| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Understanding the brain’s circuit architecture is critical to elucidating its function. We quantitatively analyzed synapse distribution on layer 5 pyramidal cell of rat cortex and found the cell receive totally about 20,000 synapses. About 20 % of them are inhibitory synapse. The inhibitory synapse junction size is varied and correlated with their target size. It probably acts for an efficient inhibition. We found that inhibitory synapses on dendritic spines are exceptionally dynamic as compared to other synaptic populations, due to the fact that a large proportion of them disappear and recur again in the same location on a timescale of days. Inhibitory synapses are often found on dendritic spines which receive direct thalamic input. Thus, the function of inhibitory synaptic remodeling at this locale may serve as a mechanism for gating feedforward excitation, rather than, as proposed for excitatory synapses, as a mechanism to remodel circuitry and exchange partners.
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