date: 2016-12-07
  • Int'l Joint Research
• [Presentation] The Influence of Particle Morphology on Biological Response of Macrophages (2016)
  • Author(s): R. Yoshioka, Y. Nakashima, Y. Fujiwara, Y. Komohara, M. Takeya, Y. Nakanishi
  • Organizer: The 16th International Conference on Biomedical Engineering
  • Place of Presentation: Singapore
  • Year and Date: 2016-12-07
  • Int'l Joint Research
• [Presentation] 人工関節表面に最適な表面形状の検討 (2016)
  • Author(s): 森山 俊樹, 桜庭 新, 吉岡 陸, 中島 雄太, 中西 義孝
  • Organizer: 第27回バイオフロンティア講演会
  • Place of Presentation: 北海道（北海道大学）
  • Year and Date: 2016-10-22
• [Presentation] Effect of micro slurry-jet erosion on the tribological behaviour of polymer material of artificial joint (2016)
  • Author(s): Y. Nakanishi, Y. Nakashima, Y. Fujiwara, Y. Komohara, M. Takeya, H. Miura, H. Higaki
  • Organizer: The 17th Nordic Symposium on Tribology
  • Place of Presentation: Hameenlinna, Finland
  • Year and Date: 2016-06-14
  • Int'l Joint Research
• [Presentation] バイオマテリアルの表面特性が細胞接着性に及ぼす影響の実験的評価 (2016)
  • Author(s): 横倉泰郎，中島雄太，米本幸弘，引地勇気，中西義孝
  • Organizer: 日本機械学会九州支部第69期総会・講演会
  • Place of Presentation: 熊本大学（熊本市）
  • Year and Date: 2016-03-15
• [Presentation] 人工関節軸受面への表面テクスチャリングが超高分子量ポリエチレンの摩耗に与える影響 (2016)
  • Author(s): 西真生，近浦裕斗，吉岡陸，桜庭新，中島雄太，中西義孝
  • Organizer: 日本機械学会九州支部第69期総会・講演会
  • Place of Presentation: 熊本大学（熊本市）
  • Year and Date: 2016-03-15
• [Presentation] 微小粒子がヒト単球由来マクロファージの活性に与える影響 (2016)
  • Author(s): 近浦裕斗、西真生、吉岡陸、桜庭新、中島雄太、中西義孝
  • Organizer: 日本機械学会九州支部第69期総会・講演会
  • Place of Presentation: 熊本大学（熊本市）
  • Year and Date: 2016-03-15
• [Presentation] 人工関節摺動面のテクスチャリング方法とポリエチレンの摩耗特性への影響 (2016)
  • Author(s): 中西 義孝，中島 雄太，藤原 章雄，菰原 義弘，竹屋 元裕，水田博志，日垣秀彦
  • Organizer: 日本生体医工学会九州支部
  • Place of Presentation: 佐賀大学（佐賀市）
  • Year and Date: 2016-03-05
• [Presentation] ソフトマテリアル相手材に対する表面テクスチャの影響 (2016)
  • Author(s): 中西義孝，政岡晴行，中島雄太，日垣秀彦
  • Organizer: 日本機械学会第28回バイオエンジニアリング講演会
  • Place of Presentation: 東京工業大学（東京都）
  • Year and Date: 2016-01-09
• [Presentation] 人工関節摺動面から生じる超高分子ポリエチレン摩耗粉の形態および生体反応に関する研究 (2016)
  • Author(s): 吉岡陸，政岡晴行，近浦裕斗，西真生，中島雄太，藤原章雄，菰原義弘，竹屋元裕，水田博志，日垣秀彦，中西義孝
  • Organizer: 日本機械学会第28回バイオエンジニアリング講演会
  • Place of Presentation: 東京工業大学（東京都）
  • Year and Date: 2016-01-09
• [Presentation] 表面テクスチャリングが材料表面の親・疎水性に与える影響 (2016)
  • Author(s): 中西義孝, 中島雄太, 日垣秀彦, Chee Kent Yong, Xiangqiong Zeng, Enile van der Heide
  • Organizer: 日本機械学会 2016年度年次大会
  • Place of Presentation: 九州大学伊都キャンパス
• [Presentation] 人工関節における表面テクスチャリングの効果 (2016)
  • Author(s): 中西義孝, 中島雄太, 桜庭 新, 吉岡 陸, 日垣秀彦
  • Organizer: 日本機械学会 2016年度年次大会
  • Place of Presentation: 九州大学伊都キャンパス
