Analysis of cell-context dependent features of adhesion molecules for cancer diagnosis
Project/Area Number |
25290051
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Tumor diagnostics
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
松原 大祐 自治医科大学, 医学部, 准教授 (80415554)
後藤 明輝 秋田大学, 医学(系)研究科(研究院), 教授 (90317090)
櫻井 美佳 東京大学, 医科学研究所, 助教 (80508359)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2015: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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Keywords | 分子標的薬 / 薬剤耐性 / 肺線がん / EGFR-TKI / 細胞接着 / がん抑制遺伝子 / 耐性 / 細胞接着分子 / 非小細胞肺癌 / 小細胞肺癌 / CADM1 / 肺腺癌 / 増殖因子受容体 / 分子標的 |
Outline of Final Research Achievements |
MET is a receptor of HGF growth factor and is activated by gene amplification and/or overexpression in various cancer to promote cell growth and epithelial to mesenchymal transition. We have demonstrated that a cell adhesion molecule, CADM1, forms a complex with MET on the raft of the cell membrane and suppresses the MET signaling. CADM1 is known to be often inactivated in various cancer cells in their advanced stages. CADM1 could provide a molecular target to suppress oncogenic signaling of cancer cells to malignant growth.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] CRTAM determines the CD4+ cytotoxic T lymphocyte lineage.2016
Author(s)
Takeuchi, A., Badr Mel, S., Miyauchi, K., Ishihara, C., Onishi, R., Guo, Z., Sasaki. Y., Ike, H., Takumi, A., Tsuji, NM., Murakami, Y., Katakai, T., Kubo, M. and Saito, T.
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Journal Title
J. Exp. Med.
Volume: 213
Issue: 1
Pages: 123-138
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] High incidence of null-type mutations of the TP53 gene in Japanese patients with head and neck squamous cell carcinoma.2014
Author(s)
Ebihara Y, Iwai M, Akashi K, Ito T, Omura G, Saito Y, Yoshida M, Ando M, Asakage T, Yamasoba T, Murakami Y.
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Journal Title
Journal of Cancer Therapy
Volume: 5
Pages: 664-671
Related Report
Open Access / Acknowledgement Compliant
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[Journal Article] Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition.2014
Author(s)
Ibrahim R, Matsubara D, Osman W, Morikawa T, Goto A, Morita S, Ishikawa S, Aburatani H, Takai D, Nakajima J, Fukayama M, Niki T, Murakami Y
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Journal Title
Hum Pathol.
Volume: 45
Issue: 7
Pages: 1397-405
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] HPV-associated lung cancers: an international pooled analysis.2014
Author(s)
Ragin C, Obikoya-Malomo M, Kim S, Chen Z, Flores-Obando R, Gibbs D, Koriyama C, Aguayo F, Koshiol J, Caporaso NE, Carpagnano GE, Ciotti M, Dosaka-Akita H, Fukayama M, Goto A et al
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Journal Title
Carcinogenesis
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] High-grade Lung Adenocarcinoma With Fetal Lung-like Morphology: Clinicopathologic, Immunohistochemical, and Molecular Analyses of 17 Cases2013
Author(s)
Morita S, Yoshida A, Goto A, Ota S, Tsuta K, Yokozawa K, Asamura H, Nakajima J, Takai D, Mori M, Oka T, Tamaru J, Itoyama S, Furuta K, Fukayama M, Tsuda H.
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Journal Title
Am J Surg Pathol
Volume: 37(6)
Issue: 6
Pages: 924-932
DOI
Related Report
Peer Reviewed
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[Journal Article] Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates eytokinesis, and its expression correlates with the prognosis of renal cell earcinoma.2013
Author(s)
Shoji K, Mimura I, Murayama T, Wada T, Kume H, Goto A, Ohse T, Tanaka T, Inagi R, van der Hoorn FA, Manabe I, Homma Y, Fukayama M, Sakurai T, Hasegawa T, Aburatani H, Kodama T, Nangaku M.
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Journal Title
American Journal of Pathology
Volume: 182
Issue: 6
Pages: 2191-2203
DOI
Related Report
Peer Reviewed
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[Presentation] Analysis of the role of CADM1 in suppression of lung cancer using Cadm1-deficient mice.2015
Author(s)
Ito T, Nagata M, Kawai T, Maruyama T, Sakurai-Yageta M, Ito A, Goto A, Matsubara D, Murakami Y.
Organizer
AACR Annual Meeting
Place of Presentation
Philadelphia, PA, USA
Year and Date
2015-04-16
Related Report
Int'l Joint Research
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