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Establishment of quantitation method for proteome-based phospho-signaling pathway and its application for prediction of drug effect monitoring

Research Project

Project/Area Number 25290054
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Tumor diagnostics
Research InstitutionNational Institutes of Biomedical Innovation, Health and Nutrition

Principal Investigator

Tomonaga Takeshi  国立研究開発法人医薬基盤・健康・栄養研究所, プロテオームリサーチプロジェクト, プロジェクトリーダー (80227644)

Co-Investigator(Kenkyū-buntansha) ISHIHAMA Yasushi  京都大学, 薬学部, 教授 (30439244)
MATSUBARA Hisahiro  千葉大学, 医学研究院, 教授 (20282486)
Co-Investigator(Renkei-kenkyūsha) NAGAYAMA Satoshi  公益財団法人がん研究会, 有明病院消化器外科, 医長 (70362499)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywordsリン酸化プロテオミクス / 薬効予測 / EGFR阻害剤 / 肺がん / プロテオミクス / バイオマーカー / リン酸化タンパク質 / がん / リン酸化タンパク
Outline of Final Research Achievements

Molecular target drugs such as kinase inhibitors for cancer treatment are not uniformly clinically effective, thus sorting the patients that will benefit from the treatments is critical. Moreover, acquired resistance for the drugs is also a critical problem. Therefore, the identification of mechanisms underlying the resistance is urgent need. Systematic quantification of kinase activation is potentially predictive of the response of kinase inhibitors and it can be quantitated by phosphorylation level of their substrates. In this study, we developed a large-scale phosphoproteome quantification method for the kinase substrates and applied for prediction of the kinase activities and drug response. We also examined the mechanism of drug resistance. By the phosphoproteome analysis of several lung cancer cell lines which are sensitive or resistant for the drug currently used in clinic, erlotinib, we identified several phosphoproteins and kinases which are able to predict drug sensitivity.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (48 results)

All 2016 2015 2014 2013 Other

All Journal Article (19 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 19 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (27 results) (of which Int'l Joint Research: 1 results,  Invited: 10 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling2016

    • Author(s)
      Yamada K., Miyamoto Y., Tsujii A., Moriyama T., Ikuno Y., Shiromizu T., Serada S., Fujimoto M., Tomonaga T., Naka T., Yoneda Y., Oka M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 231410-231410

    • DOI

      10.1038/srep21410

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.2016

    • Author(s)
      Yamada K., Miyamoto Y., Tsujii A., Moriyama T., Ikuno Y., Shiromizu T., Serada S., Fujimoto M., Tomonaga T., Naka T., Oka M.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 24823-24823

    • DOI

      10.1038/srep24823

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Targeted Phosphoproteome Analysis Using Selected/Multiple Reaction Monitoring (SRM/MRM).2016

    • Author(s)
      Adachi, J., Narumi, R., Tomonaga, T
    • Journal Title

      Methods Mol Biol

      Volume: 1394 Pages: 87-100

    • DOI

      10.1007/978-1-4939-3341-9_7

    • ISBN
      9781493933396, 9781493933419
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Analysis of Tissue Samples by Combining iTRAQ Isobaric Labeling with Selected/Multiple Reaction Monitoring (SRM/MRM).2016

    • Author(s)
      Narumi, R., Tomonaga, T
    • Journal Title

      Methods Mol Biol

      Volume: 1355 Pages: 85-101

    • DOI

      10.1007/978-1-4939-3049-4_6

    • ISBN
      9781493930487, 9781493930494
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Data for Proteomic Analysis of ATP-Binding Proteins and Kinase Inhibitor Target Proteins Using an ATP Probe.2015

    • Author(s)
      Adachi, J., Kishida, M., Watanabe, S., Hashimoto, Y., Fukamizu, K., and Tomonaga, T.
    • Journal Title

      Data in Brief

      Volume: 5 Pages: 726-729

    • DOI

      10.1016/j.dib.2015.10.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear accumulation of annexin A2 contributes to chromosomal instability by coilin-mediated centromere damage2015

    • Author(s)
      Kazami, T., Nie, H., Satoh, M., Kuga, T., Matsushita, K., Kawasaki, N., Tomonaga, T*., and Nomura, F
    • Journal Title

      Oncogene

      Volume: in press Issue: 32 Pages: 4177-4189

    • DOI

      10.1038/onc.2014.345

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential Proteome Analysis Identifies TGF-beta-Related Pro-Metastatic Proteins in a 4T1 Murine Breast Cancer Model.2015

