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Emerging functions of electrically induced bubble injection device

Research Project

Project/Area Number 25289059
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionShibaura Institute of Technology

Principal Investigator

Yamanishi Yoko  芝浦工業大学, 工学部, 准教授 (50384029)

Co-Investigator(Kenkyū-buntansha) KAWAHARA Tomohiro  九州工業大学, 学内共同利用施設等, 准教授 (20575162)
AKAGI Satoshi  国立研究開発法人農業・食品産業技術総合研究機構, その他部局等, 研究員 (70414696)
Co-Investigator(Renkei-kenkyūsha) HIGASHIYAMA Tetsuya  名古屋大学, 理学研究科, 教授 (00313205)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywordsマイクロナノバブル / キャビテーション / 圧壊 / インジェクション / 精密加工 / マイクロ加工 / マイクロバブル / バイオMEMS / マイクロTAS / 知能機械学 / マイクロナノ気泡 / 遺伝子導入 / インジェクション技術 / 三次元加工
Outline of Final Research Achievements

For this research, we have successfully invented and operated electrically-induced bubble injector based on the directional micro-bubble flow. The novelty is the simultaneous perforation and transportation of reagent. Although the invasiveness is depends on the hardness of object, the device has succeeded in injection to plant tissue which used to be very difficult to be injected. This injection device has achieved to inject to the various hardness of material with higher dynamic range. This injection method can contribute to wide range of research fields such as gene therapy and direct gene injection to biological materials of variety hardness.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (56 results)

All 2016 2015 2014 2013 Other

All Journal Article (4 results) (of which Acknowledgement Compliant: 3 results,  Peer Reviewed: 3 results) Presentation (43 results) (of which Int'l Joint Research: 7 results,  Invited: 9 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] 電界誘起気泡による針なし注射器2015

    • Author(s)
      山西陽子
    • Journal Title

      自動車技術

      Volume: 69 Pages: 86-97

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 電界・プラズマを利用したマイクロバブル射出による細胞加工2015

    • Author(s)
      山西陽子
    • Journal Title

      日本機械学会誌

      Volume: 117 Pages: 28-31

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 電界誘起気泡メスと機能性界面2015

    • Author(s)
      山西陽子
    • Journal Title

      生体の科学

      Volume: 65 Pages: 510-511

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Local Ablation of a Single Cell Using Micro/Nano Bubbles2013

    • Author(s)
      Hiroki Kuriki, Yoko Yamanishi, Shinya Sakuma, Satoshi Akagi, Fumihito Arai
    • Journal Title

      Journal of Robotics and Mechatronics

      Volume: 25-3 Pages: 476-483

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Emerging Functions of Electrically-induced Bubble Injector2016

    • Author(s)
      Yoko Yamanishi
    • Organizer
      11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
    • Place of Presentation
      Matsushima Bay and Sendai MEMS City, Japan
    • Year and Date
      2016-04-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 皮膚深部への低侵襲インジェクション技術へ向けた基礎研究2016

    • Author(s)
      市川 啓太, 前田 真吾, 山西 陽子
    • Organizer
      第33回化学とマイクロ・ナノシステム研究会
    • Place of Presentation
      東京大学生産技術研究所,東京
    • Year and Date
      2016-04-26
    • Related Report
      2015 Annual Research Report
  • [Presentation] In-Situ Cellular-Scale Injection for Alive Plants by Micro-Bubble Injector2016

    • Author(s)
      Sohei Itabashi, Takuya Kambayashi, Takatoshi Shimamura, Kazuki Takahashi
    • Organizer
      11th IEEE Annual International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)
    • Place of Presentation
      Matsushima Bay and Sendai MEMS City, Japan
    • Year and Date
      2016-04-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プラズマ誘起気泡によるバイオメディカル応用2016

    • Author(s)
      山西 陽子
    • Organizer
      第63回応用物理学会春季学術講演会,特別シンポジウム
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2016-03-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] High Dynamic Ablation and Injection by Electric Cavitation for Wide Range of Materials2016

    • Author(s)
      Kazuki Takahashi, Yuta Arakawa, and Yoko Yamanishi
    • Organizer
      The 28th International Conference on Micro Electro Mechanical Systems (MEMS2016)
    • Place of Presentation
      Shanghai, CHINA
    • Year and Date
      2016-01-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple-reagent Layer Laden High-speed Micro-bubbles in Extended Two-dimensional Microchip2015

