| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
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| Outline of Final Research Achievements |
In order to elucidate the origin of the asymmetry of life on Earth (nucleic acids are composed of D-sugars, whereas proteins are composed of L-amino acids), I focused on the process of tRNA aminoacylation that is the first encounter step between RNAs and amino acids. The model molecule synthesis based on “chiral-selective aminoacylation of RNA”, which I discovered in 2004, for the purpose of performing X-ray crystallography was successful. In addition, comparison of the energies of the final products of the reaction was done by using molecular dynamics. I also found the change of the viscosity of nucleotide solution containing cyanuric acid.
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