    • Author(s)
      Sato, M., Matsubara, T., Adachi, J., Hashimoto, Y., Fukamizu, K., Kishida, M., Yang, Y.A., Wakefield, L.M., and Tomonaga, T
    • Journal Title

      PloS One

      Volume: 10 Issue: 5 Pages: e0126483-e0126483

    • DOI

      10.1371/journal.pone.0126483

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.2015

    • Author(s)
      Kazumasa Aoyama, Noritaka Yamaguchi, Ryuzaboro Yuki, Mariko Morii, Sho Kubota, Kensuke Hirata, Kohei Abe, Takuya Honda, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi
    • Journal Title

      Cell Biology International

      Volume: 39 Issue: 4 Pages: 446-456

    • DOI

      10.1002/cbin.10413

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Role for Tyrosine Phosphorylation of A-kinase Anchoring Protein 8 (AKAP8) in its Dissociation from Chromatin and the Nuclear Matrix2015

    • Author(s)
      Kubota S, Morii M, Yuki R, Yamaguchi N, Yamaguchi H, Aoyama K, Kuga T, Tomonaga T, Yamaguchi N.
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 17 Pages: 10891-904

    • DOI

      10.1074/jbc.m115.643882

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] c-Abl-mediated tyrosine phosphorylation of JunB is required for Adriamycin-induced expression of p21.2015

    • Author(s)
      Noritaka Yamaguchi, Ryuzaburo Yuki, Sho Kubota, Kazumasa Aoyama, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi.
    • Journal Title

      Biochemical Journal

      Volume: 471 Issue: 1 Pages: 67-77

    • DOI

      10.1042/bj20150372

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.2015

    • Author(s)
      Takeuchi, M., Higashino, A., Takeuchi, K., Hori, Y., Koshiba-Takeuchi, K., Makino, H., Monobe, Y., Kishida, M., Adachi, J., Takeuchi, J., Tomonaga, T., Umezawa, A., Kameoka, Y., and Akagi, K.
    • Journal Title

      PloS one

      Volume: 10 Issue: 5 Pages: 0126562-0126562

    • DOI

      10.1371/journal.pone.0126562

    • NAID

      120005947126

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential proteome analysis identifies TGF-β-related pro-metastatic proteins in a 4T1 murine breast cancer model.2015

    • Author(s)
      Sato M, Matsubara T, Adachi J, Hashimoto Y, Kishida M, Yang Y, Wakefield LM, Tomonaga T*
    • Journal Title

      PLoS One

      Volume: in press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proteome-wide discovery of unknown ATP-binding proteins and kinase inhibitor target proteins using an ATP probe.2014

    • Author(s)
      Jun Adachi, Marina Kishida, Shio Watanabe, Yuuki Hashimoto, Kazuna Fukamizu, Takeshi Tomonaga.
    • Journal Title

      Journal of proteome research

      Volume: 13 Issue: 12 Pages: 5461-5470

    • DOI

      10.1021/pr500845u

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of colorectal cancer biomarker candidates by membrane proteomic analysisand subsequent verification using selected reaction monitoring and tissue microarrayanalysis2014

    • Author(s)
      Kume H, Muraoka S, Kuga T, Adachi J, Narumi R, Watanabe S, Kuwano M, Kodera Y, Matsushita K, Fukuoka J, Masuda T, Ishihama Y, Matsubara H, Nomura F, Tomonaga T.
    • Journal Title

      Mol Cell Proteomics.

      Volume: M113 Issue: 6 Pages: 37093-37093

    • DOI

      10.1074/mcp.m113.037093

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamin B2 prevents chromosome instability by ensuring proper mitotic chromosome segregation2013

    • Author(s)
      Kuga, T., Nie, H., Kazami, T., Satoh, M., Matsushita, K., Nomura, F., Maeshima, K., Nakayama, Y., Tomonaga, T.
    • Journal Title

      Oncogenesis

      Volume: 3 Issue: 3 Pages: e94-e94

    • DOI

      10.1038/oncsis.2014.6

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Absolute Quantitation of Low Abundance Plasma APL1β peptides at Sub-fmol/mL Level by SRM/MRM without Immunoaffinity Enrichment.2013

    • Author(s)
      Sano S, Tagami S, Hashimoto Y, Yoshizawa-Kumagaye K, Tsunemi M, Okochi M, Tomonaga T.
    • Journal Title

      J Proteome Res.

