Identification of genes which shows synthetic lethality in malignant mesothelioma cells and application of them in clinics
| Project/Area Number |
25290053
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
SEKIDO YOSHITAKA 愛知県がんセンター(研究所), 分子腫瘍学部, 副所長兼部長 (00311712)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Yuko (TONAMI Yuko) 愛知県がんセンター(研究所), 分子腫瘍学部, 主任研究員 (70405174)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
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| Keywords | がん / 腫瘍抑制遺伝子 / ゲノム / 悪性中皮腫 / 合成致死 / 癌 |
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| Outline of Final Research Achievements |
Malignant mesothelioma is a highly refractory disease against conventional therapies. Since major genes responsible for malignant mesothelioma development are primarily tumor suppressor genes, it is very difficult to develop molecular target drugs based on these specific gene mutations. We focused on the BAP1 tumor suppressor gene, which is one the most frequently mutated in malignant mesothelioma, and performed genetic screening to identify genes which show synthetic lethality with this genes (synthetic lethality means that simultaneous alterations of two genes induce cell death of cancer cells but not normal cells). We found that several interesting genes show synthetic lethality with BAP1 mutation and can be applied for promising targets for new molecular target therapy against malignant mesothelioma.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascad2014
Author(s)
Tanaka I, Osada H, Fujii M, Fukatsu A, Hida T, Horio Y, Kondo Y, Sato A, Hasegawa Y, Tsujimura T, Sekido Y
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Journal Title
Oncogene
Volume: 34
Issue: 1
Pages: 73-83
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production2013
Author(s)
S. H. Chew, Y. Okazaki, H. Nagai, N. Misawa, S. Akatsuka, K. Yamashita, L. Jiang, Y. Yamashita, M. Noguchi, K. Hosoda, Y. Sekido, T. Takahashi, S. Toyokuni
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Journal Title
Carcinogenesis
Volume: 35(1)
Issue: 1
Pages: 164-172
DOI
Related Report
Peer Reviewed / Open Access
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