| Project/Area Number |
25290027
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Wada Keiji 国立研究開発法人国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 部長 (70250222)
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| Co-Investigator(Renkei-kenkyūsha) |
SEKIGUCHI Masayuki 国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 (80260339)
KABUTA Tomohiro 国立精神・神経医療研究センター, 神経研究所疾病研究第四部, 室長 (70535765)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 脂質 / 高脂肪食 / マウス / オートファジー / 酸化ストレス / 生活習慣 / 母体 / ユビキチン / スパイン / 脳機能発達 / LAMP2 / 脂肪酸 / 核酸 / 不安 / 情動 |
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| Outline of Final Research Achievements |
We aimed to elucidate the relationship between lipid metabolism and brain function in the mouse. To achieve the goal, we focus on LAMP-2 protein, a member of the autophagy system, and UCH-L1, a deubiquitinating enzyme in the ubiquitin system. We also studied the effect of diet on the mouse brain function.
We observed that the LAMP-2 system was involved in various metabolism including nucleic acids, and that a mouse strain without UCH-L1 expression showed a delay of dendritic spine maturation in brain cortex. We also observed that maternal high fat intake at the lactation period resulted in the suppression of dendritic spine maturation.
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