Analysis of time constant encoded in circadian clock proteins
| Project/Area Number |
25291039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Institute for Molecular Science |
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Principal Investigator |
AKIYAMA Shuji 分子科学研究所, 協奏分子システム研究センター, 教授 (50391842)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | 概日時計 / 生物時計 / タンパク質 / タイミング |
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| Outline of Final Research Achievements |
This research project aims at analyzing pre-steady-state relaxations of the ATPase activity of a clock protein, KaiC, which is known to be a pacemaker of the circadian clock system in cyanobacteria. A fine correlation between the relaxation time of KaiC alone and the clock-system’s frequency supports the idea that the slow ATPase in KaiC yields the circadian response frequency of intermolecular interactions with other clock-related proteins.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Atomic-scale origins of slowness in the cyanobacterial circadian clock2015
Author(s)
J. Abe, T. B. Hiyama, A. Mukaiyama, S. Son, T. Mori, S. Saito, M. Osako, J. Wolanin, E. Yamashita, T. Kondo, S. Akiyama
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Journal Title
Science
Volume: 349
Issue: 6245
Pages: 312-316
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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