• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of tumor targeting technology in combination of tumor-homing peptide and nanoparticles

Research Project

Project/Area Number 25290062
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Tumor therapeutics
Research InstitutionNiigata University (2014-2015)
愛知県がんセンター(研究所) (2013)

Principal Investigator

Kondo Eisaku  新潟大学, 医歯学系, 教授 (30252951)

Co-Investigator(Kenkyū-buntansha) Koga Hironori  久留米大学, 医学部, 教授 (90268855)
瀧川 奈義夫  川崎医科大学, 医学部, 教授 (60325107)
Co-Investigator(Renkei-kenkyūsha) Takigawa Nagio  川崎医科大学, 医学部, 教授 (60325107)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywordsペプチド / 腫瘍 / 膵がん / 胆管がん / 脳腫瘍 / がん / 分子標的 / ドラッグデリバリー / 遺伝子診断・治療
Outline of Final Research Achievements

Consequently, peptide-dendrimer or peptide-liposome conjugates showed their accumulation to the liver in vivo, although its maginitude of accumulation was decreased in comparison with those of the dendrimer or liposome alone. Taking this into consideration, we changed the strategy from generating the peptide-nano particle conjugates that enhance the delivery to the target tumor tissues, to obtain the highly efficient tumor-targeting peptides by isolating them from the random peptide library. As a result, we succeeded identifying the novel superior tumor-homing peptides such as pancreatic cancer-homing, bile duct cancer-hoiming, and glioblastoma-homing peptides. Patentapplications for these tumor-targeting peptides have been completed, and we are preparing PCT application now.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (37 results)

All 2016 2015 2014 2013 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 11 results,  Open Access: 5 results) Presentation (15 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (5 results)

  • [Journal Article] GANP protein encoded on human chromosome 21/mouse chromosome 10 is associated with resistance to mammary tumor development.2016

    • Author(s)
      Kuwahara K, Yamamoto-Ibusuki M, Zhang Z, Phimsen S, Gondo N, Yamashita H, Takeo T, Nakagata N, Yamashita D, Fukushima Y, Yamamoto Y, Iwata H, Saya H, Kondo E, Matsuo K, Takeya M, Iwase H, Sakaguchi N.
    • Journal Title

      Cancer Sci

      Volume: in press Issue: 4 Pages: 469-477

    • DOI

      10.1111/cas.12883

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a cancer-homing transporter.2015

    • Author(s)
      Higa M, Katagiri C, Shimizu-Okabe C, Tsumuraya T, Sunagawa M, Nakamura M, Ishiuchi S, Takayama C, Kondo E, Matsushita M.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 457(2) Issue: 2 Pages: 206-12

    • DOI

      10.1016/j.bbrc.2014.12.089

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 糖鎖型細胞透過性ペプチドによる生体腫瘍イメージング技術構築の試み2015

    • Author(s)
      下田泰治・近藤英作
    • Journal Title

      メディカル・サイエンス・ダイジェスト

      Volume: 41 Pages: 38-41

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 糖鎖型細胞透過性ペプチドによる生体腫瘍イメージング技術構築の試み2015

    • Author(s)
      下田泰治・近藤英作
    • Journal Title

      バイオクリニカ

      Volume: 30 Pages: 89-92

    • Related Report
      2015 Annual Research Report
  • [Journal Article] NF-κB factors control the induction of NFATc1 in B lymphocytes.2014

    • Author(s)
      Muhammad K, Alrefai H, Marienfeld R, Pham DA, Murti K, Patra AK, Avots A, Bukur V, Sahin U,Kondo E, Klein-Hessling S, Serfling E.
    • Journal Title

      Eur J Immunol.

      Volume: 44(11) Issue: 11 Pages: 3392-402

    • DOI

      10.1002/eji.201444756

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deficient HER3 expression in poorly-differentiated colorectal cancer cells enhances gefitinib sensitivity2014

    • Author(s)
      Nakata S, Tanaka H, Ito Y, Hara M, Fujita M, Kondo E, Kanemitsu Y, Yatabe Y and Nakanishi H
    • Journal Title

      International Journal of Oncology

      Volume: 45 Issue: 4 Pages: 1583-1593

    • DOI

      10.3892/ijo.2014.2538

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extract of Cordyceps militaris inhibits angiogenesis and suppresses tumor growth of human malignant melanoma cells.2014

    • Author(s)
      Ruma IMW, Putranto EW, Kondo E, Watanabe R, Saito K, Inoue Y, Yamamoto K, Nakata S,Kaihata M, Murata H and Sakaguchi M.
    • Journal Title

      Int J Oncol.

