| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
The chordate nervous systems consist of diverse cell types of neurons and glia, which develop from common progenitor cells. Temporally and spatially precise control of development of neural cell types is the base for proper function of the nervous system, yet the molecular and cellular mechanisms that control cell-type specification have been only partially elucidated. We have used two simple model chordates, the tunicate Ciona intestinalis and the medaka fish Oryzias latipes, to study genomic regulatory networks for the development of diverse cell-types in the chordate nervous system. We systematically identified promoters in the Ciona genome and analyzed interactions between transcription factors and cis-regulatory DNAs. We also determined the precise cell lineage, from the fertilized egg to the terminal differentiation, of particular cell types in the brain of the C. intestinelails. In medaka, we have identified microRNAs as a regulator for the development of neuronal cell types.
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