      Volume: 13 Issue: 2 Pages: 10121020-10121020

    • DOI

      10.1021/pr4010103

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mechanism of keratin cytoskeleton organization through casein kinase I alpha and FAM83H in colorectal cancer.2013

    • Author(s)
      Kuga, T., Kume, H., Kawasaki, N., Sato, M., Adachi, J., Shiromizu, T., Hoshino, I., Nishimori, T., Matsubara, H., and Tomonaga T.
    • Journal Title

      J Cell Sci

      Volume: 126 Pages: 4721-31

    • DOI

      10.1242/jcs.129684

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Formation of long and winding nuclear F-actin bundles by nuclear c-Abl tyrosine kinase.2013

    • Author(s)
      Aoyama K., Yuki R., Horiike Y., Kubota S., Yamaguchi N., Morii M., Ishibashi K., Nakayama Y., Kuga T., Hashimoto Y., Tomonaga T, and Yamaguchi N.
    • Journal Title

      Exp Cell Res

      Volume: 319 Issue: 20 Pages: 3251-68

    • DOI

      10.1016/j.yexcr.2013.09.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phosphorylation of KRAB-associated Protein 1 (KAP1) at Tyr-449, Tyr-458, and Tyr-517 by Nuclear Tyrosine Kinases Inhibits the Association of KAP1 and Heterochromatin Protein 1alpha (HP1alpha) with Heterochromatin.2013

    • Author(s)
      Kubota, S., Fukumoto, Y., Aoyama, K., Ishibashi, K., Yuki, R., Morinaga, T., Honda, T., Yamaguchi, N., Hashimoto, Y., Kuga, T., Tomonaga T, and Yamaguchi, N.
    • Journal Title

      J Biol Chem

      Volume: 288, Issue: 24 Pages: 17871-17883

    • DOI

      10.1074/jbc.m112.437756

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] プロテオミクスを用いたバイオマーカー探索とPrecision Medicineへの応用2016

    • Author(s)
      朝長 毅
    • Organizer
      第44回 京阪泌尿器腫瘍セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2016-02-08
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 定量プロテオミクスの創薬及び個別化医療への応用2016

    • Author(s)
      朝長 毅
    • Organizer
      第13回 神戸ポートアイランド創薬フォーラム
    • Place of Presentation
      神戸臨床研究情報センター
    • Year and Date
      2016-01-26
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 定量プロテオミクスを用いた疾患バイオマーカー探索とその医療への応用2015

    • Author(s)
      朝長 毅
    • Organizer
      日本プロテオーム学会2015年会
    • Place of Presentation
      くまもと森都心プラザ
    • Year and Date
      2015-07-23
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 定量プロテオミクスの医療への応用2015

    • Author(s)
      朝長 毅
    • Organizer
      第42回BMSカンファレンス
    • Place of Presentation
      岐阜グランドホテル
    • Year and Date
      2015-07-06
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Verification of predictive biomarker candidates of colorectal cancer metastasis in serum extracellular vesicles by selected reaction monitoring based targeted proteomics.2015

    • Author(s)
      Tomonaga T, Kume H
    • Organizer
      International Extracellular Vesicles Conference
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 定量プロテオミクスの医療への応用2015

    • Author(s)
      朝長 毅
    • Organizer
      第150回 質量分析関西談話会
    • Place of Presentation
      大阪
    • Year and Date
      2015-03-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Identification of predictive biomarker candidates of colorectal cancer metastasis in serum extracellular vesicles based on membrane quantitative proteomics of cancer tissues.2014

    • Author(s)
      Tomonaga T, Kume H
    • Organizer
      Australasia Extracellular Vesicles Conference
    • Place of Presentation
      Kerns, Australia
    • Year and Date
      2014-11-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] Discovery of colorectal cancer biomarker candidates by membrane proteomic analysis and subsequent verification using selected reaction monitoring2014

    • Author(s)
      Tomonaga T, Kume H
    • Organizer
      Human Proteome Organization (HUPO) 13th Annual World Congress
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2014-10-05 – 2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] Discovery of colorectal cancer biomarker candidates by membrane proteomic analysis of human tissue samples and subsequent verification using SRM/MRM2014

    • Author(s)
      Tomonaga T
    • Organizer
      The 13th HUPO World Congress Post Congress Workshop
    • Place of Presentation
      Segovia, Spain
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 質量分析計を用いたバイオマーカー定量法の実用化(医療への応用)2014

    • Author(s)
      朝長 毅
    • Organizer
      レドックス・ライフイノベーション第170委員会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-08-22
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 質量分析計を用いたバイオマーカー定量法の創薬への応用を目指して2014

    • Author(s)
      朝長 毅
    • Organizer
      第12回日本プロテオーム学会2014年会
    • Place of Presentation
      つくば
    • Year and Date
      2014-07-17
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 質量分析計を用いたバイオマーカー定量法の実用化(医療への応用)2014

