Study of regulatory mechanism controlling cancer cell reprogramming

• Project/Area Number: 25290048
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Nagoya City University (2014-2016); 愛知県がんセンター(研究所) (2013)
• Principal Investigator: KONDO Yutaka 名古屋市立大学, 医学(系)研究科(研究院), 教授 (00419897)
• Co-Investigator(Renkei-kenkyūsha): Natsume Atsushi 名古屋大学, 医学系研究科, 准教授 (30362255) ; Shinjo Keiko 名古屋市立大学, 大学院医学研究科, 助教 (40641618) ; Katsushima Keisuke 名古屋市立大学, 大学院医学研究科, 助教 (00754053)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: エピジェネティクス / 非翻訳RNA / がん / がん治療 / エピゲノム / 膠芽腫 / ドラッグデリバリーシステム / 脳腫瘍 / がん幹細胞 / 1エピゲノム

Outline of Final Research Achievements

Plastic epigenetic regulation might be linked to the morphological and lineage heterogeneity. However, knowledge about how epigenome is altered specifically at certain loci and how this affects the phenotypes of tumor is largely unknown. In the current project, we found that the notch-regulated long non-coding RNA, TUG1, promotes self-renewal by quenching microRNA in the cytoplasm and recruiting polycomb to repress differentiation genes in the nucleus. Intravenous treatment with antisense oligonucleotides targeting TUG1 coupled with drug delivery system induces glioma cell differentiation and efficiently represses glioma cell growth in vivo. Our data provide a strong rationale for targeting TUG1 as a specific and potent therapeutic approach to eliminate the glioma cells.

Research Products

• [Journal Article] Histone deacetylase inhibition in prostate cancer triggers miR-320-mediated suppression of the androgen receptor. (2016)
  • Author(s): Sato S, Katsushima K, Shinjo K, Hatanaka A, Ohka F, Suzuki S, Naiki-Ito A, Soga N, Takahashi S, Kondo Y.
  • Journal Title: Cancer Res. Volume: 76 Issue: 14 Pages: 4192-204
  • DOI: 10.1158/0008-5472.can-15-3339
  • Peer Reviewed / Open Access
• [Journal Article] LATS2 Positively Regulates Polycomb Repressive Complex 2. (2016)
  • Author(s): Torigata K, Daisuke O, Mukai S, Hatanaka A, Ohka F, Motooka D, Nakamura S,Ohkawa Y, Yabuta N, Kondo Y, Nojima H.
  • Journal Title: PLoS One Volume: 11 Issue: 7 Pages: e0158562-e0158562
  • DOI: 10.1371/journal.pone.0158562
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Epigenetic upregulation of Arl4c expression, due to DNA hypomethylation in the 3'-untranslated region, promotes tumorigenesis in lung squamous cell carcinoma. (2016)
  • Author(s): Fujii, S., Shinjo, K., Matsumoto, S., Harada, T., Nojima, S., Sato, S., Usami, Y., Toyosawa, S., Morii, E., Kondo, Y., and Kikuchi, A
  • Journal Title: Oncotarget Volume: ７ Issue: 49 Pages: 81571-81587
  • DOI: 10.18632/oncotarget.13147
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells. (2016)
  • Author(s): Murakami-Tonami Y, Ikeda H, Yamagishi R, Inayoshi M, Inagaki S, Kishida S, Komata Y, Jan Koster, Takeuchi I, Kondo Y, Maeda T, Sekido Y, Murakami H, Kadomatsu K.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 31615-31615
  • DOI: 10.1038/srep31615
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment. (2016)
  • Author(s): Katsushima K, Natsume A, Ohka F, Shinjo K, Hatanaka A, Ichimura N, Sato S, Takahashi S, Kimura H, Totoki Y, Shibata T, Naito M, Kim HJ, Miyata K, Kataoka K, Kondo Y.
  • Journal Title: Nat Commun. Volume: 7 Issue: 1 Pages: 13616-13616
  • DOI: 10.1038/ncomms13616
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Augmenting effects of gestational arsenite exposure of C3H mice on the hepatic tumors of the F2 male offspring via the F1 male offspring (2015)
  • Author(s): Nohara K, Okamura K, Suzuki T, Murai H, Ito T, Shinjo K, Takumi S, Michikawa T, Kondo Y, Hata K.
