Research Project
Grant-in-Aid for Scientific Research (B)
We attempted to study the molecular mechanism for the maintenance of epigenetic gene regulation by SmcHD1, which was suggested to be independent of more general polycomb group proteins. SmcHD1 was initially assumed to be involved in the maintenance of the inactivated X chromosome. Knockout of both copies of Smchd1 in embryonic fibroblasts, which stably maintain the X-inactivated state, did not affected genes on the inactive X, suggesting that the X-inactivated state could be maintained in the absence of SmcHD1. SmcHD1 may rather play a role in the process of the establishment of X-inactivation by creating an appropriate chromatin environment required for the maintenance, and may be dispensable for the maintenance once such an environment was established.
All 2015 2014 2013
All Journal Article (7 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 7 results, Open Access: 5 results, Acknowledgement Compliant: 2 results) Presentation (37 results) (of which Invited: 6 results)
Development.
Volume: 142 Pages: 4299-4308
10.1242/dev.128819
Nature comm.
Volume: 6 Issue: 1 Pages: 8564-8564
10.1038/ncomms9564
Genes & Genetic Systems
Volume: 89 Issue: 4 Pages: 151-157
10.1266/ggs.89.151
130004750052
Cell
Volume: 159 Issue: 7 Pages: 1681-1697
10.1016/j.cell.2014.11.040
Cell Stem Cell
Volume: 14(2) Issue: 2 Pages: 217-227
10.1016/j.stem.2013.12.015
Chrom. Research
Volume: in press Issue: 3 Pages: 293-303
10.1007/s10577-014-9404-1
Reproduction
Volume: 146(4) Issue: 4 Pages: R131-R139
10.1530/rep-13-0173
