| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Outline of Final Research Achievements |
We aimed to discover new cellular functions of the microtubule cytoskeleton in fission yeast. Our study discovered a new function of microtubules at the beginning of meiosis. The microtubule array interacts with kinetochores of chromosomes, thereby repositioning the arrangement of chromosomes in the nucleus after meiotic recombination. Importantly, the microtubule organization is essential for faithful chromosome segregation in meiosis.
We also investigated molecular mechanisms as to how microtubules are organized in yeast cells. We found that the Alp7-Alp14 complex (MAPs) play pivotal roles in microtubule formation.
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