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Developmental mechanisms that specify digit identity and patterning

Research Project

Project/Area Number 25291050
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Developmental biology
Research InstitutionNagoya University

Principal Investigator

Suzuki Takayuki  名古屋大学, 理学(系)研究科(研究院), 講師 (40451629)

Co-Investigator(Renkei-kenkyūsha) MORISHITA Yoshihiro  理化学研究所QBiC, ユニットリーダー (00404062)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywordsパターン形成 / 軟骨 / ニワトリ / 形態形成 / 肢芽 / 手足 / ニワトリ胚 / fate map / 階層 / 3次元 / 指形成 / パターン / 発生 / 発生•分化 / 画像解析 / イメージング / 数理生物学 / モデル化 / 定量化 / 遺伝子
Outline of Final Research Achievements

Our skeletal pattern is derived from pattern of chondrocyte development. Therefore, studying first developmental step of chondrocyte should give us the most valuable information about positional information of skeletal pattern. In this study, we used chick hindlimb bud as a model system and performed how chondrocyte position is specified in the autopod. We succeeded to establish new quantification method to understand 3-dimentional structure of developing organ, especially limb bud in this study.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (16 results)

All 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Invited: 4 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Quantitative analysis of tissue deformation dynamics reveals threecharacteristic growth modes and globally aligned anisotropictissue deformation during chick limb developm2015

    • Author(s)
      Y. Morishita*, A. Kuroiwa, T. Suzuki*
    • Journal Title

      Development

      Volume: in press Pages: 1672-1683

    • DOI

      10.1242/dev.109728

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] AP-2β is a transcriptional regulator for determination of digit length in tetrapods.2015

    • Author(s)
      Seki R, Kitajima K, Matsubara H, Suzuki T, Saito D, Yokoyama H, Tamura K.
    • Journal Title

      Dev Biol.

      Volume: 407 Issue: 1 Pages: 75-89

    • DOI

      10.1016/j.ydbio.2015.08.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Efficient embryonic culture method for the Japanese striped snake, Elaphe quadrivirgata, and its early developmental stages2014

    • Author(s)
      Y. Matsubara, A. Sakai, A. Kuroiwa and T. Suzuki
    • Journal Title

      Dev Growth Differ

      Volume: 56 Issue: 8 Pages: 573-82

    • DOI

      10.1111/dgd.12157

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bayesian inference of whole-organ deformation dynamics from limited space-time point data2014

    • Author(s)
      Y. Morishita and T. Suzuki
    • Journal Title

      J Theor Biol

      Volume: 357 Pages: 74-85

    • DOI

      10.1016/j.jtbi.2014.04.027

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconstruction and in vivo analysis of the extinct tbx5 gene from ancient wingless moa (Aves: Dinornithiformes)2014

    • Author(s)
      Huynen L. et al.
    • Journal Title

      BMC Evolutionary Biology

      Volume: 14 Issue: 1 Pages: 75-82

    • DOI

      10.1186/1471-2148-14-75

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 脊椎動物における後肢の位置の多様性を生み出す分子メカニズム2015

    • Author(s)
      鈴木孝幸
    • Organizer
      第3回萌える生物学
    • Place of Presentation
      大阪大学
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 肢芽全体の形態形成の定量的解析方法と位置の多様性を生み出す分子メカニズム2015

    • Author(s)
      鈴木孝幸
    • Organizer
      第5回 Tokyo Vertebrate Morphology Meeting
    • Place of Presentation
      東京慈恵医科大学
    • Year and Date
      2015-08-12
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Quantification of special and temporal deformation dynamics to understand whole organ development2014

    • Author(s)
      Takayuki Suzuki
    • Organizer
      Biological time and biological space, NIBB
    • Place of Presentation
      NIBB
    • Year and Date
      2014-08-27
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Quantitative approach to understand whole organ morphogenesis2013

    • Author(s)
      Takayuki Suzuki
    • Organizer
      第46回日本発生生物学会大会
    • Place of Presentation
      くにびきメッセ
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Expression timing of Gdf11 reveals positional diversity of the hindlimb in vertebrates2013

    • Author(s)
      Takayuki Suzuki, Yoshiyuki Matsubara, Ayumi Hattori, Toshihiko Ogura, Se-Jin Lee, Atsushi Kuroiwa
    • Organizer
      17th International Congress of Developmental Biology
    • Place of Presentation
      Cancun, Mexico
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gdf11の発現開始タイミングの違いが脊椎動物における後肢の位置を決定する2013

    • Author(s)
      Takayuki Suzuki, Yoshiyuki Matsubara, Ayumi Hattori, Toshihiko Ogura, Se-Jin Lee, Atsushi Kuroiwa
    • Organizer
      数理生物学サマーレクチャーコース
    • Place of Presentation
      理化学研究所
    • Related Report
      2013 Annual Research Report
  • [Presentation] 劣性遺伝で多指症を発症するHMM変異体の発生学的解析

    • Author(s)
      鈴木孝幸、中野幹治、都築政起、松田洋一、黒岩厚
    • Organizer
      第1回ウズラ研究集会
    • Place of Presentation
      名古屋大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 器官全体の形態形成を明らかにするために必要な特徴量の提案と定量解析

    • Author(s)
      鈴木孝幸
    • Organizer
      新学術領域第3回若手の会
    • Place of Presentation
      ラフォーレ那須、栃木
    • Related Report
      2013 Annual Research Report
  • [Book] New principles in Developmental Process2014

    • Author(s)
      鈴木孝幸
    • Total Pages
      10
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Remarks] Developmental Morphogenesis

    • URL

      http://bunshi5-bio-nagoya-u.businesscatalyst.com/index.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] 名古屋大学形態発生学グループ

    • URL

      http://bunshi5-bio-nagoya-u.businesscatalyst.com/index.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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