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Quantitative analysis of synaptic contacts on cortical pyramidal cells

Research Project

Project/Area Number 25290012
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

Kubota Yoshiyuki  生理学研究所, 基盤神経科学研究領域, 准教授 (90192567)

Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2016: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Keywords大脳皮質 / 神経回路 / 錐体細胞 / 非錐体細胞 / 抑制 / 可塑性 / in vivo imaging / シナプス / 棘突起 / 樹状突起 / 電子顕微鏡 / 3次元再構築 / 視床 / 神経科学 / 解剖学 / 共焦点顕微鏡 / 抑制性シナプス / 興奮性シナプス / gephyrin / PSD95 / 動態 / in vivo
Outline of Final Research Achievements

Understanding the brain’s circuit architecture is critical to elucidating its function. We quantitatively analyzed synapse distribution on layer 5 pyramidal cell of rat cortex and found the cell receive totally about 20,000 synapses. About 20 % of them are inhibitory synapse. The inhibitory synapse junction size is varied and correlated with their target size. It probably acts for an efficient inhibition. We found that inhibitory synapses on dendritic spines are exceptionally dynamic as compared to other synaptic populations, due to the fact that a large proportion of them disappear and recur again in the same location on a timescale of days. Inhibitory synapses are often found on dendritic spines which receive direct thalamic input. Thus, the function of inhibitory synaptic remodeling at this locale may serve as a mechanism for gating feedforward excitation, rather than, as proposed for excitatory synapses, as a mechanism to remodel circuitry and exchange partners.

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (66 results)

All 2018 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (5 results) Journal Article (12 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 12 results,  Open Access: 6 results,  Acknowledgement Compliant: 5 results) Presentation (37 results) (of which Int'l Joint Research: 10 results,  Invited: 26 results) Book (4 results) Remarks (8 results)

  • [Int'l Joint Research] Max Planck Institute/Carl Zeiss Microscopy(ドイツ)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] Massachusetts Institute of Technology(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Massachusetts Institute of Technology(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] CRICM-UPMC(フランス)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] Juelich Research institute(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] A carbon nanotube tape for serial-section electron microscopy of brain ultrastructure2018

    • Author(s)
      Kubota Y, Sohn J, Hatada S, Schurr M, StraehleJ, Gour A, Neujahr R, MikiT, Mikula S, Kawaguchi Y
    • Journal Title

      Nat. Commun.

      Volume: 9 Issue: 1 Pages: 437-437

    • DOI

      10.1038/s41467-017-02768-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The diversity of cortical inhibitory synapses.2016

    • Author(s)
      Kubota Y, Karube F, Nomura M, Kawaguchi Y
    • Journal Title

      Front Neural Circuits

      Volume: 10 Pages: 27-27

    • DOI

      10.3389/fncir.2016.00027

    • NAID

      120005980914

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo2016

    • Author(s)
      Villa KL, Berry KP, Subramanian J, Cha JW, Oh CO, Kwon H-B, Kubota Y, So PT, Nedivi, E
    • Journal Title

      Neuron

      Volume: 89 Issue: 4 Pages: 756-769

    • DOI

      10.1016/j.neuron.2016.01.010

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cortical divergent projections in mice originate from two sequentially generated, distinct populations of excitatory cortical neurons with different initial axonal outgrowth characteristics.2015

    • Author(s)
      Hatanaka, Y., Namikawa, T., Yamauchi, K., & Kawaguchi, Y.
    • Journal Title

      Cereb. Cortex

      Volume: - Issue: 5 Pages: 2257-2270

    • DOI

      10.1093/cercor/bhv077

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons2015

    • Author(s)
      Kubota Y, Kondo S, Nomura M, Hatada S, Yamaguchi N, Mohamed AA, Karube F, Luebke J, Kawaguchi Y
    • Journal Title

      eLife

      Volume: 4

    • DOI

      10.7554/elife.07919

    • NAID

      120005997706

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] New developments in electron microscopy for serial image acquisition of neuronal profiles2015