  • Journal Title: J Appl Toxicol Volume: 印刷中 Issue: 1 Pages: 105-112
  • DOI: 10.1002/jat.3149
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer. (2015)
  • Author(s): 5.Ichimura N, Shinjo K, An B, Shimizu Y, Yamao K, Ohka F, Katsushima K, Hatanaka A, Tojo M, Yamamoto E, Suzuki H, Ueda M, Kondo Y
  • Journal Title: Cancer Prev Res (Phila) Volume: 10 Issue: 8 Pages: 702-11
  • DOI: 10.1158/1940-6207.capr-14-0306
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mutational landscape and clonal architecture in grade II and III gliomas (2015)
  • Author(s): Suzuki H, Aoki K, Natsume A, Ogawa S. et al.
  • Journal Title: Nat Genet. Volume: 47 Issue: 5 Pages: 458-468
  • DOI: 10.1038/ng.3273
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Regulation of AURKC expression by CpG island methylation in human cancer cells. (2015)
  • Author(s): Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estecio MR, Hamilton SR, Wistuba I, Issa JP, Sen S.
  • Journal Title: Tumour Biol Volume: 36 Issue: 10 Pages: 8147-58
  • DOI: 10.1007/s13277-015-3553-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Targeting cancer epigenetics: Linking basic biology to clinical medicine. (2015)
  • Author(s): Shinjo K, Kondo Y.
  • Journal Title: Adv Drug Deliv Rev Volume: 95 Pages: 56-64
  • DOI: 10.1016/j.addr.2015.10.006
  • Peer Reviewed
• [Journal Article] Long-Term Pancreatic Beta Cell Exposure to High Levels of Glucose but Not Palmitate Induces DNA Methylation within the Insulin Gene Promoter and Represses Transcriptional Activity. (2015)
  • Author(s): Ishikawa K, Tsunekawa S, Ikeniwa M, Izumoto T, Iida A, Ogata H, Uenishi E, Seino Y, Ozaki N, Sugimura Y, Hamada Y, Kuroda A, Shinjo K, Kondo Y, Oiso Y.
  • Journal Title: PLoS One Volume: 10(2) Issue: 2 Pages: e0115350-e0115350
  • DOI: 10.1371/journal.pone.0115350
  • NAID: 120006872353
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] miR-615-5p is epigenetically inactivated and functions as a tumor suppressor in pancreatic ductal adenocarcinoma. (2015)
  • Author(s): Gao W, Gu Y, Li Z, Cai H, Peng Q, Tu M, Kondo Y, Shinjo K, Zhu Y, Zhang J, Sekido Y, Han B, Qian Z, Miao Y.
  • Journal Title: Oncogene Volume: 34 Issue: 13 Pages: 1629-40
  • DOI: 10.1038/onc.2014.101
  • Peer Reviewed
• [Journal Article] Non-coding RNAs as epigenetic regulator of glioma stem-like cell differentiation. (2014)
  • Author(s): Katsushima K, Kondo Y.
  • Journal Title: Front Genet Volume: 5 Pages: 1-8
  • DOI: 10.3389/fgene.2014.00014
  • Peer Reviewed
• [Journal Article] Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators (2014)
  • Author(s): Tahara T, Yamamoto E, Madireddi P, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, Kondo Y, Toyota M, Issa JP, Estecio MR
  • Journal Title: Gastroenterology Volume: 146 Issue: 5 Pages: 530-538
  • DOI: 10.1158/0008-5472.can-13-1865
  • Peer Reviewed
• [Journal Article] Shall we crosstalk? - The relationship between DNA methylation and histone H3 lysine 27 trimethylation. (2014)
  • Author(s): Kondo Y
  • Journal Title: Bioessays Volume: 36 Issue: 2 Pages: 128-128
  • DOI: 10.1002/bies.201300164
  • Peer Reviewed
• [Journal Article] Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators. (2014)
  • Author(s): Tahara T, Yamamoto E, Madireddi P, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, Kondo Y, Toyota M, Issa JP, Estécio MR.
  • Journal Title: Gastroenterology Volume: 146 Issue: 2 Pages: 530-8
  • DOI: 10.1053/j.gastro.2013.10.060
  • Peer Reviewed
• [Journal Article] Hepatitis virus infection affects DNA methylation in mice with humanized livers. (2014)
  • Author(s): Okamoto Y, Shinjo K, et al.
  • Journal Title: Gastroenterology Volume: 146 Issue: 2 Pages: 562-572
  • DOI: 10.1053/j.gastro.2013.10.056
  • Peer Reviewed / Open Access
• [Journal Article] RASSF3 downregulation increases malignant phenotypes of non-small cell lung cancer. (2013)
  • Author(s): Fukatsu A, Ishiguro F, et al.
