| Budget Amount *help |
¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
Thin films (nanosheets) of tens nanometer thickness from medical polymers has been paid attention as an innovative medical material "nano-adhesive plaster" which can be adhered on the various surfaces of living body. This study aims to establish the fabrication process of multilayered nanosheets where drug micro/nano-crystals or nanodiscs are inserted between a barrier layer and a release layer. The drug permeability of various medical polymers was clarified by using fluorescent model drugs, and its control method was established by using penetrated phase separation. Furthermore, the multilayered nanosheets embedding antibiotic AgSD micro-crystals were prepared and showed significantly higher curing rate of infected partial-thickness burn injury in model mice.
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