Analysis for epigenetic nechanims of genes selectively expressed in the primate neo cortex
| Project/Area Number |
25290011
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Institute of Physical and Chemical Research (2015)
National Institute for Basic Biology |
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Principal Investigator |
Yamamori Tetsuo 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (80260206)
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| Co-Investigator(Kenkyū-buntansha) |
Hata Katsusuke 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (20546692)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
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| Keywords | 大脳皮質 / 連合野 / 視覚野 / メチル化 / MBD4 / マカカ / 遺伝子発現 / 前頭葉 / 活動依存的発現 / 転写因子 / 一次視覚野 / 神経科学 / DNA |
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| Outline of Final Research Achievements |
By large scale analysis of genes selectively expressed in certain area in the primate neocortex, we had reported that such genes could be classified two groups: One is high in the association areas and the other is high in the primary visual cortex. We examined the promoter region of representative association and primary visual area selective genes and found high and low methylation revels,respectively. Furthermore, we found that MBP4, a member of MBPs, can control the association area selective genes of PNMA5 and RBP4 by GOF (gain of function) and LOF (loss of function) analysis.
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Report
(4 results)
Research Products
(6 results)
