Regulatory mechanisms and molecular bases of selective mitochondria degradation
Project/Area Number |
25291045
|
Research Category |
Grant-in-Aid for Scientific Research (B)
|
Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
|
Research Institution | Osaka University |
Principal Investigator |
OKAMOTO Koji 大阪大学, 生命機能研究科, 准教授 (40455217)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
Keywords | ミトコンドリア / オートファジー / リン脂質メチル化酵素 / タンパク質N末端アセチル化酵素 / 新生ポリペプチド鎖結合因子 / 出芽酵母 / 酵母 / 品質管理 / オルガネラ膜動態 |
Outline of Final Research Achievements |
Autophagy-dependent degradation selective for mitochondria, termed mitophagy, is a fundamental mechanism conserved from yeast to humans that contributes to mitochondrial quality and quantity control. In this study, we analyzed yeast mutants and demonstrated that phospholipid methyltransferase, protein N-terminal acetyltransferase, and nascent polypeptide chain-associated factor are important for efficient mitophagy.
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Phospholipid methylation controls Atg32-mediated mitophagy and Atg8 recycling2015
Author(s)
Sakakibara K, Eiyama A, Suzuki SW, Sakoh-Nakatogawa M, Okumura N, Tani M, Hashimoto A, Nagumo S, Kondo-Okamoto N, Kondo-Kakuta C, Asai E, Kirisako H, Nakatogawa H, Kuge O, Takao T, Ohsumi Y, Okamoto K
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Journal Title
EMBO Journal
Volume: 34
Issue: 21
Pages: 2703-2719
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation.2015
Author(s)
Murakawa T, Yamaguchi O, Hashimoto A, Hikoso S, Takeda T, Oka T, Yasui H, Ueda H, Akazawa Y, Nakayama H, Taneike M, Misaka T, Omiya S, Shah AM, Yamamoto A, Nishida K, Ohsumi Y, Okamoto K, Sakata Y, Otsu K.
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Journal Title
Nat Commun.
Volume: 6
Issue: 1
Pages: 7527-7527
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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