    • Author(s)
      Yoshiyuki Kubota
    • Journal Title

      Microscopy

      Volume: 64 Issue: 1 Pages: 27-36

    • DOI

      10.1093/jmicro/dfu111

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Input integration around the dendritic branches in hippocampal dentate granule cells2014

    • Author(s)
      Kamijo C.T., Hayakawa H., Fukushima Y., Kubota Y., Isomura Y., Tsukada, M., and Aihara T.
    • Journal Title

      Cognitive Neurodynamics

      Volume: Online Issue: 4 Pages: 1-10

    • DOI

      10.1007/s11571-014-9280-6

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Untangling GABAergic wiring in the cortical microcircuit2014

    • Author(s)
      Kubota Y
    • Journal Title

      Current Opinion in Neurobiology

      Volume: 26 Pages: 7-14

    • DOI

      10.1016/j.conb.2013.10.003

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuron Subtypes and Microcircuits in Neocortex2014

    • Author(s)
      窪田 芳之
    • Journal Title

      The Brain & Neural Networks

      Volume: 21 Issue: 3 Pages: 122-131

    • DOI

      10.3902/jnns.21.122

    • NAID

      130004713864

    • ISSN
      1340-766X, 1883-0455
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cortical NO interneurons: from embryogenesis to functions2013

    • Author(s)
      Tricoire L, Kubota Y, Cauli B
    • Journal Title

      Front Neural Circuits

      Volume: 7 Pages: 105-105

    • DOI

      10.3389/fncir.2013.00105

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New insights into the classification and nomenclature of cortical GABAergic interneurons2013

    • Author(s)
      DeFelipe J, Lopez-Cruz PL, Kawaguchi Y, Kisvarday Z, Kubota Y
    • Journal Title

      Nature Reviews Neuroscience

      Volume: 14 Issue: 3 Pages: 202-216

    • DOI

      10.1038/nrn3444

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional Significance of Rall's Power of Three Halves Law in Cortical Nonpyramidal Cells2013

    • Author(s)
      Yoshiyuki Kubota
    • Journal Title

      Advances in Cognitive Neurodynamics (III)

      Volume: XVI Pages: 45-51

    • DOI

      10.1007/978-94-007-4792-0_7

    • ISBN
      9789400747913, 9789400747920
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synapse density and estimated number on various neurons of the rat frontal cortex2017

    • Author(s)
      Kubota Y
    • Organizer
      第94回日本生理学会大会シンポジウム「シナプス分布による神経情報制御の最前線」
    • Place of Presentation
      静岡県浜松市、アクトシティ浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A novel conductive material for ATUMtome tape -Carbon Nanotube-2017

    • Author(s)
      Kubota Y
    • Organizer
      Max Planck/HHMI Connectomics Conference Berlin 2017 シンポジウム
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ATUMtome 用の新開発テープと高解像画像用組織処理法2017

    • Author(s)
      窪田芳之、孫在隣、畑田小百合、川口泰雄
    • Organizer
      第73回日本顕微鏡学会学術集会シンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] A novel tape for ATUMtome and high resolution electron microscopy2017

    • Author(s)
      Kubota Y, Sohn S, Hatada S, Kawaguchi Y
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] The Diversity of Cortical Inhibitory Synapses2017

    • Author(s)
      Kubota Y, Kawaguchi Y
    • Organizer
      The 48th NIPS International Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A conductive novel tape material and a new staining protocol for volume electron microscopy applications2017

    • Author(s)
      Kubota Y, Sohn S, Hatada S, Schurr M, Straehle J, Gour AG, Neujahr R, Mikula S, Kawaguchi Y
    • Organizer
      47th Annual meeting of the Society for Neuroscience
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Conserved dimensions of dendritic trees in cortical pyramidal cell2016

