| Budget Amount *help |
¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
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| Outline of Final Research Achievements |
Chloroplasts and mitochondria are the organelles that originate from endosymbiosis of respective ancestral bacteria and retain their own DNA as a remnant. Although these organelle DNAs are very limited as genetic content, they exist as multi-copy and vary in the amount. Moreover, tissue-specific degradation of organelle DNAs has been reported in literature since two decades ago but little is understood at the molecular level. Recently, our group identified DPD1 exonuclease, which is conserved in land plants, be dual targeted to plastids and mitochondria, and appear to degrade organelle DNA.
In this study, we attempted to corroborate the role of DPD1 in organelle DNA degradation. We focused on leaf senescence and examine the possibility that organelle DNA degradation is related to nutrient salvage.
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