• [Presentation] Precision machining to bearing surface for artificial joint inhibits macrophage actitation (2015)
  • Author(s): Nakanishi Yoshitaka, N.Nishi, H.Chikaura, Y.Nakashima, Y.Fujiwara, Y.Komohara, M.Taleya, H.Mizuta, H.Miura, H.Higaki
  • Organizer: 6th International Conference on Mechanics of Biomaterials and Tissues
  • Place of Presentation: Waikoloa, Hawaii, USA
  • Year and Date: 2015-12-06
  • Int'l Joint Research
• [Presentation] 人工関節の摩耗粉サイズとマクロファージのサイトカイン産生量の 関係に関する実験的考察 (2015)
  • Author(s): 近浦 裕斗、吉岡 陸、西 真生、中島 雄太、藤原 章雄、菰原 義弘、 三浦 裕正、岩本 幸英 、竹屋 元裕、水田 博志、日垣 秀彦、中西 義孝
  • Organizer: 第42回日本臨床バイオメカニクス学会
  • Place of Presentation: ソラシティカンファレンスセンター（東京都）
  • Year and Date: 2015-11-13
• [Presentation] MSE(Micro Slurry-jet Erosion)によるテクスチャリングが人工関節摺動面の摩耗に与える影響 (2015)
  • Author(s): 政岡晴行,吉岡陸,西真生,近浦裕斗,中島雄太,中西義孝
  • Organizer: 第26回バイオフロンティア講演会
  • Place of Presentation: 九州大学（福岡市）
  • Year and Date: 2015-10-02
• [Presentation] 人工関節からの摩耗粉がマクロファージの活動と炎症性サイトカイン産生量に与える影響 (2015)
  • Author(s): 近浦裕斗,西真生,吉岡陸,政岡晴行, 中島雄太,藤原章雄,菰原義弘,竹屋元裕, 水田博志,日垣秀彦,中西義孝
  • Organizer: 第26回バイオフロンティア講演会
  • Place of Presentation: 九州大学（福岡市）
  • Year and Date: 2015-10-02
• [Presentation] Effect of Particle Size on Biological Response by Human Monocyte-Derived Macrophages (2015)
  • Author(s): Y.Nakanishi, H.Chikaura, Y.Nakashima, Y.Fujiwara, Y.Komohara, M.Takeya
  • Organizer: The 8th International Biotribology Forum and The 36th Biotribology Symposium
  • Place of Presentation: Yokohama Symposia（横浜市）
  • Year and Date: 2015-09-23
  • Int'l Joint Research
• [Presentation] Textured Surface Processed by Micro Slurry-jet Erosion Reduces Wear of Polyethylene and Regulates Macrophage Activation (2015)
  • Author(s): Yoshitaka Nakanishi, Yuta Nakashima, Naoto Nishi, Hiroto Chikaura, Yukiko Fujiwara, Motohiro Takeya, Hiroshi Mizuta, Hiromasa Miura, Yukihide Iwamoto and Hidehiko Higaki
  • Organizer: International Tribology Conference, Tokyo 2015
  • Place of Presentation: Tokyo University of Science（東京都）
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] 人工関節軸受部の表面テクスチャが生体反応因子に与える影響 (2015)
  • Author(s): 中西義孝, 西真生, 近浦裕斗, 中島雄太, 藤原章雄, 菰原義弘, 竹 屋元裕, 水田博志, 三浦博正, 岩本幸秀, 日垣秀彦
  • Organizer: 日本機械学会2015年度年次大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2015-09-13
• [Presentation] 人工関節摺動面から発生する磨耗粉がマクロフ ァージの免疫機能に与える影響 (2015)
  • Author(s): 中島雄太, 近浦裕斗, 西真生, 藤原章雄, 菰原 義弘, 竹屋元裕, 中西義孝
  • Organizer: 日本機械学会2015年度年次大会
  • Place of Presentation: 北海道大学（札幌市）
  • Year and Date: 2015-09-13
• [Presentation] Textured surface of Co-Cr-Mo alloy affects wear characteristics of ultra-high molecular weight polyethylene in total joint replacement (2015)
