Control of learning and memory by insulin in the molluscan brain
Project/Area Number |
25291074
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Partial Multi-year Fund |
Section | 一般 |
Research Field |
Animal physiology/Animal behavior
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Research Institution | Tokushima Bunri University |
Principal Investigator |
Ito Etsuro 徳島文理大学, 薬学部, 教授 (80203131)
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Co-Investigator(Kenkyū-buntansha) |
MATSUO Ryota 福岡女子大学, 国際文理学部, 准教授 (40334338)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
|
Keywords | モノアラガイ / 味覚嫌悪学習 / インスリン / 飢餓 / 満腹 / 長期記憶 / 学習 / 記憶 / グルコース / 学習記憶 |
Outline of Final Research Achievements |
The pond snail Lymnaea stagnalis is capable of learning taste aversion and consolidating this learning into long-term memory (LTM) that is called conditioned taste aversion (CTA). Previous studies showed that some molluscan insulin-related peptides (MIPs) were up-regulated in snails exhibiting CTA-LTM. In the present study, when we applied partially purified MIPs to the isolated CNS, we observed a long-term change in synaptic efficacy of the synaptic connection between the CTA-related neurons. Injection of insulin or insulin receptor antibody into the snail also suggested that MIPs trigger CTA-LTM. Finally, we could clarify the relation between the CTA grades and the nutritional states, such as food satiation or food starvation.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] What are the elements of motivation for acquisition of conditioned taste aversion?2014
Author(s)
K.Mita, A.Okuta, R.Okada, D.Hatakeyama, E.Otsuka, M.Yamagishi, M.Morikawa, Y.Naganuma, Y.Fujito, V.Dyakonova, K.Lukowiak and E.Ito
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Journal Title
Neurobiol. Learn. Mem.
Volume: 107
Pages: 1-12
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Involvement of insulin-like peptide in long-term synaptic plasticity and long-term memory of the pond snail Lymnaea stagnalis2013
Author(s)
Murakami J, Okada R, Sadamoto H, Kobayashi S, Mita K, Sakamoto Y, Yamagishi M, Hatakeyama D, Otsuka E, Okuta A, Sunada H, Takigami S, Sakakibara M, Fujito Y, Awaji M, Moriyama S, Lukowiak K, Ito E
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Journal Title
J Neurosc
Volume: 33
Issue: 1
Pages: 371-381
DOI
Related Report
Peer Reviewed
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