| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2017: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
|---|
| Outline of Final Research Achievements |
The present study was designed to verify our hypothesis that an abnormal output from the basal ganglia to the brainstem-spinal cord causes posture-gait disturbance in basal ganglia disorders. For this purpose, we employed electrophysiological techniques combined with neuropharmacological assessments in decerebrate cats to examine how GABAergic output from the substantia nigra reticulata (SNr), one of the basal ganglia output nuclei, to the pedunculopontine tegmental nucleus (PPN) modulated activity descending brainstem-spinal cord motor pathways. Our results suggest that GABAergic SNr-PPN projection contribute to the posture-gait control by modulating the excitability of reticulospinal tract. Because the reticulospinal tract has dense connections with the vestibulospinal and monoaminergic tracts, the present results suggest that an abnormal activity in the SNr in basal ganglia motor disorders cause posture-gait disturbances by changing the excitability of brainstem-spinal cord systems.
|
