| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Outline of Final Research Achievements |
As cancer cells generally require a lot of glucose for proliferation, stress adaptation mechanisms coupled with energy metabolism play an essential role in cancer cell survival under tumor microenvironment where supply of glucose is not enough. In this study, we analyzed mitochondria-dependent and -independent mechanisms of cellular stress response under nutrient deprivation conditions, and found several regulatory proteins for each mechanism. We further evaluated the identified proteins as novel targets for drug discovery.
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