| Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Outline of Final Research Achievements |
In a polymer-on-hard artificial joint, the bearing parts are typically composed of an ultra-high molecular weight polyethylene and an alloy with good corrosion resistance, or polyethylene and a ceramic. Wear debris generated from the polyethylene part is considered a major factor in long-term osteolysis and loosening of artificial joints, because the presence of this debris stimulates macrophage activity, thereby promoting the production of cytokines. To control the specific wear rate and morphological features of wear debris of the polyethylene, micro slurry-jet erosion was used as a precision machining method for the bearing surface of a Co-Cr-Mo alloy. Pin-on-disc wear tests resulted in a decrease in the polyethylene wear and changes in the morphological features. Primary human peripheral blood mononuclear phagocytes were incubated with the debris, and the wear debris generated on the textured surface reduced the secretion of the IL-6 proinflammatory cytokines.
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