    • Author(s)
      Yohei Hamano, Takuya Kambayashi, Yoko Yamanishi
    • Organizer
      2015 International Symposium on Micro-NanoMechatronics and Human Science (MHS2015)
    • Place of Presentation
      Nagoya Univ, JAPAN
    • Year and Date
      2015-11-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] プラズマ気泡による新液中マイクロ加工と力計測2015

    • Author(s)
      荒川 佑太,辻本 大介,山西 陽子
    • Organizer
      第32回 「センサ・マイクロマシンと応用システム」シンポジウム(電気学会)
    • Place of Presentation
      朱鷺メッセ, 新潟
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電界誘起気泡を用いた卵母細胞クローニング技術への研究2015

    • Author(s)
      嶋村 恭敏,高橋 和基,山西 陽子
    • Organizer
      日本機械学会第7回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      朱鷺メッセ, 新潟
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 3 次元マイクロアレイ電極誘起気泡によるインジェクションデバイス2015

    • Author(s)
      神林 卓也,濱野 洋平,山西 陽子
    • Organizer
      日本機械学会第7回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      朱鷺メッセ, 新潟
    • Year and Date
      2015-10-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電界誘起バブルインジェクターによる多種生体試料への試薬パターニング2015

    • Author(s)
      高橋 和基,山西 陽子
    • Organizer
      第39 回静電気学会全国大会
    • Place of Presentation
      首都大学東京,東京
    • Year and Date
      2015-09-25
    • Related Report
      2015 Annual Research Report
  • [Presentation] Processing Biological Material by Combination of Cavitation and Plasma Irradiation2015

    • Author(s)
      Yuta Arakawa, Yuki Sasagawa, Daisuke Tsujimoto, Yoko Yamanishi
    • Organizer
      AEPSE2015
    • Place of Presentation
      JEJU, Korea
    • Year and Date
      2015-09-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rounding of Protein Crystal by High-Speed Bubble Jet in Microfluidic Chip2015

    • Author(s)
      Takudo Shu, Takasawa, Yoko Yamanishi
    • Organizer
      ISMM 2015
    • Place of Presentation
      Kyoto, JAPAN
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transportation of Multiple-reagent Using Adsorption and Contraction Force of Micro-bubble2015

    • Author(s)
      Yohei Hamano, Takuya Kambayashi, Yoko Yamanishi
    • Organizer
      ISMM 2015
    • Place of Presentation
      Kyoto, JAPAN
    • Year and Date
      2015-06-08
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マイクロアレイ電極による多筒式インジェクション2015

    • Author(s)
      神林 卓也,濱野 洋平, 山西 陽子
    • Organizer
      ROBOMECH 2015 in Kyoto
    • Place of Presentation
      みやこめっせ,京都
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 針なし気泡注射器による試薬インジェクション2015

    • Author(s)
      高橋 和基,山西 陽子
    • Organizer
      ROBOMECH 2015 in Kyoto
    • Place of Presentation
      みやこめっせ,京都
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] プラズマ誘起気泡の圧壊による新液中マイクロ加工2015

    • Author(s)
      荒川 佑太, 大村 実樹子,辻本 大介,山西 陽子
    • Organizer
      ROBOMECH 2015 in Kyoto
    • Place of Presentation
      みやこめっせ,京都
    • Year and Date
      2015-05-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] 電界誘起気泡による機能創発2015

    • Author(s)
      山西 陽子
    • Organizer
      No14-173 バイオロボティクス 特別講演会, 日本機械学会
    • Place of Presentation
      信州大学繊維学部
    • Year and Date
      2015-02-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Emerging Functions of Electrically-induced Bubble Knife2015

    • Author(s)
      Yoko Yamanishi
    • Organizer
      水素先端世界フォーラム2015(HYDROGENIUS研究シンポジウム)
    • Place of Presentation
      九州大学伊都キャンパス
    • Year and Date
      2015-02-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Carving of Protein Crystal by High-speed Micro-bubble Jet Using Micro-fluidic Platform2015

    • Author(s)
      So Takasawa, Takudo Shu, Yoko Yamanishi
    • Organizer
      The 28th International Conference on Micro Electro Mechanical Systems (MEMS2015)
    • Place of Presentation
      エストリル,ポルトガル
    • Year and Date
      2015-01-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] Minimally Invasive Needle-free Bubble Injector for Gene Therapy2015

    • Author(s)
      Kazuki Takahashi, Shun Omi, Yoko Yamanishi
    • Organizer
      The 28th International Conference on Micro Electro Mechanical Systems (MEMS2015)
    • Place of Presentation
      エストリル,ポルトガル
    • Year and Date
      2015-01-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 電界・プラズマを利用したマイクロバブル射出による機能創発2014

