Elucidation of cooperative mechanisms between energy metabolism and stress response of cancer cells for drug discovery
| Project/Area Number |
25290061
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Tomida Akihiro 公益財団法人がん研究会, がん化学療法センター ゲノム研究部, 部長 (40251483)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2015: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Keywords | 癌 / 分子標的治療 / 微小環境 / グルコース / ストレス応答 |
|---|
| Outline of Final Research Achievements |
As cancer cells generally require a lot of glucose for proliferation, stress adaptation mechanisms coupled with energy metabolism play an essential role in cancer cell survival under tumor microenvironment where supply of glucose is not enough. In this study, we analyzed mitochondria-dependent and -independent mechanisms of cellular stress response under nutrient deprivation conditions, and found several regulatory proteins for each mechanism. We further evaluated the identified proteins as novel targets for drug discovery.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation2015
Author(s)
Mashima T, Ushijima M, Matsuura M, Tsukahara S, Kunimasa K, Furuno A, Saito S, Kitamura M, Soma-Nagae T, Seimiya H, Dan S, Yamori T, Tomida A
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Journal Title
Cancer Science
Volume: in press
Issue: 7
Pages: 909-920
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact2013
Author(s)
Migita, T., Okabe, S., Ikeda, K., Igarashi, S., Sugawara, S., Tomida, A., Taguchi, R., Soga, T., Seimiya, H.
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Journal Title
Am J Pathol.
Volume: 182
Issue: 5
Pages: 1800-1810
DOI
Related Report
Peer Reviewed
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