  • Journal Title: Lung Cancer Volume: 83 Issue: 1 Pages: 23-29
  • DOI: 10.1016/j.lungcan.2013.10.014
  • Peer Reviewed
• [Journal Article] Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. (2013)
  • Author(s): Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y.
  • Journal Title: Cancer Res. Volume: 15 Issue: 14 Pages: 4559-4570
  • DOI: 10.1158/0008-5472.can-13-0109
  • Peer Reviewed
• [Journal Article] Membranous expression of activated leukocyte cell adhesion molecule contributes to poor prognosis and malignant phenotypes of non-small-cell lung cancer. (2013)
  • Author(s): Futoshi Ishiguro
  • Journal Title: J Surg Res. Volume: 179 Issue: 1 Pages: 24-32
  • DOI: 10.1016/j.jss.2012.08.044
  • Peer Reviewed
• [Presentation] 非翻訳RNAを標的とした新規エピゲノム治療法の開発 (2016)
  • Author(s): 近藤 豊
  • Organizer: 日本環境変異原学会第 45回大会
  • Place of Presentation: つくば国際会議場 (茨城県つくば市)
  • Year and Date: 2016-11-17
• [Presentation] Targeting long non-coding RNA as a new cancer treatment. (2016)
  • Author(s): Kondo Y.
  • Organizer: Seminar at Fudan University.
  • Place of Presentation: Fudan University (上海, 中国）
  • Year and Date: 2016-11-04
  • Int'l Joint Research / Invited
• [Presentation] Epigenetic Regulation by Notch Signaling in Glioma. (2016)
  • Author(s): Kondo Y.
  • Organizer: 12th International Conference on Protein Phosphatase & International Symposium on Innovative Research for Genome-Based Drug Discovery and Cancer Therapeutics.
  • Place of Presentation: 近畿大学 東大阪キャンパス (大阪府東大阪市)
  • Year and Date: 2016-10-29
  • Int'l Joint Research / Invited
• [Presentation] Notchシグナルにより誘導される長鎖非翻訳RNA TUG1を標的としたグリオーマ治療薬の開発に関する研究 (2016)
  • Author(s): 勝島啓佑、夏目敦至、大岡史治、新城恵子、市村典久、畑中彬良、柴田龍弘、宮田完二郎、片岡一則、近藤 豊
  • Organizer: 第75回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川件横浜市)
  • Year and Date: 2016-10-07
• [Presentation] 非翻訳RNAを標的とした新規がん治療法の開発 (2016)
  • Author(s): 近藤 豊
  • Organizer: 第75回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜 (神奈川件横浜市)
  • Year and Date: 2016-10-06
• [Presentation] Targeting Long Non-coding RNA as an Effective Treatment for Glioma. (2016)
  • Author(s): 近藤 豊
  • Organizer: 第89回 日本生化学会大会
  • Place of Presentation: 仙台国際センター (宮城県仙台市)
  • Year and Date: 2016-09-27
• [Presentation] 膠芽腫に対する新規エピゲノム治療法の開発. (2016)
  • Author(s): 近藤 豊
  • Organizer: 第20回 日本がん分子標的治療学会
  • Place of Presentation: 別府国際コンベンションセンター B-CON PLAZA (大分県別府市)
  • Year and Date: 2016-06-01
• [Presentation] Inhibition of histone deacetylase induces miRNA-mediated androgen receptor suppression in prostate cancer. (2016)
  • Author(s): Sato S, Takahashi S, Kondo Y.
  • Organizer: KSBMB International Conference 2016.
  • Place of Presentation: COEX (Seoul, Korea)
  • Year and Date: 2016-05-20
  • Int'l Joint Research
• [Presentation] Inhibition of histone deacetylase induces miR-320-mediated androgen receptor suppression in prostate cancer. (2016)
  • Author(s): Sato S, Katsushima K, Shinjo K, Takahashi S, Kondo Y.
  • Organizer: AACR 107th Annual Meeting
  • Place of Presentation: Ernest N. Morial Convention Center (New Orleans, USA)
  • Year and Date: 2016-04-18
  • Int'l Joint Research
• [Presentation] がんのエピゲノム研究から新しい治療法の開発へ (2016)
  • Author(s): 近藤 豊
  • Organizer: 第13回日本免疫治療学研究会学術集会
  • Place of Presentation: 東京ガーデンパレス（東京都、文京区）
  • Year and Date: 2016-02-27
  • Invited
• [Presentation] Clinical implications of epigenetic alterations in human tumors (2015)
  • Author(s): Kondo Y.