    • Author(s)
      朝長 毅
    • Organizer
      第14回日本蛋白質科学会
    • Place of Presentation
      神奈川
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 質量分析計を用いたバイオマーカー定量法の医療への応用2014

    • Author(s)
      朝長 毅
    • Organizer
      第10回日本臨床プロテオーム研究会
    • Place of Presentation
      東京
    • Year and Date
      2014-05-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 質量分析計を用いたバイオマーカー定量法の実用化2014

    • Author(s)
      朝長 毅
    • Organizer
      第11 回 北里疾患プロテオミクス研究会
    • Place of Presentation
      神奈川
    • Related Report
      2013 Annual Research Report
  • [Presentation] ターゲットプロテオミクス~Beyond SRM~2013

    • Author(s)
      足立 淳、朝長 毅
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 質量分析計を用いたバイオマーカー定量法の実用化への挑戦2013

    • Author(s)
      朝長 毅
    • Organizer
      第10 回 千葉疾患プロテオミクス研究会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] 自己抗体ファージライブラリを用いたスキルス胃癌の診断バイオマーカーの探索2013

    • Author(s)
      村岡 賢,久米秀明,西塚 哲,若林 剛,星野 敢,松原久裕,朝長 毅
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス同所移植モデルによる大腸癌高浸潤性細胞のプロテオーム解析2013

    • Author(s)
      白水 崇、足立 淳、八木 滋雄、朝長 毅
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ATP Accessibility Screening (AAS), A High-Throughput and High-Resolution Kinase Analysis Platform for Signaling Research.2013

    • Author(s)
      Adachi J, Higo D, Watanabe S, Kuwano M, Hashimoto Y, Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Discovery and subsequent validation of biomarkers for colorectal cancer by large-scale proteomic analysis and tissue microarray analysis.2013

    • Author(s)
      Kume H, Muraoka S, Hashimoto Y, Watanabe S, Masuda T, Ishihama Y, Fukuoka J, Kodera Y, Matsushita K, Matsubara H, Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Proteomic Analysis of Highly Invasive Colorectal Cancer Cells Established byOrthotopic Xenograft Mouse Model.2013

    • Author(s)
      Shiromizu T, Adachi J, Yagi S, Hoffman RM, Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of High-throughput Screening System Using Autoantibody Library for Discovery of Scirrhous Gastric Cancer Biomarker.2013

    • Author(s)
      Muraoka S, Kume H, Saitoh H, Enomoto Y, Ito Y, Nishizuka S, Wakabayashi G, Hoshino I, Matsubara H, and Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantitative Phosphoproteome Analysis of Cultured Stomach Cancer Cell Lines Aimed at Development of Biomarkers for Prediction of Drug Efficacy.2013

    • Author(s)
      Hashiguchi K, Muraoka S, Adachi J, Sato M, Kuga T, Watanabe R, Shiromizu T, Hashimoto Y, Nagano M, Kishida M, Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Quantitative Proteome Analysis with Isotope Dimethyl Labeling to Identify TGF-beta-mediated Tumor Proteins Using the Metastatic Mouse Breast Cancer Model.2013

    • Author(s)
      Sato M, Adachi J, Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Phospho-profiling of mTOR inhibitor-treated renal cell carcinoma (RCC) cell lines and its application for drug response-efficacy biomarkers.2013

    • Author(s)
      Watanabe R, Hashimoto Y, Kishida M, Matsubara M, Adachi J, Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Novel Mechanism of Keratin Cytoskeleton Organization Through Casein Kinase I Alpha and FAM83H in Colorectal Cancer: Interactome Analysis of FAM83H2013

    • Author(s)
      Kuga T, Kume H, Kawasaki N, Sato M, Adachi J, Shiromizu T, Hoshino I, Matsubara H, Tomonaga T. .
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] A Kinase Activity-Estimating Method Using LC-MS/MS.2013

    • Author(s)
      Nagano M, Kuga T, Adachi J, Tomonaga T.
    • Organizer
      Human Proteome Organization (HUPO) 12th annual world congress
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Remarks] 国立研究開発法人医薬基盤・健康・栄養研究所 プロテオームリサーチプロジェクト

    • URL

      http://www.nibiohn.go.jp/proteome/index.html

    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] ペプチド又はタンパク質の分画方法2015

    • Inventor(s)
      朝長 毅、足立 淳、宮崎将太
    • Industrial Property Rights Holder
      ジーエルサイエンス 株式会社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-134482
    • Filing Date
      2015-07-03
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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