| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
Neurons have the intrinsic capacity to produce insulin, similar to pancreatic cells. Adult neurogenesis in the hippocampus (HPC) is significantly decreased in diabetic patients. As a result, learning and memory functions decrease. In the study, we compared the effect of diabetes on neurogenesis and insulin expression in adult NSCs. Adult NSCs were derived from the HPC or OB of STZ-induced diabetic rats.Diabetes progression influenced important genes that were required for insulin expression. By using identified diabetes-response genes, OB NSCs from diabetes patients can be used to monitor processes during diabetes progression that cause neurodegeneration in the CNS. Since HPC NSCs and OB NSCs exhibited similar gene expression profiles during diabetes progression, OB NSCs, which are more easily collected and established than HPC NSCs, may potentially be used for screening of effective drugs for neurodegenerative disorders that cause malignant damage to CNS functions.
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