| Project/Area Number |
25291046
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
Mihara Katsuyoshi 九州大学, 医学(系)研究科(研究院), 名誉教授 (40029963)
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| Co-Investigator(Kenkyū-buntansha) |
OOtera Hidenori 九州大学, 大学院医学研究院, 助教 (40380612)
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| Co-Investigator(Renkei-kenkyūsha) |
ISIHARA NAOTADA 久留米大学, 分子生命科学研究所, 教授 (10325516)
Noimura Masahisa 九州大学, 大学院医学研究院, 講師 (30315080)
Masuda Keiji 九州大学, 大学院歯学病院, 講師 (60392122)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | ミトコンドリア / ミトコンドリア融合 / ミトコンドリア分裂 / アポトーシス / ミトコンドリアダイナミクス / Drp1 / OPA1 / cytochrome c / Mff / Mid / Mfn |
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| Outline of Final Research Achievements |
Mitochondrial fission-facilitated cytochrome c release from the mitochondrial critae into the cytoplasm constitutes the key step of intrinsic apoptosis, although how the mitochondrial fission GTPase Drp1 and its mitochondrial receptors Fis1, Mff, MiD49, and MiD51 are involved in this reaction remained elusive. We found with the fission factors-KO cell lines that Drp1-dependent mitochondrial fission through MiD49/MiD51, but not through the other factors, regulates cytochrome c release by cristae remodeling during intrinsic apoptosis.
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