    • Author(s)
      Mohamed AA, Yamaguchi N, Hatada S, Luebke J, Kawaguchi Y, Kubota Y
    • Organizer
      The 7th International Neural Microcircuit Conference -Recent advances in the analysis of cortical microcircuits-
    • Place of Presentation
      愛知県岡崎市、岡崎コンファレンスセンター
    • Year and Date
      2016-12-09
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Diversity of Cortical Inhibitory Synapses.2016

    • Author(s)
      Kubota Y
    • Organizer
      The 7th International Neural Microcircuit Conference - Recent advances in the analysis of cortical microcircuits -
    • Place of Presentation
      愛知県岡崎市、岡崎コンファレンスセンター
    • Year and Date
      2016-12-08
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] GABAergic/non-GABAergic synaptic inputs to striatal medium spiny neurons2016

    • Author(s)
      Kubota Y, Kawaguchi Y
    • Organizer
      46th annual meeting of the Society for Neuroscience
    • Place of Presentation
      米国、San Diego、San Diego Convention Center
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] GABAergic inputs to spine of striatal medium spiny neurons2016

    • Author(s)
      Kubota Y, Kawaguchi Y
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      神奈川県横浜市、パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2016 Annual Research Report
  • [Presentation] An excitatory and inhibitory synapse density on various neurons in the rat frontal cortex2016

    • Author(s)
      Kubota Y, Sekigawa A, Mohamed AA, Kondo S, Karube F, Tanaka Y, Kawaguchi Y,
    • Organizer
      EMBO Dendrites 2016 meeting
    • Place of Presentation
      ギリシャ、クレタ島
    • Year and Date
      2016-06-18
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Structurally authentic model pyramidal and non-pyramidal cells.2016

    • Author(s)
      Kubota Y
    • Organizer
      Digital Representation of Neuronal Morphologies and Tissue: OIST workshop 2016:
    • Place of Presentation
      沖縄県恩納村、OIST
    • Year and Date
      2016-04-11
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ATUMtome/SEMを使った神経組織の3次元再構築解析2016

    • Author(s)
      窪田芳之
    • Organizer
      第122回日本解剖学会総会・全国学術集会 シンポジウム
    • Place of Presentation
      パレット福島(福島県郡山市)
    • Year and Date
      2016-03-30
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経科学における電顕の役割2016

    • Author(s)
      窪田芳之
    • Organizer
      第5回大脳基底核機能研究会
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経科学における電顕の役割2016

    • Author(s)
      窪田芳之
    • Organizer
      第16回日立BIO電顕セミナー(大阪会場)
    • Place of Presentation
      メルパルク大阪(大阪府大阪市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 神経科学における電顕の役割2016

    • Author(s)
      窪田芳之
    • Organizer
      第16回日立BIO電顕セミナー(神奈川会場)
    • Place of Presentation
      神奈川サイエンスパーク(神奈川県川崎市)
    • Year and Date
      2016-03-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 大脳皮質FSバスケット細胞による5層錐体細胞神経支配の様式2015

    • Author(s)
      窪田芳之
    • Organizer
      平成27年度生理研研究会「シナプス・神経ネットワークの機能ダイナミクス」
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2015-12-03
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] An excitatory and inhibitory synapse density on various nonpyramidal cells in the rat cerebral cortex2015

    • Author(s)
      Kubota Y
    • Organizer
      The 2nd East-Asia Microscopy Conference シンポジウム “Connectmics”
    • Place of Presentation
      姫路商工会議所(兵庫県姫路市)
    • Year and Date
      2015-11-25
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons2015

    • Author(s)
      窪田芳之
    • Organizer
      第38回日本神経科学会大会 シンポジウム ”Wiring Inhibitory Synapses and Circuits”
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ATUMtomeを使った脳組織観察法2015

