Coordinated regulation of cell adhesion and growth through Rap1 signaling and mammalian Hippo pathway.
| Project/Area Number |
25291047
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Yoshihiro 関西医科大学, 医学部, 講師 (90533208)
KONDO Naoyuki 関西医科大学, 医学部, 助教 (30570840)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | Rap1 / Hippoシグナル / Mst1 / インテグリン / リンパ球 |
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| Outline of Final Research Achievements |
The Hippo pathway plays an important role in morphogenesis and cell proliferation. In this study, we investigated roles of the mammalian Hippo pathway in mice and humans, and revealed its novel roles in the immune system. The signal transduction through Rap1-RAPL -Mst1 /Mst2 (mammalian Hippo) were requisitely involved in the following processes; 1. thymic selections to eliminate self-reactive thymocytes, 2. antigen-specific adhesion of peripheral T cells to recognize foreign antigen, 3. antigen-specific suppressor functions of regulatory T cells, 4. the negative regulation of anti-tumor effects of cytotoxic T cells. These findings provide useful information to our understanding of inflammation, autoimmune, anti-tumor immunology and thereby development of therapeutics.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Integrin LFA-1 regulates cell adhesion via transient clutch formation2015
Author(s)
Ishibashi, M., Miyanaga, Y., Matsuoka, S., Kozuka, J., Togashi, Y., Kinashi, T. and Ueda, M.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 464
Issue: 2
Pages: 459-466
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hippo-Foxa2 signaling pathway plays a role in peripheral lung maturation and surfactant homeostasis.2013
Author(s)
Chung C, Kim T, Kim M, Kim M, Song H, Kim TS, Seo E, Lee SH, Kim H, Kim SK, Yoo G, Lee DH, Hwang DS, Kinashi T, Kim JM, Lim DS.
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Journal Title
Proc Natl Acad Sci U S A
Volume: 100:19
Issue: 19
Pages: 7732-37
DOI
Related Report
Peer Reviewed
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