Molecular Mechanisms of Mitochondrial Fission
Project/Area Number |
25291046
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Cell biology
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Research Institution | Kyushu University |
Principal Investigator |
Mihara Katsuyoshi 九州大学, 医学(系)研究科(研究院), 名誉教授 (40029963)
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Co-Investigator(Kenkyū-buntansha) |
OOtera Hidenori 九州大学, 大学院医学研究院, 助教 (40380612)
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Co-Investigator(Renkei-kenkyūsha) |
ISIHARA NAOTADA 久留米大学, 分子生命科学研究所, 教授 (10325516)
Noimura Masahisa 九州大学, 大学院医学研究院, 講師 (30315080)
Masuda Keiji 九州大学, 大学院歯学病院, 講師 (60392122)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | ミトコンドリア / ミトコンドリア融合 / ミトコンドリア分裂 / アポトーシス / ミトコンドリアダイナミクス / Drp1 / OPA1 / cytochrome c / Mff / Mid / Mfn |
Outline of Final Research Achievements |
Mitochondrial fission-facilitated cytochrome c release from the mitochondrial critae into the cytoplasm constitutes the key step of intrinsic apoptosis, although how the mitochondrial fission GTPase Drp1 and its mitochondrial receptors Fis1, Mff, MiD49, and MiD51 are involved in this reaction remained elusive. We found with the fission factors-KO cell lines that Drp1-dependent mitochondrial fission through MiD49/MiD51, but not through the other factors, regulates cytochrome c release by cristae remodeling during intrinsic apoptosis.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Dynamics of mtDNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development.2015
Author(s)
T. Ishihara, R. Ban-Ishihara, M. Maeda, Y. Matsunaga, A. Ichimura, S. Kyogoku, H. Aoki, S. Katadam K. Nakada, M. Nomura, N. Mizushima, K. Mihara, and N. Ishihara
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Journal Title
Molecular Cell Biology
Volume: 35
Issue: 1
Pages: 211-223
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Endogenous Drp1 Mediates Mitochondrial Autophagy and Protects the Heart Agains Energy Stress.2015
Author(s)
Y. Ikeda, A. Shitakabe, Y. Maejeima, P. Zhai, S. Sciarretta, J. Toli, M. Nomura, K.Mihara, K. Egashira, M. Ohnishi, M. Abdellatif and J. Sadoshima
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Journal Title
Circulation Research
Volume: 116
Issue: 2
Pages: 264-278
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Mitochondrial Fission Factor Drp1 Maintains Oocyte Quality via Dynamic Rearrangement of Multiple Organelles2014
Author(s)
O Udagawa, T Ishihara, M Maeda, Y Matsunaga, S Tsukamoto, N Kawano, K Miyado, H Shitara, S Yokota, M Nomura, K Mihara, N Mizushima, N Ishihara
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Journal Title
Current Biology
Volume: 24
Issue: 20
Pages: 2451-2458
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fis1 acts as mitochondrial recruitment factor for TBC1D15 that involved in regulation of mitochondrial morphology2013
Author(s)
K. Onoue, A. Jofuku, R. Ban-Ishihara, T. Ishihara, M. Maeda, T. Koshiba, T. Itoh, M. Fukuda, H. Otera, T. Oka, H. Takano, N. Mizushima, K. Mihara and N. Ishihara
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Journal Title
J. Cell Sci.
Volume: 126
Pages: 176-185
Related Report
Peer Reviewed
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