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Molecular basis of tactile response

Research Project

Project/Area Number 25290008
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionAoyama Gakuin University (2014-2015)
National Institute of Genetics (2013)

Principal Investigator

Hirata Hiromi  青山学院大学, 理工学部, 教授 (60402450)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Keywords遺伝学 / 神経科学 / 遺伝子 / 脳・神経
Outline of Final Research Achievements

We identified ring finger protein 121 (RNF121) as an endoplasmic reticulum-resident E3 ubiquitin ligase. The RNF121 regulates ubiquitination of voltage-gated sodium channel Nav1.6 and promotes its intracellular transport to a specific plasmamembrane region axon initial segment, where voltage-gated sodium channels form clusters. These results indicate that RNF121 is involved in the quality control of voltage-gated sodium channels and thus in mechanosensation and animal behavior.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (22 results)

All 2016 2015 2014 2013

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 1 results,  Acknowledgement Compliant: 3 results) Presentation (11 results) (of which Int'l Joint Research: 3 results,  Invited: 8 results) Book (2 results)

  • [Journal Article] RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels2015

    • Author(s)
      Ogino, K., Low, S.E., Yamada, K., Saint-Amant, L., Zhou, W., Muto, A., Asakawa, K., Nakai, J., Kawakami, K., Kuwada, J.Y., and Hirata, H.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 112 Issue: 9 Pages: 2859-2864

    • DOI

      10.1073/pnas.1414002112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuromuscular regulation in zebrafish by a large AAA+ ATPase/ubiquitin ligase, mysterin/RNF213.2015

    • Author(s)
      Kotani Y, Morito D, Yamazaki S, Ogino K, Kawakami K, Takashima S, Hirata H, Nagata K.
    • Journal Title

      Scientific Reports

      Volume: 5 Issue: 1 Pages: 16161-16161

    • DOI

      10.1038/srep16161

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures.2015

    • Author(s)
      Stödberg, T., McTague, A., Ruiz, A. J., Hirata, H. et al.
    • Journal Title

      Nat. Commun.

      Volume: 6 Issue: 1 Pages: 8038-8038

    • DOI

      10.1038/ncomms9038

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Coexpression of auxiliary K<sub>v</sub>β2 subunits with K<sub>v</sub>1.1 channels is required for developmental acquisition of unique firing properties sf zebrafish mauthner cells2014

    • Author(s)
      Takaki Watanabe,Takashi Shimazaki, Aoba Mishiro, Takako Suzuki, Hiromi Hirata, Masashi Tanimoto,Yoichi Oda
    • Journal Title

      Journal of Neurophysiology

      Volume: 111 Issue: 6 Pages: 1153

    • DOI

      10.1152/jn.00596.2013

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Defective escape behavior in DEAH-box RNA helicase mutants improved by restoring glycine receptor expression.2013

    • Author(s)
      Hirata, H., Ogino, K., Yamada, K., Leacock, S. and Harvey, R. J.
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 37 Pages: 14638-14644

    • DOI

      10.1523/jneurosci.1157-13.2013

    • Related Report
      2013 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Mutations of ZC4H2 are associated with arthrogryposis multiplex congenita and intellectual disability and through impairment of central and peripheral synaptic plasticity2013

    • Author(s)
      Hirata, H., Nanda, I., van Riesen, A., McMichael, G., Hu, H., Hambrock, M., Papon, M.-A., Fischer, U., Marouillat, S., Ding, C., Alirol, S., Bienek, M., Preisler-Adams, S., Grimme, A., Seelow, D., Webster, R., Haan, E., MacLennan, A., Stenzel, W., Yap, T. Y., Gardner, A., Nguyen, L. S., Shaw, M., Lebrun, N., Haas, S. A., Kress, W., Haaf, T., Schellenberger, E., Chelly, J., Viot, G., Shaffer, L. G., Rosenfeld, J. A., Kramer, N., Falk, R., El-Khechen, D., Escobar, L. F., Hennekam, R., Wieacker, P., Hubner, C., Ropers, H.-H., Gecz, J., Schuelke, M., Laumonnier, F. and Kalscheuer, V. M
    • Journal Title

      Am. J. Hum. Genet

      Volume: 92 Issue: 5 Pages: 681-695

    • DOI

      10.1016/j.ajhg.2013.03.021

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy.2013

    • Author(s)
      Horstick, E. J., Linsley, J. W., Dowling, J. J., Hauser, M. A., McDonald, K. K., Ashley-Koch, A., Saint-Amant, L., Satish, A., Cui, W. W., Zhou, W., Sprague, S. M., Stamm, D. S., Powell, C. M., Speer, M. C., Franzini-Armstrong, C., Hirata, H. and Kuwada, J. Y.
    • Journal Title

      Nat. Commun.

