The molecular action of Abeta oligomer on Alzheimer's disease.
| Project/Area Number |
25290018
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Osaka City University |
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Principal Investigator |
MORI HIROSHI 大阪市立大学, 大学院医学研究科, 特任教授 (10159189)
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| Co-Investigator(Kenkyū-buntansha) |
Tomiyama Takami 大阪市立大学, 大学院医学研究科, 准教授 (10305633)
Umeda Tomohiro 大阪市立大学, 大学院医学研究科, 助教 (70549790)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 脳神経疾患 / 痴呆 / 老化 / アミロイド / オリゴマー |
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| Outline of Final Research Achievements |
We examined the most promising Abeta oligomer hypothesis for therapeutic drug development of Alzheimer's disease. By additional introduction of human tau into an Abeta-oligomer mouse, we succeeded in making a new model to mimic Alzheimer's disease. Furthermore, we found an improvement effect with ability for space recognition or other pathological changes to rifampicin by the drug dosage experiment using the model. Hence, we believe that the Abeta oligomer is certificated with the new model, which are supposed to be suitable for future drug screening.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Proteomic analysis of the hippocampus in Alzheimer's disease model mice by using two-dimensional fluorescence difference in gel electrophoresis2013
Author(s)
Takano M., Yamashita T., Nagano K., Otani M., Maekura K., Kamada H., Tsunoda S., Tsutsumi Y., Tomiyama T., Mori H., Matsuura K., Matsuyama S
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Journal Title
Neuroscience Letters
Volume: 534
Pages: 85-9
DOI
Related Report
Peer Reviewed
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[Journal Article] A drug screening platform for Alzheimer's disease with intracellular Aβ oligomers using patient-specific iPSCs2013
Author(s)
Kondo, T., (他24名), Murakami, K., Irie, K., Klein, W. L., Mori, H., Asada, T., Takahashi, R., Iwata, N., Yamanaka, S., Inoue, H
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Journal Title
Cell Stem Cell
Volume: 12
Issue: 4
Pages: 487-496
DOI
Related Report
Peer Reviewed / Open Access
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