  • Author(s): Naoki NISHI, Hiroto CHIKAURA, Haruyuki MASAOKA, Riku YOSHIOKA, Yuta NAKASHIMA, Yukio FUJIWARA,Yoshihiro KOMOHARA, Motohiro TAKEYA, Hiroshi MIZUTA, Yoshitaka NAKANISHI
  • Organizer: Japan-the Netherlands Symposium on Soft-Tribology
  • Place of Presentation: Kumamoto University（熊本市）
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] The size of wear debris in total joint replacement affects cytokine release from macrophages (2015)
  • Author(s): Hiroto CHIKAURA, Naoki NISHI, Riku YOSHIKA, Haruyuki MASAOKA, Yuta NAKASHIMA, Yukio FUJIWARA, Yoshihiro KOMOHARA, Motohiro TAKEYA, Hiroshi MIZUTA, Yoshitaka NAKANISHI
  • Organizer: Japan-the Netherlands Symposium on Soft-Tribology
  • Place of Presentation: Kumamoto University（熊本市）
  • Year and Date: 2015-09-10
  • Int'l Joint Research
• [Presentation] Micro Slurry-Jet Erosion for Processing to Bearing Surface of Artificial Joint (2015)
  • Author(s): Yoshitaka Nakanishi, Yuta Nakashima, Hiroto Chikaura, Naoki Nishi, Yukio Fujiwara, Motohiro Takeya, Yukihide Iwamoto, Hiroshi Mizuta, Hiromasa Miura, Hidehiko Higaki
  • Organizer: 2nd Pan Pacific Orthopaedic Congress
  • Place of Presentation: Hawaii, USA
  • Year and Date: 2015-07-22
  • Int'l Joint Research
• [Presentation] Precision surface machining on artificial joint bearing surfaces to inhibit macrophage activation (2015)
  • Author(s): Y.Nakanishi, N.Nishi, H.Chikaura, K.Kuwahata, Y.Nakashima, T.Matsubara, K.Murase, H.Miura, H.Higaki
  • Organizer: 20th International Conference on Wear of Materials
  • Place of Presentation: Tronto, Canada
  • Year and Date: 2015-04-12
  • Int'l Joint Research
• [Presentation] Micro Slurry-jet ErosionによるテクスチャリングがUHMWPEの摩耗に与える影響 (2015)
  • Author(s): 西真生，桑畑佳月，近浦裕斗，中島雄太，日垣秀彦，中西義孝
  • Organizer: 日本機械学会九州支部講演論文集, [No.158－1], p.35-36
  • Place of Presentation: 福岡大学工学部（福岡県・福岡市）
  • Year and Date: 2015-03-13
• [Presentation] 人工関節用ポリエチレン摩耗粉からの生体反応を抑制する摩擦面加工方法 (2015)
  • Author(s): 中西義孝、西真生、近浦裕北、桑畑佳月、中島雄太、日垣秀彦
  • Organizer: 日本機械学会第２７回バイオエンジニアリング講演会論文集、N0.14-67、pp.151-152
  • Place of Presentation: 朱鷺メッセ（新潟県・新潟市）
  • Year and Date: 2015-01-09 – 2015-01-10
• [Presentation] 生態工学、生体工学、そして生体模倣工学 ~ それぞれの実践的利用例の紹介 ~ (2014)
  • Author(s): 中西義孝
  • Organizer: 第4回医工連携マッチングセミナー
  • Place of Presentation: 熊本市国際交流会館（熊本県・熊本市）
  • Year and Date: 2014-12-09
  • Invited
• [Presentation] Co-Cr-Mo合金への表面テクスチャリングが超高分子量ポリエチレンの摩耗粉とサイトカインの反応性に与える影響 (2014)
  • Author(s): 西真生，桑畑佳月，近浦裕斗，中島雄太，藤原章雄，日垣秀彦，三浦裕正，岩本幸英，竹谷元裕，中西義孝
  • Organizer: 第41回日本臨床バイオメカニクス学会 プログラム・抄録集 p166
  • Place of Presentation: 奈良県新公会堂（奈良県・奈良市）
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] 生体反応を抑制できる人工関節面の加工法 (2014)
