| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Outline of Final Research Achievements |
Plastic epigenetic regulation might be linked to the morphological and lineage heterogeneity. However, knowledge about how epigenome is altered specifically at certain loci and how this affects the phenotypes of tumor is largely unknown. In the current project, we found that the notch-regulated long non-coding RNA, TUG1, promotes self-renewal by quenching microRNA in the cytoplasm and recruiting polycomb to repress differentiation genes in the nucleus. Intravenous treatment with antisense oligonucleotides targeting TUG1 coupled with drug delivery system induces glioma cell differentiation and efficiently represses glioma cell growth in vivo. Our data provide a strong rationale for targeting TUG1 as a specific and potent therapeutic approach to eliminate the glioma cells.
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