Biosensors based on a Si single-electron transistor for practical use

• Project/Area Number: 25289103
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Electron device/Electronic equipment
• Research Institution: Hiroshima University
• Principal Investigator: NAKAJIMA ANRI 広島大学, ナノデバイス・バイオ融合科学研究所, 准教授 (70304459)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000); Fiscal Year 2015: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: バイオセンサー / バイオデバイス / 単一電子トランジスタ / ＤＮＡ / 前立腺特異抗原

Outline of Final Research Achievements

Sensors utilizing field effect transistors (FETs) have attracted attention as bio and ion snsors. Single-electron transisotrs (SETs) are a promising candidate for achieving high detection sensitivity due to their Coulomb oscillation. In this study, the mechanism of ultra-sensitive biomolecule detection utilizing a SET sensor has been clarified by experimental and theoretical analyses. In addition, immunodetection of prostate-specific antigen(PSA) has been perfomed utilizing a SET sensor, demonstrating the suitability for practical use.

Research Products

• [Journal Article] Application of Single-Electron Transistor to Biomolecule and Ion Sensors (2016)
  • Author(s): Anri Nakajima
  • Journal Title: Applied Sciences Volume: 6 Issue: 4 Pages: 94-94
  • DOI: 10.3390/app6040094
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biomolecule detection based on Si single-electron transistors for practical use (2013)
  • Author(s): Anri Nakajima, Takashi Kudo, and Sadaharu Furuse
  • Journal Title: Applied Physics Letters Volume: 103 Issue: 4 Pages: 43702-43702
  • DOI: 10.1063/1.4816267
  • Peer Reviewed
• [Presentation] Applications of Si nanoscale dot to memory and sensor devices (2015)
  • Author(s): Anri Nakajima
  • Organizer: EMN Meeting on Vacuum Electronics
  • Place of Presentation: Las Vegas, NV, USA
  • Year and Date: 2015-11-21
  • Int'l Joint Research / Invited
• [Presentation] Biomolecule Sensing Based on a Single-electron Transistor (2015)
  • Author(s): Anri Nakajima
  • Organizer: EMN Phuket Meeting 2015 Energy Materials Nanotechnology
  • Place of Presentation: Phuket, Thailand
  • Year and Date: 2015-05-04
  • Int'l Joint Research / Invited
• [Presentation] Si単電子トランジスタを用いた高感度バイオセンサー (2014)
  • Author(s): 中島 安理, 工藤 貴史，古瀬 貞治
  • Organizer: 第61回応用物理学会春季学術講演会
  • Place of Presentation: 青山学院大学 相模原キャンパス
• [Presentation] Si単電子トランジスタを用いた前立腺特異抗原(PSA)の検出 (2014)
  • Author(s): 中島 安理, 工藤 貴史，古瀬 貞治
  • Organizer: 第61回応用物理学会春季学術講演会
  • Place of Presentation: 青山学院大学 相模原キャンパス
• [Presentation] Si Single-Electron Transistor based on Multiple Island and Its Applications (2013)
  • Author(s): Anri Nakajima
  • Organizer: 2013 Energy Materials Nanotechnology Fall Meeting
  • Place of Presentation: Orlando USA
  • Invited