Studies on genomic regulatory networks for development of diverse cell-types in chordate nervous systems
Project/Area Number |
25290067
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Genome biology
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Research Institution | Konan University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NAKAI Kenta 東京大学, 医科学研究所, 教授 (60217643)
SUZUKI Yutaka 東京大学, 大学院新領域創成科学研究科, 教授 (40323646)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2014: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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Keywords | ホヤ / メダカ / 転写調節 / 神経系 / 発生・分化 / 小分子RNA / 感覚器 |
Outline of Final Research Achievements |
The chordate nervous systems consist of diverse cell types of neurons and glia, which develop from common progenitor cells. Temporally and spatially precise control of development of neural cell types is the base for proper function of the nervous system, yet the molecular and cellular mechanisms that control cell-type specification have been only partially elucidated. We have used two simple model chordates, the tunicate Ciona intestinalis and the medaka fish Oryzias latipes, to study genomic regulatory networks for the development of diverse cell-types in the chordate nervous system. We systematically identified promoters in the Ciona genome and analyzed interactions between transcription factors and cis-regulatory DNAs. We also determined the precise cell lineage, from the fertilized egg to the terminal differentiation, of particular cell types in the brain of the C. intestinelails. In medaka, we have identified microRNAs as a regulator for the development of neuronal cell types.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Genome-wide identification and characterization of transcription start sites and promoters in the tunicate Ciona intestinalis2016
Author(s)
Yokomori, R., Shimai, K., Nishitsuji, K., Suzuki, Y., Kusakabe, T. G., and Nakai K.
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Journal Title
Genome Research
Volume: 26
Issue: 1
Pages: 140-150
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] The pre-vertebrate origins of neurogenic placodes2015
Author(s)
Abitua, P. B., Gainous, T. B., Kaczmarczyk, A. N., Winchell, C. J., Hudson, C., Kamata, K., Nakagawa, M., Tsuda, M., Kusakabe, T. G., and Levine, M.
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Journal Title
Nature
Volume: 524
Issue: 7566
Pages: 462-465
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Functional and structural evidence for a central pattern generator controlling swimming locomotion of the Ciona intestinalis larva2013
Author(s)
Takehiro G. Kusakabe, Koki Nishitsuji, Daisuke Moriguchi, Hiroki Kashiwagi, Kotaro Shimai, Daiske Honda, Masashi Nakagawa, Masamichi Ohkura, Junichi Nakai, Yasunori Sasakura, Takeo Horie
Organizer
7th International Tunicate Meeting
Place of Presentation
Naples, Italy
Related Report
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