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The role of chromosome-retaining RNA transcripts in homologous chromosome recognition

Research Project

Project/Area Number 25291079
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Genetics/Chromosome dynamics
Research InstitutionNational Institute of Information and Communications Technology

Principal Investigator

DING DAQIAO  国立研究開発法人情報通信研究機構, 未来ICT研究所フロンティア創造総合研究室, 主任研究員 (50359080)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Keywords染色体 / 減数分裂 / 対合 / 非コードRNA / 分裂酵母
Outline of Final Research Achievements

Pairing of homologous chromosome is an essential step in meiosis that ensures effective homologous recombination and reductional segregation in meiotic division. In fission yeast, the formation of telomere bouquet and accompany telomere-led chromosome oscillation align the homologous chromosomes to the same direction and effectively promote their contact and pairing. However, the mechanisms for homologous chromosome specific recognition remain undefined. To understand the molecular mechanisms of meiRNA promoted pairing, we screened for sme2 locus-localization protein (smp). As a result, we found ten kinds of Smp and half of them are required for the robust pairing of the sme2 locus. These proteins are RNA binding proteins and/or involved in transcription termination. We propose that retaining of RNA transcripts on the chromosome play an important role in homologous chromosome recognition and pairing.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (24 results)

All 2016 2015 2014 2013 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (2 results) Remarks (4 results)

  • [Journal Article] A cohesion-based platform for homologous chromosome pairing in meiosis2016

    • Author(s)
      Da-Qiao Ding, Tokuko Haraguchi, Yasushi Hiraoka
    • Journal Title

      Current Genetics

      Volume: 印刷中 Issue: 3 Pages: 499-502

    • DOI

      10.1007/s00294-016-0570-x

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meiotic cohesion-based chromosome structure is essential for homologous chromosome pairing in Schizosaccharomyces pombe2015

    • Author(s)
      Ding DQ, Matsuda A, Okamasa K, Nagahama Y, Haraguchi T, Hiraoka Y
    • Journal Title

      Chromosoma

      Volume: special issue Issue: 2 Pages: 1-10

    • DOI

      10.1007/s00412-015-0551-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly condensed chromatins are formed adjacent to subtelomeric and decondensed silent chromatin in fission yeast.2015

    • Author(s)
      Matsuda A, Chikashige Y, Ding DQ, Ohtsuki C, Mori C, Asakawa H, Kimura H, Haraguchi T, Hiraoka Y.
    • Journal Title

      Nature Communication

      Volume: 6 Issue: 1 Pages: 1-12

    • DOI

      10.1038/ncomms8753

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The role of chromosomal retention of noncoding RNA in meiosis2013

    • Author(s)
      Ding DQ, Haraguchi T, Hiraoka Y.
    • Journal Title

      Chromosome Res.

      Volume: 21 Issue: 6-7 Pages: 665-672

    • DOI

      10.1007/s10577-013-9389-1

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 減数分裂期前期相同染色体対合に寄与する因子の特定と解析2016

    • Author(s)
      丁 大橋、岡正華澄、長濱有紀、原口徳子、平岡 泰
    • Organizer
      酵母遺伝学フォーラム第49回研究報告会
    • Place of Presentation
      シーサイドホテル舞子ビラ、神戸市垂水区、兵庫県
    • Related Report
      2016 Annual Research Report
  • [Presentation] 減数分裂期前期相同染色体対合に寄与する ncRNA及び制御因子の特定と解析2016

    • Author(s)
      丁 大橋、岡正華澄、長濱有紀、原口徳子、平岡 泰
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜市西区、神奈川県
    • Related Report
      2016 Annual Research Report
  • [Presentation] 3D-SIM Analysis of Meiotic Chromosome Structure in Live Cells of S. pombe2015

    • Author(s)
      丁大橋
    • Organizer
      EMBO Conference on Meiosis
    • Place of Presentation
      University of Oxford, Oxford, UK
    • Year and Date
      2015-09-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 相同染色体認識における 非コードDNAの役割2015

    • Author(s)
      丁大橋
    • Organizer
      第9回 非コードDNA班会議 & 第2回 国際シンポジウム
    • Place of Presentation
      兵庫県淡路市夢舞台 淡路夢舞台国際会議場
    • Year and Date
      2015-08-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 3D-SIM Analysis of Meiotic Chromosome Structure in Live Cells of S.pombe2015