  • Author(s): 中西義孝、中島雄太、藤原章雄、近浦裕斗、西真生、桑畑佳月、大西紘二、薮原義弘、竹谷元裕
  • Organizer: 第35回バイオメカニズム学術講演会予稿集
  • Place of Presentation: 岡山大学（岡山県・岡山市）
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] 整形外科領域におけるCAD、FEA、RPおよびCAMの連携活用事例 (2014)
  • Author(s): 中西義孝
  • Organizer: LS-DYNA & JSTAMPフォーラム2014
  • Place of Presentation: ANAクラウンプラザホテルグランコート名古屋（愛知県・名古屋市）
  • Year and Date: 2014-10-29
  • Invited
• [Presentation] 人工関節摺動面で生じた超高分子量ポリエチレン摩耗粉がマクロファージ活性に与える影響 (2014)
  • Author(s): 近浦裕斗、中西義孝
  • Organizer: 第2回熊本大学医工連携フォーラム
  • Place of Presentation: 熊本大学医学部（熊本県・熊本市）
  • Year and Date: 2014-10-29
• [Presentation] 人工関節摺動面の表面加工とその効果 (2014)
  • Author(s): 桑畑佳月、中西義孝
  • Organizer: 第2回熊本大学医工連携フォーラム
  • Place of Presentation: 熊本大学医学部（熊本県・熊本市）
  • Year and Date: 2014-10-29
• [Presentation] 人工関節摺動面の定量的評価 (2014)
  • Author(s): 西真生、中西義孝
  • Organizer: 第2回熊本大学医工連携フォーラム
  • Place of Presentation: 熊本大学医学部（熊本県・熊本市）
  • Year and Date: 2014-10-29
• [Presentation] Soft-Tribology; Practical applications for Human Activity and Environmentally Sustainable Technology (2014)
  • Author(s): Yoshitaka NAKANISHI
  • Organizer: Keynote Lecture, University of Pittsburgh
  • Place of Presentation: University of Pittsburgh (PA, USA)
  • Year and Date: 2014-10-15
  • Invited
• [Presentation] Relationship between surface profiles of Co-Cr-Mo alloy bearings in artificial joints and the morphological aspects of wear particles generated from a ultra-high moreculular weight polyethylene insert (2014)
  • Author(s): Naoki Nishi, Hiroto Chikaura, Katsuki Kuwahata, Yuta Nakashima, Yukio Fujiwara, Toru Matsubara, Hiromasa Miura, Hidehiko Higaki, Hiroshi Mizuta, Yukihide Iwamoto, Yoshitaka Nakanishi
  • Organizer: The 4th Asian Conference on Engineering Education 2014, p339-340
  • Place of Presentation: Kumamoto University（Kumamoto,Japan）
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] The evaluation of cytotoxicity ultra-high molecular weight polyethylene (UHMWPE) wear particles generated from artificial joint surfaces (2014)
  • Author(s): Hiroto Chikaura, Naoki Nishi, Katsuki Kuwahara, Yuta Nakashima, Yukio Fujiwara, Hiromasa Miura, Hidehiko Higaki, Hiroshi Mizuta, Yukihide Iwamoto, Yoshitaka Nakanishi
  • Organizer: The 4th Asian Conference on Engineering Education 2014, p335-336
  • Place of Presentation: Kumamoto University（Kumamoto,Japan）
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Micro slurry-jet erosion method changes the surface profile of Co-Cr-Mo alloy used in artificial joints and wear characterisrics of ultra-high molecular weight polyethylene as a counterface material (2014)