    • Author(s)
      窪田芳之
    • Organizer
      第10回自然科学研究機構技術研究会
    • Place of Presentation
      岡崎コンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2015-06-18
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ATUMtomeおよびSBEMを使った脳組織観察法2015

    • Author(s)
      窪田芳之
    • Organizer
      日本顕微鏡学会「SEM連続断面観察による生物組織三次元再構築法研究部会」第三回研究会
    • Place of Presentation
      山梨県甲州市「ぶどうの丘」
    • Year and Date
      2015-03-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Dynamic behavior of inhibitory synapse on pyramidal cell2015

    • Author(s)
      窪田芳之
    • Organizer
      第120回日本解剖学会総会・全国学術集会、第92回日本生理学会大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 大脳皮質錐体細胞棘突起へ入力する抑制性シナプスの動態2015

    • Author(s)
      窪田芳之
    • Organizer
      自然科学研究機構プロジェクト合同シンポジウム 「脳神経情報の階層的研究」
    • Place of Presentation
      生理学研究所(愛知県岡崎市)
    • Year and Date
      2015-03-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Conserved dimensional properties of dendritic trees in cortical pyramidal cell2014

    • Author(s)
      Y Kubota, AA Mohamed, N Yamaguchi, S Hatada, J Luebke, Y Kawaguchi
    • Organizer
      44th annual meeting of the Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大脳皮質錐体細胞の樹状突起の形態解析2014

    • Author(s)
      窪田芳之、AA Mohamed、根東覚、野村真樹、川口泰雄
    • Organizer
      第10回IIRSセミナー
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2014-11-07
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cortical fast spiking basket cell inhibition on pyramidal cells through multiple modalities and innervation styles2014

    • Author(s)
      Kubota Y
    • Organizer
      4th Joint CIN-NIPS Symposium University of Tuebingen
    • Place of Presentation
      Univ. Tuebingen、ドイツ
    • Year and Date
      2014-10-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Conserved dimensional properties of dendritic trees in cortical pyramidal cell2014

    • Author(s)
      AA Mohamed, N Yamaguchi, S Hatada, J Luebke, Y Kawaguchi, Y Kubota
    • Organizer
      第37回 日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] TEM, FIB/SEM, DiK-SEMを使った神経組織の電子顕微鏡連続切片作製2014

    • Author(s)
      窪田芳之
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学、鹿児島市、鹿児島県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] TEM, FIB/SEM, DiK-SEMを使った神経組織の電子顕微鏡連続切片作製2014

    • Author(s)
      窪田芳之
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学、小山市、栃木県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Locally limited conductance of IPSC elicited by fast spiking interneurons synapsing onto cortical pyramidal cell2013

    • Author(s)
      窪田芳之
    • Organizer
      第36回日本神経科学会大会
    • Place of Presentation
      京都国際会館、京都市、京都府
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 大脳皮質非錐体細胞の樹状突起の形態解析2013

    • Author(s)
      窪田芳之
    • Organizer
      第54回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      航空会館、東京、東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Locally limited conductance of IPSC elicited by fast spiking interneurons synapsing onto cortical pyramidal cell2013

    • Author(s)
      窪田芳之
    • Organizer
      第6回国際神経回路会議 - Functional Mechanism of Cortical Microcircuit
    • Place of Presentation
      岡崎コンファレンスセンター、岡崎市、愛知県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Locally limited conductance of IPSCs elicited by cortical fast spiking basket cell2013

    • Author(s)
      Yoshiyuki Kubota, Satoru Kondo, Masaki Nomura and Yasuo Kawaguchi
    • Organizer
      Cell Symposia "The Networked Brain"
    • Place of Presentation
      San Diego Hilton, San Diego, U.S.A.
    • Related Report
      2013 Annual Research Report
  • [Presentation] Differences in size of cortical synapses underly distinct modes of inhibitory control2013

