| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Outline of Final Research Achievements |
Autophagy-dependent degradation selective for mitochondria, termed mitophagy, is a fundamental mechanism conserved from yeast to humans that contributes to mitochondrial quality and quantity control. In this study, we analyzed yeast mutants and demonstrated that phospholipid methyltransferase, protein N-terminal acetyltransferase, and nascent polypeptide chain-associated factor are important for efficient mitophagy.
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