| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
We examined the possibility that diverse epigenomes as opposed to diverse genomes might serve as units of adaptive evolution. We used Helicobacter pylori. We knocked out several genes determining sequence specificity of DNA methylation and analyzed their effects on transcriptome. Based on these, we examined adaptation-related phenotype sets and found unique effects. From 30 H. pylori genome comparison, we revealed high diversity in the restriction-modification systems. It did not closely match the population structure based on genome sequences. We looked for codons with diversifying selection, and found some in the specificity subunits of the restriction-modification systems.
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