| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Cdk5 is a brain specific membrane-bound protein kinase. We have analyzed a role of Cdk5 in neurite outgrowth in mouse primary neurons. Cdk5 phosphorylates LMTK1, a novel Ser/Thr kinase in brains, and GRAB, an activator of Rab8. Phosphorylated LMTK1 suppressed activation of Rab11 and phosphorylated GRAB lost the Rab9 activation activity. Rab11 and Rab8 are major regulators in endosome transport, supplying membrane components to the tip of axon or dendrites. Thus, their inactivation results in the reduced neurite outgrowth. This signaling cascade is negative regulatory mechanism of neurite outgrowth.
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