  • Organizer: The 20th Japanese Foundation for Cancer Research
  • Place of Presentation: Miraikan（東京都、江東区）
  • Year and Date: 2015-12-10
  • Invited
• [Presentation] がんのエピゲノム解読による新たながん治療開発 (2015)
  • Author(s): 近藤 豊
  • Organizer: 第53回日本癌治療学会学術集会
  • Place of Presentation: 国立京都国際会館（京都府、京都市）
  • Year and Date: 2015-10-29
  • Invited
• [Presentation] グリオーマの発がんに関わるエピゲノム異常 (2015)
  • Author(s): 近藤 豊
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2015-10-08
  • Invited
• [Presentation] Interaction between Microenvironment and Epigenome in Gliomagenesis (2015)
  • Author(s): 近藤 豊
  • Organizer: The 40th Naito Conference on Epigenetics - From Histone Code to Therapeutic Strategy
  • Place of Presentation: シャトレーゼガトーキングダムサッポロ（北海道、札幌市）
  • Year and Date: 2015-09-17
  • Invited
• [Presentation] TUG1, a Notch-regulated Non-coding RNA Maintains Stemness in Gliomas. (2015)
  • Author(s): Kondo Y.
  • Organizer: The 10th Asian Epigenomics Meeting
  • Place of Presentation: KOFST(Seoul, Korea)
  • Year and Date: 2015-09-09
  • Int'l Joint Research
• [Presentation] Interaction between Microenvironment and Epigenetics in Glioma. (2015)
  • Author(s): Kondo Y.
  • Organizer: The 34th Sapporo International Cancer Symposium
  • Place of Presentation: ロイトン札幌ホテル（北海道、札幌市）
  • Year and Date: 2015-06-15
  • Int'l Joint Research / Invited
• [Presentation] がんエピゲノム異常を標的とした治療・診断法の開発 (2015)
  • Author(s): 近藤 豊
  • Organizer: 第3回 国際先端生物学・医学・工学会議
  • Place of Presentation: 名古屋大学豊田講堂シンポジオン（愛知県名古屋市）
  • Year and Date: 2015-01-16
  • Invited
• [Presentation] A study of novel DNA methylation biomarkers and assays to detect circulating tumor DNA. (2014)
  • Author(s): Kondo Y.
  • Organizer: The 19th Japan-Korea Cancer Research Workshop
  • Place of Presentation: Hyatt Regency Jeju (Jeju, Korea)
  • Year and Date: 2014-11-29
  • Invited
• [Presentation] 細胞外環境による脳腫瘍幹細胞のエピジェネティック制御 (2014)
  • Author(s): 近藤 豊
  • Organizer: 第73回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-25
• [Presentation] Long Noｎ-coding RNA Regulation of the Epigenome in Glioblastoma. (2014)
  • Author(s): Kondo Y.
  • Organizer: EPIGENETICS IN DEVELOPMENT & DISEASES 9TH ASIAN EPIGENOMICS MEETING
  • Place of Presentation: Matrix (Biopolis, Singapore)
  • Year and Date: 2014-08-25
  • Invited
• [Presentation] エピジェネティクスによるがん細胞の動的・特異的制御 (2014)
  • Author(s): 近藤 豊
  • Organizer: 第2回 Aging, Bone and Cancer Frontline Forum
  • Place of Presentation: 山の上ホテル（東京都千代田区）
  • Year and Date: 2014-05-08
  • Invited
• [Presentation] Glioma stem cells maintained by notch-epigenetic pathway. (2014)
  • Author(s): Kondo Y.
  • Organizer: 2014 SNUCRI Cancer Symposium
  • Place of Presentation: Hotel Hyundai in Mokpo (Mokpo, Korea)
  • Year and Date: 2014-04-17
  • Invited
• [Presentation] New technology to detect DNA methylation in plasma sample from lung cancer patients. (2014)
  • Author(s): Kondo Y.
