Functional analysis of epigenetic intreating factors during heart regeneration
| Project/Area Number |
25291049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Takeuchi Jun 東京大学, 分子細胞生物学研究所, 准教授 (10451999)
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| Co-Investigator(Renkei-kenkyūsha) |
KOSHIBA KAZUKO 東京大学, 分子細胞生物学研究所, 講師 (30467005)
SHIRAHIGE KATSUHIKO 東京大学, 分子細胞生物学研究所, 教授 (90273854)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Keywords | 心臓再生 / エピジェネティック因子 / 運命決定 / 特定因子 / 細胞分化転換 / ChIP / 可塑性 / エピジェネティクス / ChIP-seq |
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| Outline of Final Research Achievements |
For mammalian heart regeneration or repair, we have reported about two factors during heart regeneration to JMCC (Morita et al., 2016a) and DGD (Nakamura et al., 2016). Sall1 which plays as a key factor for cardiac induction (Morita et al., JMCC 2016a) is also re-activated during heart regeneration (Morita et al., submitted 2016b). Baf60c has been identified as a key factor for cardiac formation (Koshiba-Takeuchi et al., Etiology and Morphogenesis of Congenital Heart Disease 2016; Takeuchi & Bruneau. Nature 2009) and also functions for heart regeneration (Nakamura et al., DGD 2016). These results will open the regenerative mechanisms in several organs for the basic science and will give us supportive idea for the heart repair in human.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Sall1 transiently marks undifferentiated heart precursors and regulates their fate.2016
Author(s)
Morita Y., Andersen P., Hotta A., Tsukahara Y., Sasagawa N., Hayashida N., Koga C., Nishikawa M., Saga Y., Evans SM., Koshiba-Takeuchi K., Nishinakamura R., Yoshida Y., Kwon C. and Takeuchi JK.
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Journal Title
Journal of Molecular and Cellular Cardiology
Volume: 92
Pages: 158-162
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.2015
Author(s)
Takeuchi, M., Higashino, A., Takeuchi, K., Hori, Y., Koshiba-Takeuchi, K., Makino, H., Monobe, Y., Kishida, M., Adachi, J., Takeuchi, J., Tomonaga, T., Umezawa, A., Kameoka, Y., and Akagi, K.
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Journal Title
PloS one
Volume: 10
Issue: 5
Pages: 0126562-0126562
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice.2014
Author(s)
Kondoh S, Inoue K, Igarashi K, Sugizaki H, Shirode-Fukuda Y, Inoue E, Yu T, Takeuchi JK, Kanno J, Bonewald LF, Imai Y.
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Journal Title
Bone
Volume: 60
Pages: 68-77
Related Report
Peer Reviewed
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[Presentation] 心臓をつくり護る因子2015
Author(s)
竹内純
Organizer
第32回国際心臓研究学会ISHRシンポジウム
Place of Presentation
神戸国際会議場（兵庫県神戸市）
Year and Date
2015-12-11
Related Report
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[Presentation] 心臓再生環境と心筋分化能力2015
Author(s)
竹内純
Organizer
第38回日本分子生物学会年会ワークショップ
Place of Presentation
神戸ポートアイランド（兵庫県神戸市）
Year and Date
2015-12-03
Related Report
Invited
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[Presentation] The Epigenetic Regulation for Cardiomyocyte Plasticity in Heart Regeneration2014
Author(s)
R Nakamura, K Takeuchi, T Sasano, Y Tsukahara, H Sadek, J Takeuchi, Y Hori, Y Ando, M Kojima, T Furukawa
Organizer
2014 Keystone Symposia Conference
Place of Presentation
Boston, USA
Year and Date
2014-04-08
Related Report
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[Presentation] Epigeneteic regulation promotes mammalian heart regeneration.2013
Author(s)
Ryo Nakamura, Kazuko Koshiba-Takeuchi, Yuko Tsukahara, Tetsuya Asano, Yutaro Hori, Yuki Ando, Mizuyo Kojima, Testushi Furukawa, Hesham A Sadek, Jun K Takeuchi
Organizer
ISHR( 国際心臓研究学会)
Place of Presentation
San Diego, USA
Year and Date
2013-06-29
Related Report
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