    • Author(s)
      山西 陽子
    • Organizer
      第7回超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      横浜国大
    • Year and Date
      2014-12-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 多筒式電極誘起気泡による二次元試薬インジェクション2014

    • Author(s)
      神林 卓也,濱野 洋平,山西 陽子
    • Organizer
      日本機械学会第6回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      松江,島根
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] 多層界面を有する気泡生成デバイス2014

    • Author(s)
      濱野洋平,神林卓也,山西 陽子
    • Organizer
      日本機械学会第6回マイクロ・ナノ工学シンポジウム
    • Place of Presentation
      松江,島根
    • Year and Date
      2014-11-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Minimally-invasive Local Injection by Electrically-driven Narrow Orifice Channel2014

    • Author(s)
      Kazuki Takahashi, Shun Omi, Yoko Yamanishi
    • Organizer
      International Symposium on Micro-NanoMechatronics and Human Science (MHS2014)
    • Place of Presentation
      Nagoya Univ, Japan
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 電界誘起気泡メスによる機能創発2014

    • Author(s)
      山西 陽子
    • Organizer
      日本機械学会熱工学部門,熱工学カンファレンス
    • Place of Presentation
      芝浦工大豊洲キャンパス
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Micro-bubble Ring Generation by Electrically-driven High-speed Bubble Strike under Micro-fluidic Environment2014

    • Author(s)
      S. Takasawa, Y. Fujiwara, T. Kobayashi, M. Oomura, H. Kamegawa, and Y. Yamanishi
    • Organizer
      18th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (micro-TAS 2014)
    • Place of Presentation
      サンアントニオ,アメリカ
    • Year and Date
      2014-10-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] Electrically Induced Bubble Capillary-poration2014

    • Author(s)
      K. Takahashi, W. Kawaguchi, Y. Hamano, S. Hosoda, Y. Arakawa, and Y. Yamanishi
    • Organizer
      18th Int. Conf. on Miniaturized Systems for Chemistry and Life Sciences (micro-TAS 2014)
    • Place of Presentation
      サンアントニオ,アメリカ
    • Year and Date
      2014-10-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 微小空間における渦輪生成への研究2014

    • Author(s)
      高澤曹,山西陽子
    • Organizer
      第30回化学とマイクロナノシステム研究会
    • Place of Presentation
      札幌,北海道
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 気泡帯電局所破壊によるウシ卵子の低侵襲加工2014

    • Author(s)
      川口航,高橋和基,山西陽子
    • Organizer
      第30回化学とマイクロナノシステム研究会
    • Place of Presentation
      札幌,北海道
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] 磁気タグインジェクションによる細胞情報トレーシング2014

    • Author(s)
      藤原裕也,石川博康,山西陽子
    • Organizer
      第30回化学とマイクロナノシステム研究会
    • Place of Presentation
      札幌,北海道
    • Year and Date
      2014-10-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Emergent Functions of Electrically-Induced Bubbles2014

    • Author(s)
      山西 陽子
    • Organizer
      IUMRS-ICA2014
    • Place of Presentation
      福岡大学
    • Year and Date
      2014-08-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 微小空間放電による気液界面生成の研究2014

    • Author(s)
      富田貴直, ○高澤曹,栗木宏樹,新井史人, 山西陽子
    • Organizer
      ROBOMECH 2014 in Toyama, (社)日本機械学会ロボメカ部門
    • Place of Presentation
      富山
    • Year and Date
      2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 気液界面輸送による局所遺伝子導入2014

    • Author(s)
      高橋 和基,栗木 宏樹,新井 史人, 山西 陽子
    • Organizer
      ROBOMECH 2014 in Toyama, (社)日本機械学会ロボメカ部門
    • Place of Presentation
      富山
    • Year and Date
      2014-05-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] “微小空間内放電による流れ場と局所試薬輸送”2014

    • Author(s)
      高橋和基,濱野洋平,細田駿介,荒川佑太,山西陽子
    • Organizer
      第29回化学とマイクロナノシステム研究会
    • Place of Presentation
      日本女子大学,東京
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Local injection using regent-laden micro-bubbles2014

    • Author(s)
      S. Takasawa, K. Takahashi, H. Kuriki, F. Arai, Y. Yamanishi
    • Organizer
      5th International conference on Plasma Medicine (ICPM5)
    • Place of Presentation
      Nara, JAPAN
    • Year and Date
      2014-05-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Electrically-induced bubble knife for protein crystallization and processing