  • Organizer: American Association for Cancer Research ANNUAL MEETING 2014
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
  • Year and Date: 2014-04-06
• [Presentation] エピゲノム情報を利用した新しいがんの予防・診断・治療
  • Author(s): 近藤 豊
  • Organizer: 第40回 日本毒性学会学術年会
  • Place of Presentation: 幕張メッセ 国際会議場（千葉県）
  • Invited
• [Presentation] がん細胞を制御するエピゲノム機構の解明と治療への展望
  • Author(s): 近藤 豊
  • Organizer: 第22回 日本がん転移学会学術集会・総会
  • Place of Presentation: ホテル ブエナビスタ（長野県）
  • Invited
• [Presentation] Epigenetic Plasticity Regulated by Polycomb Repressive Complex 2 in Human Glioblastoma
  • Author(s): 近藤 豊
  • Organizer: Gordon Research Conference - Cancer Genetics & Epigenetics
  • Place of Presentation: Lucca, Italy
• [Book] 次世代がん治療研究最前線 (DNAメチル化によるがん診断) (2017)
  • Author(s): 間瀬聖子、近藤 豊
  • Total Pages: 7
  • Publisher: 株式会社 エヌ・ティー・エス
• [Book] 日本薬理学雑誌 (膠芽腫における長鎖非翻訳RNAとエピゲノム制御異常) (2016)
  • Author(s): 出口彰一、近藤 豊
  • Total Pages: 5
  • Publisher: 公益財団法人 日本薬理学会
• [Book] 血液内科 (がんのエピゲノム解読と新薬開発) (2016)
  • Author(s): 戸谷治仁、近藤 豊
  • Total Pages: 9
  • Publisher: 科学評論社
• [Book] Clinical Significance of Epigenetic Alterations in Glioblastoma. (2015)
  • Author(s): Ohka F, Natume A, Kondo Y.
  • Total Pages: 12
  • Publisher: Academic Press
• [Book] Frontiers in Gastroenterology (2015)
  • Author(s): 新城恵子、近藤 豊
  • Total Pages: 8
  • Publisher: 株式会社 メディカルレビュー社
• [Book] Cancer Science (2014)
  • Author(s): Kondo Y, Katsushima K, Ohka F, Natsume A, Shinjo K.
  • Total Pages: 7
  • Publisher: The official journal of the Japanese Cancer Association
• [Book] エピジェネティクスの産業応用 (2014)
  • Author(s): 勝島啓佑、近藤 豊
  • Total Pages: 9
  • Publisher: 株式会社 シーエムシー出版
• [Book] 医学のあゆみ がんゲノム研究の進歩－網羅的解析からの知見 (2014)
  • Author(s): 大岡史治、近藤 豊
  • Total Pages: 6
  • Publisher: 医歯薬出版 株式会社
• [Book] 実験医学増刊 個別化医療を拓くがんゲノム研究 解き明かされるがんの本質と分子診断・治療応用への展開 (2014)
  • Author(s): 近藤 豊
  • Total Pages: 7
  • Publisher: 株式会社 羊土社
• [Book] NEUROLOGICAL SURGERY 脳神経外科 (2014)
  • Author(s): 出口彰一、近藤 豊、夏目敦至
  • Total Pages: 9
  • Publisher: 株式会社 医学書院
• [Book] THE JOURNAL OF BIOCHEMISTRY (2014)
  • Author(s): Kondo Y.
  • Total Pages: 9
  • Publisher: OXFORD JOURNALS
• [Book] 実験医学 特集 原因か？結果か？がんのエピゲノム異常 環境因子による発がんメカニズムの理解からエピゲノム創薬へ (2014)
  • Author(s): 市村典久、近藤 豊
  • Total Pages: 7
  • Publisher: 株式会社 羊土社
• [Book] 遺伝子医学 MOOK エピジェネティクスと病気 (2013)
  • Author(s): 大岡史治 近藤 豊
  • Total Pages: 6
  • Publisher: 株式会社 メディカルドゥ
• [Book] がん基盤生物学 ‐革新的シーズ育成に向けて‐ (2013)
  • Author(s): 近藤 豊
  • Total Pages: 11
  • Publisher: 株式会社 南山堂
• [Book] イラストで徹底理解するエピジェネティクスキーワード事典 (2013)
  • Author(s): 近藤 豊 新城恵子
  • Total Pages: 10
  • Publisher: 株式会社 羊土社
• [Patent(Industrial Property Rights)] 抗腫瘍性ドラッグデリバリー製剤 (2015)
  • Inventor(s): 近藤豊、勝島啓佑、片岡一則、宮田完二郎
  • Industrial Property Rights Holder: 近藤豊、勝島啓佑、片岡一則、宮田完二郎
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-226895
  • Filing Date: 2015-11-19
• [Patent(Industrial Property Rights)] 肺癌の検査方法 (2014)
  • Inventor(s): 近藤 豊、新城恵子
  • Industrial Property Rights Holder: 近藤 豊、新城恵子
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-055322
  • Filing Date: 2014-03-18