| Budget Amount *help |
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
Manufacturing processing of “Protein-adsorbed Bio-implant” was constructed by the combination of engineering and biological techniques. Protein-adsorbed bio-implant did not have any surface coating layers, and the proteins, such as fibronectin, decorin, and albumin, adsorbed to implant surface directly. The protein-adsorbed bio-implants were subjected to in vivo testing using rats. The correlation between in vivo results and in vitro was examined. The kind of adsorbed protein to the bio-implants did not influence the osteoconductivity and the implants with any kinds of protein had high osteoconductivity. Protein adsorption rate to the implant surface at very early stage, which was affected by the hydrophilicity/hydrophobicity of implant surface, showed the strong correlation with the osteoconductivity.
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