Analysis of signaling pathways for liver cancer stem cell maintenance
| Project/Area Number |
25290045
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Yokohama City University |
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Principal Investigator |
MAEDA Shin 横浜市立大学, 医学(系)研究科(研究院), 教授 (40415956)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院, 助教 (90518945)
SHIBATA Wataru 横浜市立大学, 先端医科学研究センター, 准教授 (00435819)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | 肝臓癌 / 肝癌 / 幹細胞 / 脂肪肝 / 肝臓がん |
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| Outline of Final Research Achievements |
About 35,000 people every year have died of liver cancer in our country, and treatment for the advanced cancer has not been established yet.
Treatment for the differentiated cancer cells is not enough and it's necessary to understand a peculiar character of a stem cell as the cause of the treatment resistance and the recurrence. In this study, we have made a liver cancer mouse model, established a cell line by a liver cancer 3D culture and analyzed a relationship between epithelial-mesenchymal transition and cancer stemness.
These findings may provide the fundamental materials and technique for development of therapies for cancer stem cells.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.2016
Author(s)
Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y.
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Journal Title
Sci Rep
Volume: 6
Issue: 2
Pages: 23899-23899
DOI
Related Report
Peer Reviewed
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[Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion.2016
Author(s)
Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y
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Journal Title
Sci Rep
Volume: 印刷中
Issue: 1
Pages: 23899-23899
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress.2015
Author(s)
Sakitani K, Hirata Y, Hikiba Y, Hayakawa Y, Ihara S, Suzuki H, Suzuki N, Serizawa T, Kinoshita H, Sakamoto K, Nakagawa H, Tateishi K, Maeda S, Ikenoue T, Kawazu S, Koike K.
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Journal Title
BMC Cancer
Volume: １５
Issue: 1
Pages: 795-808
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis.2014
Author(s)
Nakagawa H, Hikiba Y, Hirata Y, Font-Burgada J, Sakamoto K, Hayakawa Y, Taniguchi K, Umemura A, Kinoshita H, Sakitani K, Nishikawa Y, Hirano K, Ikenoue T, Ijichi H, Dhar D, Shibata W, Akanuma M, Koike K, Karin M, Maeda S.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 111
Issue: 3
Pages: 1090-1095
DOI
Related Report
Peer Reviewed
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