    • Author(s)
      Kubota Y, Kondo S, Nomura M, Karube F, Luebke J and Kawaguchi Y
    • Organizer
      43rd annual meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego convention center, San Diego, U.S.A.
    • Related Report
      2013 Annual Research Report
  • [Presentation] 電子顕微鏡連続切片の再構成による大脳皮質抑制性神経細胞の特徴抽出

    • Author(s)
      窪田芳之
    • Organizer
      IIRSセミナー
    • Place of Presentation
      東京大学、東京、東京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 樹状突起分岐部の微小管のFIB/SEMによる観察

    • Author(s)
      窪田芳之
    • Organizer
      日本顕微鏡学会「様々な極微イメージング技術研究部会」第1回研究会
    • Place of Presentation
      久留米大学、久留米市、福岡県
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 大脳皮質FSバスケット細胞から錐体細胞への 抑制性シナプス結合特性

    • Author(s)
      窪田芳之
    • Organizer
      Frotier BioScience Colloquium
    • Place of Presentation
      大阪大学生命機能研究科、吹田市、大阪府
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] ライフサイエンス顕微鏡学ハンドブック/各種電子顕微鏡による連続画像撮影2018

    • Author(s)
      山科正平、高田邦昭責任編集、窪田芳之 他著
    • Total Pages
      344
    • Publisher
      朝倉書店
    • ISBN
      9784254310948
    • Related Report
      2017 Annual Research Report
  • [Book] Neuromethods Vol 110, Receptor and ion channel detection in the brain2016

    • Author(s)
      Kubota Y (Lujan R, Ciruela F, eds)
    • Total Pages
      475
    • Publisher
      Springer
    • Related Report
      2016 Annual Research Report
  • [Book] Morphological and neurochemical characterization of electrophysiologically identified cells in "Receptor and Ion Channel Detection in the Brain: methods and protocols"2016

    • Author(s)
      Kubota Y
    • Total Pages
      277
    • Publisher
      Springer, New York
    • Related Report
      2015 Annual Research Report
  • [Book] 3次元構築と立体画像(岡部繁男編集) ライフサイエンス顕微鏡学ハンドブック2014

    • Author(s)
      窪田芳之
    • Total Pages
      299
    • Publisher
      朝倉書店
    • Related Report
      2013 Annual Research Report
  • [Remarks] カーボンナノチューブで電子顕微鏡神経回路観察法に革命! -マウス全脳の神経回路構造解明へ一歩前進-

    • URL

      http://www.nips.ac.jp/release/2018/02/post_358.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 大脳皮質の神経細胞棘突起の同じところに出現消失を繰り返す抑制性シナプス

    • URL

      http://www.nips.ac.jp/nips_research/2016/04/_in_vivo_imaging1in_vivo2_162349cranial_window10in_vivo_imaging23.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] 大脳皮質の錐体細胞に分布する抑制性シナプスの形態と機能

    • URL

      http://www.nips.ac.jp/release/2015/07/post_299.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 大脳皮質FSバスケット細胞の5層の錐体細胞への抑制性神経支配様式

    • URL

      http://www.fmu.ac.jp/acs/research/page/2

    • Related Report
      2015 Annual Research Report
  • [Remarks] 大脳皮質の神経細胞棘突起の同じところに出現消失を繰り返す抑制性シナプス

    • URL

      https://www.nips.ac.jp/nips_research/2016/04/_in_vivo_imaging1in_vivo2_162349cranial_window10in_vivo_imaging23.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] Inhibitory synapses are repeatedly assembled

    • URL

      https://www.nips.ac.jp/nips_research/eng/2016/04/_in_vivo_imaging1in_vivo2_162349cranial_window10in_vivo_imaging23.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] Functional effects of distinct innervation styles

    • URL

      https://www.nips.ac.jp/nips_research/eng/2015/07/post_299.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 生理学研究所大脳神経回路論研究部門ホームページ

    • URL

      http://www.nips.ac.jp/circuit/

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-16  

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