RNA and Amino Acid: Elucidation of the Mystery of the Asymmetry of Life
| Project/Area Number |
25291082
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Evolutionary biology
|
|---|
| Research Institution | Tokyo University of Science |
|---|
Principal Investigator |
TAMURA Koji 東京理科大学, 基礎工学部, 教授 (30271547)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
|
|---|
| Keywords | RNA / アミノ酸 / ホモキラリティー / 起源 / 非対称性 / 生命起源 |
|---|
| Outline of Final Research Achievements |
In order to elucidate the origin of the asymmetry of life on Earth (nucleic acids are composed of D-sugars, whereas proteins are composed of L-amino acids), I focused on the process of tRNA aminoacylation that is the first encounter step between RNAs and amino acids. The model molecule synthesis based on “chiral-selective aminoacylation of RNA”, which I discovered in 2004, for the purpose of performing X-ray crystallography was successful. In addition, comparison of the energies of the final products of the reaction was done by using molecular dynamics. I also found the change of the viscosity of nucleotide solution containing cyanuric acid.
|
Report
(4 results)
Research Products
(49 results)
-
-
-
-
-
-
[Journal Article] Glycols modulate terminator stem stability and ligand-dependency of a glycine riboswitch2013
Author(s)
Hamachi, K., Hayashi, H., Shimamura, M., Yamaji, Y., Kaneko, A., Fujisawa, A., Umehara, T. and Tamura, K
-
Journal Title
BioSystems
Volume: 113
Issue: 2
Pages: 59-65
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