  • Author(s): Katsuki Kuwahata, Naoki Nishi, Hiroto Chikaura, Yuta Nakashima, Yukio Fujiwara, Toru Matsubara, Hiromasa Miura, Hidehiko Higaki, Hiroshi mizuta, Yukihide Iwamoto, Yoshitaka Nakanishi
  • Organizer: The 4th Asian Conference on Engineering Education 2014, p337-338
  • Place of Presentation: Kumamoto University（Kumamoto,Japan）
  • Year and Date: 2014-10-10 – 2014-10-12
• [Presentation] Micro Slurry-jet Erosionにより処理した人工関節表面性状が摩耗粉形態に与える影響 (2014)
  • Author(s): 桑畑佳月，西真生，近浦裕斗，中島雄太，中西義孝
  • Organizer: 日本機械学会 第25回バイオフロンティア講演会講演論文集 [No.14-51]
  • Place of Presentation: とりぎん文化会館（鳥取県・鳥取市）
  • Year and Date: 2014-10-03 – 2014-10-04
• [Presentation] Precision Surface Machining of Artificial Joint Bearing Surfaces to Inhibit Macrophage Activation (2014)
  • Author(s): Yoshitaka Nakanishi, Naoki Nishi, Hiroto Chikaura, Katsuki Kuwahata, Yuta Nakashima, Kohei Murase, Hiromasa Miura, Hidehiko Higaki, Hiroshi Mizuta, Yukihide Iwamoto
  • Organizer: International Society for Technology in Arthroplasty(ISTA) 2014 Kyoto abstracts
  • Place of Presentation: Hotel Ohkura Kyoto (Kyoto, Japan)
  • Year and Date: 2014-09-24 – 2014-09-27
• [Presentation] The Effect of Texturing Co-Cr-Mo Alloy Surfaces Upon UHMWPE Wear Particle Size (2014)
  • Author(s): Naoki Nishi, Hiroto Chikaura, Katsuki Kuwahata, Toru Matubara, Yuta Nakashima, Yoshitaka Nakanishi
  • Organizer: International Society for Technology in Arthroplasty(ISTA) 2014 Kyoto abstracts
  • Place of Presentation: Hotel Ohkura Kyoto (Kyoto, Japan)
  • Year and Date: 2014-09-24
• [Presentation] 人工関節への MSE を利用した表面テクスチャリングについての研究 (2014)
  • Author(s): 西真生，近浦裕斗，中島雄太，松原亨，日垣秀彦，三浦裕正，水田博志，岩本幸英，中西義孝
  • Organizer: 日本機械学会 2014年度年次大会 DVD講演論文集 J0230201
  • Place of Presentation: 東京電機大学（東京都）
  • Year and Date: 2014-09-07 – 2014-09-10
• [Presentation] A nano-textured Co-Cr-Mo alloy surface, and its effect on bio-activity and UHMWPE wear particles (2014)
  • Author(s): Hiroto Chikaura, Naoki Nishi, Yuta Nakashima, Toru Matsubara, Hiromasa Miura, Hidehiko Higaki, Hiroshi Mizuta, Yukihide Iwamoto, Yoshitaka Nakanishi
  • Organizer: IUMRS-ICA 2014 Abstracts, B3-P28-002
  • Place of Presentation: Fukuoka Universuty (Fukuoka, Japan)
  • Year and Date: 2014-08-24 – 2014-08-30
• [Presentation] Application of Micro Slurry Erosion to Bearing Surface in Artificial Joint to Inhibit Macrophage Activation (2014)
  • Author(s): Yoshitaka Nakanisi, Yuta Nakashima, Naoki Nishi, Hiroto Chikaura, Katuki Kuwahata, Toru Matsubara, Higaki Hidehiko, Takeshi Shimoto, Yoshitaka Shiraishi, Taketoshi Umeno, Hiroshi Mizuta, Hiromasa Miura, Yukihide Iwamoto
  • Organizer: 2014 ICJR Pan Pacific Congress