      Volume: 45(1) Issue: 1 Pages: 209-18

    • DOI

      10.3892/ijo.2014.2397

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a New Rapid Isolation Device for Circulating Tumor Cells (CTCs) Using 3D Palladium Filter and Its Application for Genetic Analysis2014

    • Author(s)
      30) A Yusa, M Toneri, T Masuda, M Okochi, H Iwata, H Honda, F Arai, H Nakanishi.
    • Journal Title

      PLOS ONE

      Volume: 9(2):e88821 Issue: 2 Pages: 1-11

    • DOI

      10.1371/journal.pone.0088821

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells2013

    • Author(s)
      Saito K and Sakaguchi M
    • Journal Title

      Oncogene

      Volume: in press Issue: 10 Pages: 1274-1286

    • DOI

      10.1038/onc.2013.66

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] New whole-body multimodality imaging of gastric cancer peritoneal metastasis combining fluorescence imaging with ICG-labeled antibody and MRI in mice.2013

    • Author(s)
      Ito A, Ito Y, Matsushima S, Tsuchida D, Ogasawara M, Hasegawa J, Misawa K, Kondo E, Kaneda N, Nakanishi H.
    • Journal Title

      Gastric Cancer

      Volume: 17 Issue: 3 Pages: 497-507

    • DOI

      10.1007/s10120-013-0316-0

    • NAID

      40020216067

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Defect of mitotic vimentin phosphorylation causes microophthalmia and cataract via aneuploidy and senescence in lens epithelial cells.2013

    • Author(s)
      Matsuyama, M.
    • Journal Title

      J. Biol. Chem.

      Volume: 288 Issue: 50 Pages: 35626-35635

    • DOI

      10.1074/jbc.m113.514737

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of new intraperitoneal paclitaxel-resistant gastric cancer cell lines and comprehensive gene expression analysis.2013

    • Author(s)
      Murakami H, Ito S, Tanaka H, Kondo E, Kodera Y, Nakanishi H.
    • Journal Title

      Anticancer Res.

      Volume: 33(10) Pages: 4299-307

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor Impact of p14ARF on Gefitinib-Resistant Non-Small Cell Lung Cancers.2013

    • Author(s)
      Saito K, Takigawa N, Ohtani N, Iioka H, Tomita Y, Ueda R, Fukuoka J, Kuwahara K, Ichihara E, Kiura K, Kondo E.
    • Journal Title

      Molecule Cancer Therapeutics

      Volume: 12 Issue: 8 Pages: 1616-1628

    • DOI

      10.1158/1535-7163.mct-12-1239

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Restoration of tumor suppressor function by mitochondrially targeting p14 peptide in tumor cells.2015

    • Author(s)
      Ken Saito, Eisaku Kondo
    • Organizer
      The 2015 AACR-NCI-EORTC INTERNATIONAL CONFERENCE Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Hynes convention center (USA, MA・Boston)
    • Year and Date
      2015-11-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 機能性ペプチドが拓く新しい制がん技術2015

    • Author(s)
      近藤英作
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-10-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 新規がんターゲティングペプチド開発へのトライアル2015

    • Author(s)
      近藤英作
    • Organizer
      平成27年度日本生化学会関東支部
    • Place of Presentation
      新潟日報メディアシップ(新潟県・新潟市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 膵がん間質に存在する間葉系幹細胞の細胞機能の解析2015

    • Author(s)
      近藤英作、飯岡英和、斎藤憲
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] p14機能性ペプチドによる高悪性度腫瘍の増殖抑制2014

    • Author(s)
      近藤英作、齋藤憲
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胆道がんにおける腫瘍ホーミングペプチドの開発2014

    • Author(s)
      齋藤憲、近藤英作
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞極性制御因子Crb3の腫瘍の進展における機能の解析2014