      Volume: 4 Issue: 1 Pages: 1952-1952

    • DOI

      10.1038/ncomms2952

    • Related Report
      2013 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Glycinergic transmission and postsynaptic activation of CaMKII are required for glycine receptor clustering in vivo2013

    • Author(s)
      Yamanaka I, Miki M, Asakawa K, Kawakami K, Oda Y, Hirata H
    • Journal Title

      Genes Cells

      Volume: 18(3) Issue: 3 Pages: 211-224

    • DOI

      10.1111/gtc.12032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons2013

    • Author(s)
      Satou, C., Kimura, Y., Hirata, H., Suster, M.L, Kawakami, K., and Higashijima, S.
    • Journal Title

      Development

      Volume: 140 Issue: 18 Pages: 3927-3931

    • DOI

      10.1242/dev.099531

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ゼブラフィッシュを用いた運動器の遺伝学的解析2016

    • Author(s)
      平田普三
    • Organizer
      第4回骨格筋生物学研究会
    • Place of Presentation
      松本大学
    • Year and Date
      2016-03-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] Plasticity of glycinergic synapses and related behaviors in zebrafish.2015

    • Author(s)
      Hirata, H., Ogino, K., Yamada, K., Leacock, S. and Harvey, R. J.
    • Organizer
      The 25th meeting of the International Society for Neurochemistry.
    • Place of Presentation
      Cairns Convention Center. Cairns, Australia.
    • Year and Date
      2015-08-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 電位依存性ナトリウムチャネルの輸送におけるGPIアンカータンパク生合成の重要性2015

    • Author(s)
      平田普三
    • Organizer
      第34回日本糖質学会年会
    • Place of Presentation
      東京大学安田講堂(東京)
    • Year and Date
      2015-08-02
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Plasticity of glycinergic synapse in zebrafish.2015

    • Author(s)
      Hirata, H., Ogino, K. and Yamada, K.
    • Organizer
      The 6th Strategic Conference of Zebrafish Investigators.
    • Place of Presentation
      Asilomar Conference Center. California, USA.
    • Year and Date
      2015-01-19
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Motor development and plasticity in zebrafish.2014

    • Author(s)
      Hirata, H., Ogino, K., Yamada, K., Leacock, S. and Harvey, R. J.
    • Organizer
      Core-to-Core Project International Seminar “Evolution of insulin-like peptides and their function: development, growth metabolism and aging.”
    • Place of Presentation
      東京大学中島董一郎記念ホール(東京)
    • Year and Date
      2014-10-11
    • Related Report
      2014 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 運動システムの遺伝的プログラムと可塑性~ゼブラフィッシュを用いた運動・行動の研究~2014

    • Author(s)
      平田普三
    • Organizer
      第6回Neuroprotective Meeting for Young Researchers
    • Place of Presentation
      シェラトン都ホテル東京(東京)
    • Year and Date
      2014-10-04
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ゼブラフィッシュの動きにおけるグリシン作動性シナプスの重要性2014

    • Author(s)
      平田普三
    • Organizer
      第20回関西小型魚類研究会定例会
    • Place of Presentation
      理化学研究所・生命システム研究センター大会議室(大坂)
    • Year and Date
      2014-01-24
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Formation of glycinergic synapse in zebrafish.2014

    • Author(s)
      Hirata, H.
    • Organizer
      The 6th Asia Oceania Zebrafish Meeting.
    • Place of Presentation
      Hong Kong University of Science and Technology(香港)
    • Year and Date
      2014-01-21
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] グリシン作動性シナプス可塑性の動作原理と生理的意義2013

    • Author(s)
      平田普三
    • Organizer
      国立遺伝学研究所研究会「哺乳類脳の機能的神経回路の構築メカニズム」
    • Place of Presentation
      国立遺伝学研究所講堂(三島)
    • Year and Date
      2013-12-20
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] DEAH-box RNA helicase Dhx37 plays an essential role in the biogenesis of GlyRa subunit mRNAs and is indispensable for normal escape behavior.2013

    • Author(s)
      Hirata, H., Ogino, K., Yamada, K., Leacock, S. and Harvey, R. J.
    • Organizer
      The 8th European Zebrafish Meeting.
    • Place of Presentation
      Palau de Congressos de Catalunya(バルセロナ)
    • Year and Date
      2013-07-12
    • Related Report
      2013 Annual Research Report
  • [Presentation] 発生期のグリシン作動性シナプスの活動依存的形成とその機能2013

    • Author(s)
      平田普三
    • Organizer
      熊本シンポジウム 2013
    • Place of Presentation
      熊本大学発生医学研究所(熊本)
    • Year and Date
      2013-06-25
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] 臨床神経科学 2015年(Vol. 33)1月号 グリシンとグリシン受容体の機能2015

    • Author(s)
      平田普三
    • Publisher
      中外医学社
    • Related Report
      2014 Annual Research Report
  • [Book] 別冊日本臨床 新領域別症候群シリーズ No. 29 神経症候群(第2版)Wieacker-Wolff症候群2014

    • Author(s)
      平田普三
    • Publisher
      日本臨床社
    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2017-05-10  

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