| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Under long culture, superior cervical ganglion neurons taken from 7th day rats form strong synapses. Using this model synapse, presynaptic proteins which regulate construction, maintenance and strengthen cholinergic synapses, temporal and special activation and inactivation of functioning synapse that underlie synaptic plasticity were studied with genetic and philological approaches. Results revealed the candidates of the factors, dynamics of Ca2+ concentration after action potential(s) firing, Ca2+-binding proteins that activate cascades of presynaptic functional proteins, and proteins that control Ca2+channel mobility and activity. In the mature synapse, milliseconds Ca2+ dynamics activate multiple protein cascades for synaptic vesicle control and synaptic plasticity.
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