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-07-16 – 2014-07-19
• [Presentation] Influences of textured surfaces on the wear properties of load bearings in artificial joints (2014)
  • Author(s): Hiroto Chikaura, Yuta Nakashima, Toru Matsubara, Hiromasa Miura, Hidehiko Higaki, Hiroshi Mizuta, Yukihide Iwamoto, Yoshitaka Nakanishi
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, Massachusetts, USA
  • Year and Date: 2014-07-06 – 2014-07-11
• [Presentation] Bearing Surface with Nanometer-scale Geometry Inhibits Tissue Reaction in Joint Prosthesis (2014)
  • Author(s): Y.Nakanishi, Y.Nakashima, N.Nishi, H.chikaura, T.Matsubara, H.higaki
  • Organizer: 7th World Congress of Biomechanics
  • Place of Presentation: Boston, Massachusetts, USA
  • Year and Date: 2014-07-06 – 2014-07-11
• [Presentation] 人工関節摺動面で生じるUHMWPE摩耗粉の調査と細胞に与える影響 (2014)
  • Author(s): 近浦裕斗，西真生，中島雄太，三浦裕正，日垣秀彦，水田博志，岩本幸英，中西義孝
  • Organizer: 平成26年度日本生体医工学会九州支部学術講演会
  • Place of Presentation: 九州工業大学飯塚キャンパス：福岡県飯塚市
• [Presentation] MSEを利用した人工関節摺動面への表面性状付与についての研究 (2014)
  • Author(s): 西真生，近浦裕斗，中島雄太，松原亨，三浦裕正，日垣秀彦，水田博志，岩本幸英，中西義孝
  • Organizer: 平成26年度日本生体医工学会九州支部学術講演会
  • Place of Presentation: 九州工業大学飯塚キャンパス：福岡県飯塚市
• [Presentation] 生体内における 6 自由度動態解析に基づく膝前十字靱帯 length patterns の評価 (2014)
  • Author(s): 白石善孝,西松和穂,日野和典,三浦裕正,池部怜,日垣秀彦,中西義孝
  • Organizer: 第26回バイオエンジニアリング講演会
  • Place of Presentation: 東北大学片平キャンパス：宮城県仙台市
• [Presentation] 健常股関節を対象とした回旋動作時の動態解析 (2014)
  • Author(s): 池部怜,手島祐太郎,日垣秀彦,白石善孝,下戸健,中西義孝,原大介,濵井敏,中島康晴,岩本幸英
  • Organizer: 第26回バイオエンジニアリング講演会
  • Place of Presentation: 東北大学片平キャンパス：宮城県仙台市
• [Presentation] 人工関節摺動面パターンがUHMWPE 摩耗粉形態に及ぼす影響 (2014)
  • Author(s): 近浦裕斗，中島雄太，日垣秀彦，三浦裕正，水田博志，岩本幸英，中西義孝
  • Organizer: 第26回バイオエンジニアリング講演会
  • Place of Presentation: 東北大学片平キャンパス：宮城県仙台市
• [Presentation] Bearing surface with nanometer geometry inhibits macrophage activation in oint prostheses (2013)
  • Author(s): Y.Nakanishi, H.Higaki, T.SHimoto, Y.Shiraishi, T.Umeno, H.Mizuta, H.Miura, Y.Iwamoto
  • Organizer: 5th International Conference on Mechanics of Biomaterials and Tissues
  • Place of Presentation: Mélia Sitges Hotel Congress Centre: Sitges, Spain
• [Presentation] Bearng surface with nano-level geometry inhibits macrophase activation in joint prostheses (2013)
  • Author(s): Yoshitaka Nakanishi, Naoki Nishi, Yuuki HIkichi, Kenryo Shimazu, Yuta Nakanishi, Hiroshi Mizuta, Hiromasa Miura, Yukihide Iwamoto, Hidehiko Higaki
  • Organizer: The 15th Iternational Conference on Biomedical Engineering (ICBME 2013)
  • Place of Presentation: National University of Singapore: Singapore
• [Presentation] 人工関節の摩擦面表面研磨法とその硬化 (2013)
  • Author(s): 中西義孝、近浦裕斗、西真生
