| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
To elucidate the population coding by individual synaptic inputs, we have developed a method for visualizing the activity of single synapse in vivo by using two-photon imaging. We have shown that both spontaneous and sensory-evoked synaptic inputs are synchronized at neighboring synapses, and that spatiotemporal pattern of sensory-evoked synaptic inputs are similar to that of spontaneous inputs. Furthermore, we showed that these pattern of synaptic inputs are shaped by sensory experience during critical period. We also showed that the probability of coincident inputs in awake condition is much higher than that under anesthesia, indicating that the spatiotemporal pattern of synaptic inputs contributes to nonlinear dendritic integration under physiological conditions.
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