The role of chromosome-retaining RNA transcripts in homologous chromosome recognition
| Project/Area Number |
25291079
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genetics/Chromosome dynamics
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| Research Institution | National Institute of Information and Communications Technology |
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Principal Investigator |
DING DAQIAO 国立研究開発法人情報通信研究機構, 未来ICT研究所フロンティア創造総合研究室, 主任研究員 (50359080)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2014: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
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| Keywords | 染色体 / 減数分裂 / 対合 / 非コードRNA / 分裂酵母 |
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| Outline of Final Research Achievements |
Pairing of homologous chromosome is an essential step in meiosis that ensures effective homologous recombination and reductional segregation in meiotic division. In fission yeast, the formation of telomere bouquet and accompany telomere-led chromosome oscillation align the homologous chromosomes to the same direction and effectively promote their contact and pairing. However, the mechanisms for homologous chromosome specific recognition remain undefined. To understand the molecular mechanisms of meiRNA promoted pairing, we screened for sme2 locus-localization protein (smp). As a result, we found ten kinds of Smp and half of them are required for the robust pairing of the sme2 locus. These proteins are RNA binding proteins and/or involved in transcription termination. We propose that retaining of RNA transcripts on the chromosome play an important role in homologous chromosome recognition and pairing.
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Report
(5 results)
Research Products
(24 results)