  • Organizer: 第34回バイオメカニズム講演会SOBIM2013
  • Place of Presentation: 国立障害者リハビリテーションセンター: 埼玉県所沢市
• [Presentation] Nano-Level Surface on Co-Cr-Mo Alloy to Inhibit Macrophage Activation in Artificial Joint (2013)
  • Author(s): Yoshitaka Nakanishi
  • Organizer: 26th International Society for thechnology in arthroplasty (ISTA)
  • Place of Presentation: Palm Beach, Florida, USA
• [Presentation] 人工関節置換術前後におけるスクワット動作時の動態解析 (2013)
  • Author(s): 池部怜、日垣秀彦、石川篤、下戸健、中西義孝、西松和補、白石善孝、石丸雅巳、三浦裕正
  • Organizer: 第40回日本臨床バイオメカニクス学会
  • Place of Presentation: 神戸国際会議場：兵庫県神戸市
• [Presentation] 人工関節摺動面パターンとポリエチレン摩耗粉形態の関連性 (2013)
  • Author(s): 近浦裕斗，日垣秀彦，三浦裕正，水田博志，岩本幸英，中西義孝
  • Organizer: 第24回バイオフロンティア講演会
  • Place of Presentation: 同志社大学室町キャンパス：京都府京都市
• [Presentation] 人工関節軸受面の加工方法と表面テクスチャの違いが摩耗特性に与える影響 (2013)
  • Author(s): 西真生，近浦裕斗，日垣秀彦，三浦裕正，水田博志，岩本幸英，中西義孝
  • Organizer: トライボロジー会議
  • Place of Presentation: アクロス福岡：福岡県福岡市
• [Presentation] 人工関節摺動面処理におけるマイクロスラリーエロージョン適用の可能性 (2013)
  • Author(s): 西真生，中西義孝，日垣秀彦，三浦裕正，水田博志，岩本幸英
  • Organizer: 生体医工学シンポジウム
  • Place of Presentation: 九州大学伊都キャンパス：福岡県福岡市
• [Presentation] 人工関節摺動面の表面テクスチャリングがポリエチレン摩耗粉形態に与える影響 (2013)
  • Author(s): 近浦裕斗，日垣秀彦，三浦裕正，水田博志，岩本幸英，中西義孝
  • Organizer: 生体医工シンポジウム
  • Place of Presentation: 九州大学伊都キャンパス：福岡県福岡市
• [Presentation] 生体適合性ポリマーとトライボロジー (2013)
  • Author(s): 中西義孝
  • Organizer: バイオマテリアル学会九州講演会
  • Place of Presentation: 熊本大学黒髪キャンパス：熊本県熊本市
  • Invited
• [Book] Pan Stanford Publishing (2015)
  • Author(s): Y.Nakanishi
  • Total Pages: 160
  • Publisher: Hydrated Materials: Applications in Biomedicine and the Environment
• [Book] Hydrated Materials: Applications in Biomedicine and Environment (2015)
  • Author(s): Y.Nakanishi
  • Total Pages: 350
  • Publisher: Pan Stanford Publishing
• [Remarks] 研究室ＨＰ
  • URL: http://www.mech.kumamoto-u.ac.jp/Info/lab/biomech/Welcome.html
• [Remarks] 研究者webページ
  • URL: http://www.mech.kumamoto-u.ac.jp/Info/lab/biomech/Welcome.html
• [Remarks] 研究室ホームページ
  • URL: http://www.mech.kumamoto-u.ac.jp/Info/lab/biomech/Welcome.html
• [Remarks] 研究成果公開ホームページ
  • URL: http://www.mech.kumamoto-u.ac.jp/Info/lab/biomech/
• [Patent(Industrial Property Rights)] 摩擦部構造及び摩擦面の形成方法 (2014)
  • Inventor(s): 中西義孝、有福達治、清柳典子
  • Industrial Property Rights Holder: 中西義孝、有福達治、清柳典子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-138065
  • Filing Date: 2014-07-03
• [Funded Workshop] Innovative Symposium on Surface Engineering (2016)
  • Place of Presentation: Kumamoto University, Kumamoto
  • Year and Date: 2016-12-20
• [Funded Workshop] Japan-the Netherlands Symposium on Soft-Tribology (2015)
  • Place of Presentation: 熊本大学
  • Year and Date: 2015-09-10