| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2015: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|
|---|
| Outline of Final Research Achievements |
The Hippo pathway plays an important role in morphogenesis and cell proliferation. In this study, we investigated roles of the mammalian Hippo pathway in mice and humans, and revealed its novel roles in the immune system. The signal transduction through Rap1-RAPL -Mst1 /Mst2 (mammalian Hippo) were requisitely involved in the following processes; 1. thymic selections to eliminate self-reactive thymocytes, 2. antigen-specific adhesion of peripheral T cells to recognize foreign antigen, 3. antigen-specific suppressor functions of regulatory T cells, 4. the negative regulation of anti-tumor effects of cytotoxic T cells. These findings provide useful information to our understanding of inflammation, autoimmune, anti-tumor immunology and thereby development of therapeutics.
|
