| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
The pond snail Lymnaea stagnalis is capable of learning taste aversion and consolidating this learning into long-term memory (LTM) that is called conditioned taste aversion (CTA). Previous studies showed that some molluscan insulin-related peptides (MIPs) were up-regulated in snails exhibiting CTA-LTM. In the present study, when we applied partially purified MIPs to the isolated CNS, we observed a long-term change in synaptic efficacy of the synaptic connection between the CTA-related neurons. Injection of insulin or insulin receptor antibody into the snail also suggested that MIPs trigger CTA-LTM. Finally, we could clarify the relation between the CTA grades and the nutritional states, such as food satiation or food starvation.
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