Medical technological study of nano chemotherapy using hybrid liposomes for the refractory disease
| Project/Area Number |
25289299
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biofunction/Bioprocess
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| Research Institution | Sojo University |
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Principal Investigator |
UEOKA Ryuichi 崇城大学, 生物生命学部, 客員研究員 (70099076)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMOTO Yoko 崇城大学, 生物生命学部, 教授 (00133562)
MATSUSHITA Taku 崇城大学, 生物生命学部, 教授 (10209538)
GOTO Koichi 崇城大学, 生物生命学部, 教授 (30279377)
ICHIHARA Hideaki 崇城大学, 生物生命学部, 准教授 (70369114)
KOMIZU Yuji 崇城大学, 生物生命学部, 助教 (80735829)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Keywords | リポソーム / 癌 / エイズ / 細胞膜 / アポトーシス / 揺らぎ / 細胞・組織 / セラミド |
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| Outline of Final Research Achievements |
We have produced hybrid liposomes(HL)which can be prepared by sonication of vesicular and micellar molecules in a buffer solution.We investigated the anticancer and anti-AIDS effects of HL and following results are obtained.(A)The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro.(B)apoptotic induction pathway which targeted tumor cell membranes was observed.(C)Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL in vivo. Long-term selective accumulation of fluorescent labeled HL into tum or was observed in pharmacokinetics test using mice model of carcinoma. (D)therapetutic effects of treatment for the lymphoma with relation to AIDS was obtained.These findings suggest that HL should be a new type of nanomedicinal drug anti-cancer and anti-AIDS that targets refractory disease cell-membranes to trigger apoptotic cell death for various cancer cells.
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Report
(4 results)
Research Products
(31 results)
