| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
We analyzed the sleep-arousal mechanism of a fruit fly, Drosophila melanogaster, which has been noted as a model for sleep study. First, we identified NMDA glutamate receptor as a novel sleep regulating gene. This provides a clue to the relationship between sleep and memory. Next we found that artificial sweeteners, but not non-sweet nutritive saccharides, induced sleep in fasting flies. Activation of sweet-receptor expressing neurons also induced sleep. Arousal threshold, however, was not reversed in artificial sweetener-fed flies. These results suggests that sweetness facilitates the transition from arousal to sleep, while the nutritional state, i.e. satiety inhibits that from sleep to arousal. In addition, we found glycine induces sleep in flies similarly in mammals, re-confirming that fruit fly can serve as a good model animal for sleep study.
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