| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2016: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2015: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Outline of Final Research Achievements |
Serotonin 2C (5-HT2C) receptor is expressed in the nervous system and involved in the emotion, stress and addiction. It is also known to undergo mRNA editing by adenosine deaminase acting on RNA type1 (ADAR1) and ADAR2 and make up to 24 isoforms and show the variety of epigenetic modification. During the period of receiving grants, we revealed that RNA editing of 5-HT2C receptor determines the alcohol preference in mice after chronic alcohol exposure using genetically modified mice. We also clarified that mice exclusively expressing non-edited type of 5-HT2C receptor isoform (INI type) showed desperate behavior and NPY neurons in the nucleus accumbens in the forebrain are involved in that behavior. Thus, we demonstrated that RNA editing of 5-HT2C receptor is related to alcohol preference and emotional behavior.
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