    • Author(s)
      丁大橋
    • Organizer
      Pombe 2015 8TH INTERNATIONAL FISSION YEAST MEETING
    • Place of Presentation
      兵庫県神戸市中央区 生田神社会館
    • Year and Date
      2015-06-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A role for chromosomal RNA bodies in fission yeast meiosis2014

    • Author(s)
      平岡 泰
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市みなとみらい
    • Year and Date
      2014-11-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分裂酵母減数分裂期前期染色体構造の解析2014

    • Author(s)
      丁 大橋
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      神奈川県横浜市みなとみらい
    • Year and Date
      2014-11-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 相同染色体対合における非コードDNAの役割2014

    • Author(s)
      丁 大橋
    • Organizer
      新学術領域研究 「ゲノムを支える非コードDNA領域の機能」 2014年第7回領域会議
    • Place of Presentation
      神奈川県湯河原温泉ホテルあかね
    • Year and Date
      2014-07-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Fine structures of meiosis-specific chromosome and homologous chromosome pairing in S. pombe2014

    • Author(s)
      丁 大橋
    • Organizer
      Gordon Research Conferences Meiosis
    • Place of Presentation
      Colby-Saweyer College, New London, NH, USA
    • Year and Date
      2014-06-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 分裂酵母減数分裂期前期染色体構造の3D-SIM解析2014

    • Author(s)
      丁 大橋
    • Organizer
      「ゲノムを支える非コードDNA領域の機能」公開シンポジウム インターメアによる染色体制御機構
    • Place of Presentation
      東京大学山上会館、東京都文京区
    • Related Report
      2013 Annual Research Report
  • [Presentation] 相同染色体認識における 非コードDNAの役割2013

    • Author(s)
      丁 大橋
    • Organizer
      「ゲノムを支える非コードDNA 領域の機能」 第5回領域会議
    • Place of Presentation
      湘南国際村、神奈川県三浦郡葉山町
    • Related Report
      2013 Annual Research Report
  • [Presentation] 分裂酵母減数分裂期前期染色体構造の3D-SIM解析2013

    • Author(s)
      丁 大橋
    • Organizer
      第31回染色体ワークショップ・第12回核ダイナミクス研究会
    • Place of Presentation
      ホテルおかだ、神奈川県足柄下郡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Fine structures of meiosis-specific chromosome and homologous chromosome pairing in S. pombe2013

    • Author(s)
      丁 大橋
    • Organizer
      Pombe 2013 (7th International Fission Yeast Meeting)
    • Place of Presentation
      University of London, UK
    • Related Report
      2013 Annual Research Report
  • [Presentation] Live and 3D structured illumination microscopy revealed dynamic and highly organized meiotic specific chromosome architectures in fission yeast2013

    • Author(s)
      丁 大橋
    • Organizer
      The 4th Xiamen Winter Symposium
    • Place of Presentation
      Xiamen University,Xiamen,China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Visualization of a Specific Genome Locus by the lacO/Lacl-GFP System. In Fission Yeast: A Laboratory Manual2016

    • Author(s)
      Ding DQ, Hiraoka Y
    • Total Pages
      6
    • Publisher
      Cold Spring Harbor Laboratory Press
    • Related Report
      2016 Annual Research Report
  • [Book] Microscopic Observation of Living Cells Stained with Fluorescent Probes. In Fission Yeast: A Laboratory Manual2016

    • Author(s)
      Asakawa H, Ding DQ, Haraguchi T, Hiraoka Y
    • Total Pages
      6
    • Publisher
      Cold Spring Harbor Laboratory Press
    • Related Report
      2016 Annual Research Report
  • [Remarks] Cell Magic

    • URL

      http://www2.nict.go.jp/frontier/seibutsu/CellMagic/index.html

    • Related Report
      2016 Annual Research Report
  • [Remarks] Cell Magic

    • URL

      http://www2.nict.go.jp/advanced_ict/bio/w131103/CellMagic/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] Cell Magic

    • URL

      http://www2.nict.go.jp/advanced_ict/bio/w131103/CellMagic/

    • Related Report
      2014 Annual Research Report
  • [Remarks] CellMagic

    • URL

      http://www2.nict.go.jp/advanced_ict/bio/w131103/CellMagic/

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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