    • Author(s)
      Hiroki Kuriki, Sou Takasawa, Genji Kurisu, Fumihito Arai, Yoko Yamanishi
    • Organizer
      IEEE MHS2013
    • Place of Presentation
      名古屋大学,名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Protein Crystallization Induced by Electrically Driven Bubble Knife

    • Author(s)
      H. Kuriki, S. Takasawa, S. Sakuma, K. Shinmura, G. Kurisu, F. Arai, Y. Yamanishi
    • Organizer
      MicroTAS2013
    • Place of Presentation
      フライブルク,ドイツ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Multiphase-laden Gas-liquid Interface Injection for the Versatile Gene Transfer

    • Author(s)
      H. Kuriki, S. Takasawa, M. Iwabuchi, K. Ohsumi, T. Suzuki, T. Higashiyama, S. Sakuma, F. Arai, and Y. Yamanishi
    • Organizer
      MicroTAS2013
    • Place of Presentation
      フライブルク,ドイツ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電界誘起による機能創発

    • Author(s)
      山西陽子
    • Organizer
      東北大学電気通信研究所共同プロジェクト研究会
    • Place of Presentation
      東北大学,仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 細胞操作技術の新展開

    • Author(s)
      山西陽子
    • Organizer
      第17回バイオレオロジー・リサーチ・フォーラム
    • Place of Presentation
      九州大学,福岡
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Protein crystallization by electrically-induced bubble

    • Author(s)
      高澤 曹, 栗木 宏樹, 新井史人,山西 陽子
    • Organizer
      第28回化学とマイクロナノシステム研究会
    • Place of Presentation
      姫路
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電界誘起型マイクロバブルメスによる細胞への試薬導入

    • Author(s)
      栗木宏樹,山西陽子,佐久間臣耶,鈴木孝征,東山哲也,新井史人
    • Organizer
      Robomec2013
    • Place of Presentation
      筑波
    • Related Report
      2013 Annual Research Report
  • [Presentation] 微小空間内放電による流れ場と局所試薬輸送

    • Author(s)
      高橋 和基,濱野洋平,細田駿介,荒川佑太,山西 陽子
    • Organizer
      第29回化学とマイクロナノシステム研究会
    • Place of Presentation
      日本女子大学,東京
    • Related Report
      2013 Annual Research Report
  • [Book] 日本機械学会誌2014年7月号2014

    • Author(s)
      山西陽子
    • Total Pages
      3
    • Publisher
      日本機械学会
    • Related Report
      2013 Annual Research Report
  • [Remarks] 芝浦工業大学山西研究室

    • URL

      http://www.sic.shibaura-it.ac.jp/~yoko/

    • Related Report
      2015 Annual Research Report
  • [Remarks]

    • URL

      http://www.sic.shibaura-it.ac.jp/~yoko/

    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 気泡噴出チップ、局所アブレーション装置及び局所アブレーション方法、並びにインジェクション装置及びインジェクション方法2015

    • Inventor(s)
      山西陽子,神林卓也,高橋和基
    • Industrial Property Rights Holder
      芝浦工業大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-205948
    • Filing Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 気泡噴出部材、気液噴出部材、局所アブレーション装置及び局所インジェクション装置2014

    • Inventor(s)
      山西 陽子,高橋 和基, 小見 駿
    • Industrial Property Rights Holder
      JST
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-226699
    • Filing Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 有機結晶加工用チップ、有機結晶回転装置及び有機結晶加工装置2014

    • Inventor(s)
      山西 陽子,高澤 曹, 周 澤道
    • Industrial Property Rights Holder
      JST
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-213243
    • Filing Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 渦輪発生装置、該渦輪発生装置を含む洗浄装置2014

    • Inventor(s)
      山西 陽子,高澤 曹
    • Industrial Property Rights Holder
      JST
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-201439
    • Filing Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] 気泡噴出チップ、局所アブレーション装置及び局所アブレーション方法、並びにインジェクション装置及びインジェクション方法2014

    • Inventor(s)
      山西 陽子,濱野 洋平, 神林 卓也
    • Industrial Property Rights Holder
      JST
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-201440
    • Filing Date
      2014-09-30
    • Related Report
      2014 Annual Research Report
  • [Patent(Industrial Property Rights)] タンパク質結晶装置用の気泡噴出部材及びタンパク質吸着気泡噴出部材、 タンパク質結晶装置及びタンパク質結晶化方法、 並びにタンパク質結晶切削装置及びタンパク質結晶切削方法2013

    • Inventor(s)
      山西 陽子,栗木 宏樹,新井 史人
    • Industrial Property Rights Holder
      名古屋大学・JST
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-179848
    • Filing Date
      2013-08-30
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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