    • Author(s)
      飯岡英和、齋藤憲、森井英一、近藤英作
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肝および腹膜転移性胃がんの原発巣ならびに転移巣におけるHER2/EGFR発現の検討2014

    • Author(s)
      齊藤卓也、中西速夫、谷田部恭、伊藤誠二、山道啓吾、近藤英作
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] p14ARF機能性ペプチドによる悪性腫瘍細胞の増殖抑制2014

    • Author(s)
      近藤英作、齋藤憲
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] 標的細胞吸収性ペプチドを応用した制がんを目的とするpeptide-based DDS構築へのアプローチ2014

    • Author(s)
      近藤英作
    • Organizer
      平成25 年度 がん支援活動公開シンポジウム
    • Place of Presentation
      東京(学術総合センター(一ツ橋講堂))
    • Related Report
      2013 Annual Research Report
  • [Presentation] ペプチドを応用した新規生体低侵襲性制がんDDS技術の開発研究2014

    • Author(s)
      近藤英作
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台(仙台国際センター)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Development of the Tumor-homing peptides and its application for the next-generation tumor medicine.2013

    • Author(s)
      Kondo E, Saito K, Iioka H, Watanabe R.
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ゲフィティニブ耐性肺癌におけるp14ARFの機能制御2013

    • Author(s)
      斎藤憲、中西速夫、近藤英作
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] アイソフォーム特異的モノクロナル抗体を用いたがん組織におけるCrb3aの機能解析2013

    • Author(s)
      飯岡英和、斎藤憲、山下大祐、住友誠、加藤英史、近藤英作
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腫瘍および腫瘍環境構成細胞吸収性新規細胞膜透過ペプチドの開発研究2013

    • Author(s)
      近藤英作
    • Organizer
      文部科学省新学術領域研究「がん微小環境」班会議
    • Place of Presentation
      東京(東京大学小柴ホール)
    • Related Report
      2013 Annual Research Report
  • [Book] G.I. Research 特集 消化器腫瘍の分子イメージング2014

    • Author(s)
      近藤英作
    • Total Pages
      112
    • Publisher
      先端医学社
    • Related Report
      2014 Annual Research Report
  • [Book] G.I. Research (Journal of Gastrointestinal Research) 特集 消化器腫瘍の分子イメージング2014

    • Author(s)
      近藤英作
    • Total Pages
      112
    • Publisher
      先端医学社
    • Related Report
      2013 Annual Research Report
  • [Remarks] 新潟大学大学院医歯学総合研究科分子細胞病理学 研究トピックス

    • URL

      http://www.med.niigata-u.ac.jp/pa2/

    • Related Report
      2014 Annual Research Report
  • [Remarks] イレッサ耐性肺がんの特徴と抗腫瘍ペプチドによる標的

    • URL

      http://www.pref.aichi.jp/cancer-center/ri/01bumon/02shuyo_byori/index.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 胆道癌に特異的な集積性を有するペプチド及びその使用2015

    • Inventor(s)
      近藤英作、斎藤憲
    • Industrial Property Rights Holder
      近藤英作、斎藤憲
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 脳腫瘍特異的イメージングペプチド2015

    • Inventor(s)
      近藤英作、斎藤憲
    • Industrial Property Rights Holder
      近藤英作、斎藤憲
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 膵がん高度集積性短鎖ペプチド2015

    • Inventor(s)
      近藤英作、斎藤憲
    • Industrial Property Rights Holder
      近藤英作、斎藤憲
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-11-19
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] 大腸癌細胞選択的膜透過性ペプチドおよびその利用2015

    • Inventor(s)
      近藤英作、松下正之
    • Industrial Property Rights Holder
      近藤英作、松下正之
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Patent(Industrial Property Rights)] アデノウイルスベクターをがん細胞に対して選択的に導入可能なポリペプチドおよび当該ポリペプチドを備えるアデノウイルスベクター2013

    • Inventor(s)
      近藤英作、阪口政清、許 南浩、手塚克成
    • Industrial Property Rights Holder
      近藤英作、阪口政清、許 南浩、手塚克成
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-085969
    • Filing Date
      2013-04-04
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2023-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi